Methaqualone

QuaaludesQuaaludeMandraxQualudes714LudesmandiesMandrexmessed up on some kind of pillsMozambin
Methaqualone was a sedative and hypnotic medication, formerly sold under the brand name Quaalude and Mandrax until commercial production was halted.wikipedia
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Club drug

club drugsparty drugsdrug use
Methaqualone became increasingly popular as a recreational drug and club drug in the late 1960s and 1970s, known variously as "ludes" or "sopers" (also "soaps") in the United States and "mandrakes" and "mandies" in the United Kingdom, Australia and New Zealand.
Club drugs range from entactogens such as MDMA ("ecstasy"), 2C-B ("nexus") and inhalants (e.g., nitrous oxide and poppers) to stimulants (e.g., amphetamine and cocaine), depressants/sedatives (Quaaludes, GHB, Rohypnol) and psychedelic and hallucinogenic drugs (LSD, magic mushrooms and DMT).

Date rape drug

date rape drugsdate-rape drugdrug
It is also a common date rape drug.
Other drugs that have been used include hypnotics such as zopiclone, methaqualone and the widely available zolpidem (Ambien), sedatives such as neuroleptics (anti-psychotics), chloral hydrate and some histamine H1 antagonists, common recreational drugs such as ethanol, cocaine, and less common anticholinergics, barbiturates, opioids, PCP, scopolamine, nasal spray ingredient oxymetazoline, and certain solvents like GHB, GBL, and BD.

Muscle relaxant

skeletal muscle relaxantmuscle relaxantsmuscle relaxation
Its use peaked in the early 1970s for the treatment of insomnia, and as a sedative and muscle relaxant.
Other skeletal muscle relaxants of that type used around the world come from a number of drug categories and other drugs used primarily for this indication include orphenadrine (anticholinergic), chlorzoxazone, tizanidine (clonidine relative), diazepam, tetrazepam and other benzodiazepines, mephenoxalone, methocarbamol, dantrolene, baclofen, Drugs once but no longer or very rarely used to relax skeletal muscles include meprobamate, barbiturates, methaqualone, glutethimide and the like; some subcategories of opioids have muscle relaxant properties, and some are marketed in combination drugs with skeletal and/or smooth muscle relaxants such as whole opium products, some ketobemidone, piritramide and fentanyl preparations and Equagesic.

Hypnotic

sleeping pillssleeping pillsoporific
Methaqualone was a sedative and hypnotic medication, formerly sold under the brand name Quaalude and Mandrax until commercial production was halted.
Examples of quinazolinones include cloroqualone, diproqualone, etaqualone (Aolan, Athinazone, Ethinazone), mebroqualone, mecloqualone (Nubarene, Casfen), and methaqualone (Quaalude).

Recreational drug use

recreational drugdrug userecreational drugs
Methaqualone became increasingly popular as a recreational drug and club drug in the late 1960s and 1970s, known variously as "ludes" or "sopers" (also "soaps") in the United States and "mandrakes" and "mandies" in the United Kingdom, Australia and New Zealand.

Quinazolinone

quinazolone
It is a member of the quinazolinone class.

Drug overdose

overdoseoverdosingoverdosed
An overdose can lead to nervous system shutdown, coma and death.

Mecloqualone

The DEA has also added the methaqualone analogue mecloqualone (also a result of some incomplete clandestine syntheses) to Schedule I as ACSCN 2572, with zero manufacturing quota.
Mecloqualone (Nubarene, Casfen) is a Quinazolinone-class GABAergic and is an analogue of methaqualone that was first made in 1960 and marketed mainly in France and some other European countries.

Bill Cosby sexual assault cases

sexual assault allegationssexual assault accusationsallegations of sexual assault against him
In his testimony, Cosby admitted to casual sex involving recreational use of the sedative-hypnotic methaqualone (Quaaludes) with a series of young women, and he acknowledged that his dispensing the prescription drug was illegal.

Controlled Drugs and Substances Act

Schedule IVSchedule ISchedule 1
In Canada, methaqualone is listed in Schedule III of the Controlled Drugs and Substances Act and requires a prescription, but it is no longer manufactured.

Syed Husain Zaheer

Methaqualone was first synthesized in India in 1951 by Indra Kishore Kacker and Syed Husain Zaheer, for use as an antimalarial medication.
In 1951, along with Indra Kishore Kacker, he was the first to synthesize Methaqualone.

Sedative

sedativessedative-hypnoticsedated
Methaqualone was a sedative and hypnotic medication, formerly sold under the brand name Quaalude and Mandrax until commercial production was halted.

Insomnia

trouble sleepingsleeplessnessdifficulty sleeping
Its use peaked in the early 1970s for the treatment of insomnia, and as a sedative and muscle relaxant.

Free base

freebasingfree-basefreebase
The substance was sold both as a free base and as salt (hydrochloride).

GABA receptor

GABAGABA receptorsGABA A receptors
Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system, similarly to benzodiazepines and barbiturates.

Benzodiazepine

benzodiazepinesbenzodiazapinesbenzo
Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system, similarly to benzodiazepines and barbiturates.

Barbiturate

barbituratesbarbiturate withdrawalsleeping pill
Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system, similarly to benzodiazepines and barbiturates.

Pregnancy category

pregnancy category Cpregnancy category Dpregnancy categories
Methaqualone was not recommended for use while pregnant and is in pregnancy category D.

Coma

comatoseunresponsivecomatose state
An overdose can lead to nervous system shutdown, coma and death.

Death

mortalitydeceaseddead
An overdose can lead to nervous system shutdown, coma and death.

Delirium

deliriousconfusionAcute confusional state
Additional effects are delirium, convulsions, hypertonia, hyperreflexia, vomiting, kidney failure, coma, and death through cardiac or respiratory arrest.

Convulsion

convulsionsconvulsiveconvulsing
Additional effects are delirium, convulsions, hypertonia, hyperreflexia, vomiting, kidney failure, coma, and death through cardiac or respiratory arrest.

Hypertonia

muscle rigidityhypertonicmuscle hypertonia
Additional effects are delirium, convulsions, hypertonia, hyperreflexia, vomiting, kidney failure, coma, and death through cardiac or respiratory arrest.

Hyperreflexia

Hyperactive reflexesoverresponsive reflexesAbnormally fast reflexes
Additional effects are delirium, convulsions, hypertonia, hyperreflexia, vomiting, kidney failure, coma, and death through cardiac or respiratory arrest.