Methotrexate

amethopterin(M)'''ethotrexateFolexmethotrexatmethotrexate toxicityTrexall
Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant.wikipedia
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Psoriasis

plaque psoriasispsoriasis vulgarispsoriatic
Types of autoimmune diseases it is used for include psoriasis, rheumatoid arthritis, and Crohn's disease. It is used as a disease-modifying treatment for some autoimmune diseases, including rheumatoid arthritis, juvenile dermatomyositis, psoriasis, psoriatic arthritis, lupus, sarcoidosis, Crohn's disease, eczema and many forms of vasculitis.
These treatments include steroid creams, vitamin D3 cream, ultraviolet light and immune system suppressing medications, such as methotrexate.

Rheumatoid arthritis

rheumatoidRArheumatic arthritis
Types of autoimmune diseases it is used for include psoriasis, rheumatoid arthritis, and Crohn's disease.
Disease-modifying antirheumatic drugs (DMARDs), such as hydroxychloroquine and methotrexate, may be used to try to slow the progression of disease.

Crohn's disease

Crohn’s diseasechronCrohn
Types of autoimmune diseases it is used for include psoriasis, rheumatoid arthritis, and Crohn's disease.
In those newly diagnosed, a corticosteroid may be used for a brief period of time to rapidly improve symptoms alongside another medication such as either methotrexate or a thiopurine used to prevent recurrence.

Ectopic pregnancy

ectopic pregnanciesectopictubal pregnancy
It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions.
The use of the medication methotrexate works as well as surgery in some cases.

Chemotherapy

chemotherapeuticantineoplasticantineoplastic agent
Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant.
Simple blood tests are also available for dose optimization of methotrexate, 5-FU, paclitaxel, and docetaxel.

Sarcoidosis

pulmonary sarcoidosissarcoidBoeck's Sarcoidosis
It is used as a disease-modifying treatment for some autoimmune diseases, including rheumatoid arthritis, juvenile dermatomyositis, psoriasis, psoriatic arthritis, lupus, sarcoidosis, Crohn's disease, eczema and many forms of vasculitis.
Medications such as methotrexate, chloroquine, or azathioprine may occasionally be used in an effort to decrease the side effects of steroids.

Systemic lupus erythematosus

lupusSLEsystemic lupus
It is used as a disease-modifying treatment for some autoimmune diseases, including rheumatoid arthritis, juvenile dermatomyositis, psoriasis, psoriatic arthritis, lupus, sarcoidosis, Crohn's disease, eczema and many forms of vasculitis.
Treatments may include NSAIDs, corticosteroids, immunosuppressants, hydroxychloroquine, and methotrexate.

Abortion

abortionsabortaborted
It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions.
The most common early first-trimester medical abortion regimens use mifepristone in combination with a prostaglandin analog (misoprostol or gemeprost) up to 9 weeks gestational age, methotrexate in combination with a prostaglandin analog up to 7 weeks gestation, or a prostaglandin analog alone.

Misoprostol

misoprostol)prior induced abortion
Methotrexate is an abortifacient and is commonly used to terminate pregnancies during the early stages, generally in combination with misoprostol.
For abortions it is often used with mifepristone or methotrexate.

Folate

folic acidfolate biosynthesisone carbon pool by folate
It acts by blocking the body's use of folic acid. In 1947, a team of researchers led by Sidney Farber showed aminopterin, a chemical analogue of folic acid developed by Yellapragada Subbarao of Lederle, could induce remission in children with acute lymphoblastic leukemia.
The antifolate drug methotrexate is often used to treat cancer because it inhibits the production of the active form of THF from the inactive dihydrofolate (DHF).

Abortifacient

abortifacients8-month-after pillabortifacent
Methotrexate is an abortifacient and is commonly used to terminate pregnancies during the early stages, generally in combination with misoprostol.
Prostaglandin analogues, such as misoprostol or gemeprost (both synthetic prostaglandin E 1 (PGE 1 ) analogues), are often used to terminate pregnancy up to 24 or 60 days of gestation, in combination with mifepristone (a progesterone receptor antagonist) or methotrexate (an antifolate).

Intramuscular injection

intramuscularinjection into a muscleinjection into muscle
Methotrexate can be given by mouth or by injection (intramuscular, intravenous, subcutaneous, or intrathecal).
Methotrexate

Antifolate

folate antimetabolitefolic acid antagonistanti folate
Methotrexate is an antimetabolite of the antifolate type.

Breast cancer

breastbreast carcinomacancer
Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, and osteosarcoma.
Another common treatment is cyclophosphamide, methotrexate, and fluorouracil (or "CMF").

WHO Model List of Essential Medicines

World Health Organization's List of Essential MedicinesList of Essential MedicinesModel List of Essential Medicines
It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.
Methotrexateα

Osteosarcoma

osteogenic sarcomabone cancerosteosarcomas
Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, and osteosarcoma.
Standard therapy is a combination of limb-salvage orthopedic surgery when possible (or amputation in some cases) and a combination of high-dose methotrexate with leucovorin rescue, intra-arterial cisplatin, adriamycin, ifosfamide with mesna, BCD (bleomycin, cyclophosphamide, dactinomycin), etoposide, and muramyl tripeptide.

Yellapragada Subbarow

Y. Subba RowYellapragada Subba Rao
In 1947, a team of researchers led by Sidney Farber showed aminopterin, a chemical analogue of folic acid developed by Yellapragada Subbarao of Lederle, could induce remission in children with acute lymphoblastic leukemia.
Yellapragada Subbarao (12 January 1895 – 8 August 1948) was an pioneering Indian biochemist who discovered the function of adenosine triphosphate as an energy source in the cell, developed methotrexate for the treatment of cancer and discovered a broad spectrum of antibiotics including Auromycin and Tetracycline.

Tetrahydrofolic acid

tetrahydrofolate5,6,7,8-tetrahydrofolatetetrahydrofolates
For cancer, methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis.
This reaction is inhibited by methotrexate.

Leukemia

leukaemialeukemiasleukemic
Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, and osteosarcoma.
Consolidation therapy or intensification therapy to eliminate any remaining leukemia cells. There are many different approaches to consolidation, but it is typically a high-dose, multi-drug treatment that is undertaken for a few months. People with low- to average-risk ALL receive therapy with antimetabolite drugs such as methotrexate and 6-mercaptopurine (6-MP). People who are high-risk receive higher drug doses of these drugs, plus additional drugs.

Jane C. Wright

Jane Cooke WrightWright, Jane C.
In 1951, Jane C. Wright demonstrated the use of methotrexate in solid tumors, showing remission in breast cancer.
She also pioneered the use of the drug methotrexate to treat breast cancer and skin cancer (mycosis fungoids).

Aspirin

acetylsalicylic acidASAbaby aspirin
Use of low doses of methotrexate together with NSAIDS such as aspirin or analgesics such as paracetamol is relatively safe in people being treated for rheumatoid arthritis, if adequate monitoring is done.
Aspirin is known to displace a number of drugs from protein-binding sites in the blood, including the antidiabetic drugs tolbutamide and chlorpropamide, warfarin, methotrexate, phenytoin, probenecid, valproic acid (as well as interfering with beta oxidation, an important part of valproate metabolism), and other NSAIDs.

Pulmonary fibrosis

lung fibrosisfibrosislung scarring
The most common adverse effects include: hepatotoxicity (liver damage), ulcerative stomatitis, leukopenia and thus predisposition to infection, nausea, abdominal pain, fatigue, fever, dizziness, acute pneumonitis, rarely pulmonary fibrosis, and kidney failure.
Certain medications, e.g. amiodarone, bleomycin (pingyangmycin), busulfan, methotrexate, apomorphine, and nitrofurantoin

Psoriatic arthritis

psoriatic arthropathyarthritis, psoriaticpsoriasis arthritis
It is used as a disease-modifying treatment for some autoimmune diseases, including rheumatoid arthritis, juvenile dermatomyositis, psoriasis, psoriatic arthritis, lupus, sarcoidosis, Crohn's disease, eczema and many forms of vasculitis.
Drugs such as methotrexate or leflunomide are commonly prescribed; other DMARDS used to treat psoriatic arthritis include cyclosporin, azathioprine, and sulfasalazine.

TNF inhibitor

anti-TNFinhibits TNF-alphaTNF blockers
Recently, use of methotrexate in combination with anti-TNF agents has been shown to be effective for the treatment of ulcerative colitis.
Therapy which combines certain anti-TNF agents such as etanercept with DMARDs such as methotrexate has been shown to be more effective at restoring quality of life to sufferers of rheumatoid arthritis than using either drug alone.

Disease-modifying antirheumatic drug

antirheumaticdisease-modifying antirheumatic drugsanti-rheumatic
It is used as a disease-modifying treatment for some autoimmune diseases, including rheumatoid arthritis, juvenile dermatomyositis, psoriasis, psoriatic arthritis, lupus, sarcoidosis, Crohn's disease, eczema and many forms of vasculitis.