A report on Methamphetamine

Desoxyn (Methamphetamine Hydrochloride) 100 tablets.
A 2010 study ranking various illegal and legal drugs based on statements by drug-harm experts. Methamphetamine was found to be the fourth most damaging to society.
A suspected case of meth mouth
This diagram depicts the neuroimmune mechanisms that mediate methamphetamine-induced neurodegeneration in the human brain. The NF-κB-mediated neuroimmune response to methamphetamine use which results in the increased permeability of the blood–brain barrier arises through its binding at and activation of sigma receptors, the increased production of reactive oxygen species (ROS), reactive nitrogen species (RNS), and damage-associated molecular pattern molecules (DAMPs), the dysregulation of glutamate transporters (specifically, EAAT1 and EAAT2) and glucose metabolism, and excessive Ca2+ ion influx in glial cells and dopamine neurons.
This illustration depicts the normal operation of the dopaminergic terminal to the left, and the dopaminergic terminal in the presence of methamphetamine to the right. Methamphetamine reverses the action of the dopamine transporter (DAT) by activating TAAR1 (not shown). TAAR1 activation also causes some of the dopamine transporters to move into the presynaptic neuron and cease transport (not shown). At VMAT2 (labeled VMAT), methamphetamine causes dopamine efflux (release).
Shards of pure methamphetamine hydrochloride, also known as crystal meth
Pervitin, a methamphetamine brand used by German soldiers during World War II, was dispensed in these tablet containers.
U.S. drug overdose related fatalities in 2017 were 70,200, including 10,333 of those related to psychostimulants (including methamphetamine).

Potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity.

- Methamphetamine

66 related topics with Alpha

Overall

Amphetamine

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Strong central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity.

Strong central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity.

It is also the parent compound of its own structural class, the substituted amphetamines, which includes prominent substances such as bupropion, cathinone, MDMA, and methamphetamine.

Ritalin: 20 mg sustained-release (SR) tablets

Stimulant

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Overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects.

Overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects.

Ritalin: 20 mg sustained-release (SR) tablets
A chart comparing the chemical structures of different amphetamine derivatives
Roasted coffee beans, a common source of caffeine.
Tablets containing MDMA
Lines of illicit cocaine, used as a recreational stimulant
Catha edulis

For the category "amphetamines and prescription stimulants" (with "amphetamines" including amphetamine and methamphetamine) the value was 0.7%, and for MDMA 0.4%.

Adriaen Brouwer, TheSmokers (1636)

Recreational drug use

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Altered state of consciousness either for pleasure or for some other casual purpose or pastime by modifying the perceptions, feelings, and emotions of the user.

Altered state of consciousness either for pleasure or for some other casual purpose or pastime by modifying the perceptions, feelings, and emotions of the user.

Adriaen Brouwer, TheSmokers (1636)
Edgar Degas, L'Absinthe (1876)
Bhang eaters from India c. 1790. Bhang is an edible preparation of cannabis native to the Indian subcontinent. It has been used in food and drink as early as 1000 BCE by Hindus in ancient India.
A man smoking cannabis in Kolkata, India
A rational harm assessment of drugs<ref>{{Cite journal|last1=Blakemore|first1=Colin|last2=Saulsbury|first2=William|last3=King|first3=Leslie A.|last4=Nutt|first4=David|date=2007-03-24|title=Development of a rational scale to assess the harm of drugs of potential misuse|url=https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)60464-4/abstract|journal=The Lancet|language=en|volume=369|issue=9566|pages=1047–1053|doi=10.1016/S0140-6736(07)60464-4|issn=0140-6736|pmid=17382831|s2cid=5903121}}</ref>
This 1914 photo shows intoxicated men at a sobering-up room
alt=A chart showing dependence potential versus safety ratio.|An analysis of the dangers of drugs<ref>{{Cite book|url=https://books.google.com/books?id=xpZhjBuDkuwC&pg=PA149|title=Drugs and Society: U.S. Public Policy|last=Fish|first=Jefferson M.|date=2006|publisher=Rowman & Littlefield|isbn=9780742542457|language=en}}</ref>
Total recorded alcohol per capita consumption (15+), in liters of pure alcohol
Caffeinated alcoholic beverages, such as Vodka Red Bull, are widespread and legal routes of administration for multiple drugs.
Insufflation of powdered drug
Injection of heroin
Cocaine is a commonly used stimulant
alt=A chart showing relative drug harm.|A chart showing relative drug harm.

What controlled substances are considered generally unlawful to possess varies by country, but usually includes methamphetamine, heroin, cocaine, LSD, psilocybin mushrooms, MDMA, Lean, and club drugs.

Racemic amphetamine skeleton

Substituted amphetamine

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Substituted amphetamines are a class of compounds based upon the amphetamine structure; it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with substituents.

Substituted amphetamines are a class of compounds based upon the amphetamine structure; it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with substituents.

Racemic amphetamine skeleton
This shows phenethylamine in blue with its substitution points marked. Amphetamine and its substituted derivatives contain a CH3 group at the alpha-position (Rα).
This shows amphetamine with its substitution points marked, excluding the N-position at the NH2 group which is unmarked.
Amphetamine pills

Examples of substituted amphetamines are amphetamine (itself), methamphetamine, ephedrine, cathinone, phentermine, mephentermine, bupropion, methoxyphenamine, selegiline, amfepramone (diethylpropion), pyrovalerone, MDMA (ecstasy), and DOM (STP).

U.S. Food and Drug Administration agents inspect packages for illegal drug shipments at an international mail facility in New York

Controlled Substances Act

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Statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated.

Statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated.

U.S. Food and Drug Administration agents inspect packages for illegal drug shipments at an international mail facility in New York

7) The 1993 Domestic Chemical Diversion and Control Act (effective on April 16, 1994) in response to methamphetamine trafficking.

Ambergris

Aphrodisiac

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Substance that increases sexual desire, sexual attraction, sexual pleasure, or sexual behavior.

Substance that increases sexual desire, sexual attraction, sexual pleasure, or sexual behavior.

Ambergris
Yohimbine chemical structure
Alcohol Molecule
Ginseng
MDMA Molecule, the compound found in "Ecstacy"
An advertisement for pills from 1926 implies an aphrodisiac effect: "full of red-blooded vim and push".

Unnatural aphrodisiacs like ecstasy or methamphetamine are classified as those that are manufactured to imitate a natural substance.

MDMA (Ecstasy) pills. The Convention allows only government-approved medical and scientific uses of this and other substances.

Convention on Psychotropic Substances

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United Nations treaty designed to control psychoactive drugs such as amphetamine-type stimulants, barbiturates, benzodiazepines, and psychedelics signed in Vienna, Austria on 21 February 1971.

United Nations treaty designed to control psychoactive drugs such as amphetamine-type stimulants, barbiturates, benzodiazepines, and psychedelics signed in Vienna, Austria on 21 February 1971.

MDMA (Ecstasy) pills. The Convention allows only government-approved medical and scientific uses of this and other substances.
Despite its well-known presence in the rave scene, ketamine remains uncontrolled internationally due to its importance as an anesthetic in veterinary medicine.
Article 32 makes an exception for peyote and other wild psychotropic plants, to protect use in religious rituals in case such plants themselves were in the future added to Schedule I.
Psilocybin mushrooms are not controlled by the Convention, but the drugs contained in them are.
LSD and equipment used in its manufacture are subject to seizure under Article 22.
Crystal meth has emerged as a commonly abused drug, from the American and European rave scenes to East Asia.

However, the Commission on Narcotics Drugs and the International Narcotics Control Board listed the drug as a Table I precursor under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances because ephedrine can be used as chemical precursor for synthetize or manufacture amphetamine or methamphetamine, both which are actually controlled substances, a move that did not require WHO approval.

Levomethamphetamine

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Levomethamphetamine is the levorotatory (L-enantiomer) form of methamphetamine.

Stimulant psychosis

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Mental disorder characterized by psychotic symptoms which involves and typically occurs following an overdose or several day 'binge' on psychostimulants; however, it has also been reported to occur in approximately 0.1% of individuals, within the first several weeks after starting amphetamine or methylphenidate therapy.

Mental disorder characterized by psychotic symptoms which involves and typically occurs following an overdose or several day 'binge' on psychostimulants; however, it has also been reported to occur in approximately 0.1% of individuals, within the first several weeks after starting amphetamine or methylphenidate therapy.

Commonly abused amphetamines include methamphetamine, MDMA, 4-FA, as well as substituted cathinones like a-PVP, MDPV, and mephedrone, though a large number of other closely related compounds have been recently synthesized.

Playing can induce an intense state of happiness and contentment, like this young girl playing in the snow.

Euphoria

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Experience of pleasure or excitement and intense feelings of well-being and happiness.

Experience of pleasure or excitement and intense feelings of well-being and happiness.

Playing can induce an intense state of happiness and contentment, like this young girl playing in the snow.
A large dose of methamphetamine causes a drug-induced euphoria.

Dopaminergic stimulants like amphetamine, methamphetamine, cocaine, MDMA, and methylphenidate are euphoriants.