Minor physical anomalies

Minor physical anomalies (MPAs) are relatively minor (typically painless and, in themselves, harmless) congenital physical abnormalities consisting of features such as low-set ears, single transverse palmar crease, telecanthus, micrognathism, macrocephaly, hypotonia and furrowed tongue.wikipedia
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Birth defect

congenitalcongenital disorderbirth defects
Minor physical anomalies (MPAs) are relatively minor (typically painless and, in themselves, harmless) congenital physical abnormalities consisting of features such as low-set ears, single transverse palmar crease, telecanthus, micrognathism, macrocephaly, hypotonia and furrowed tongue.

Autism

autisticautistic disorderautistic children
MPAs have been studied in autism, Down syndrome, and in schizophrenia.

Low-set ears

low set earslow-set
Minor physical anomalies (MPAs) are relatively minor (typically painless and, in themselves, harmless) congenital physical abnormalities consisting of features such as low-set ears, single transverse palmar crease, telecanthus, micrognathism, macrocephaly, hypotonia and furrowed tongue.

Single transverse palmar crease

Simian creaseAbnormal palmar creasespalm prints
Minor physical anomalies (MPAs) are relatively minor (typically painless and, in themselves, harmless) congenital physical abnormalities consisting of features such as low-set ears, single transverse palmar crease, telecanthus, micrognathism, macrocephaly, hypotonia and furrowed tongue.

Telecanthus

intercanthal distance
Minor physical anomalies (MPAs) are relatively minor (typically painless and, in themselves, harmless) congenital physical abnormalities consisting of features such as low-set ears, single transverse palmar crease, telecanthus, micrognathism, macrocephaly, hypotonia and furrowed tongue.

Micrognathism

micrognathiaagnathiaSmall jaw size
Minor physical anomalies (MPAs) are relatively minor (typically painless and, in themselves, harmless) congenital physical abnormalities consisting of features such as low-set ears, single transverse palmar crease, telecanthus, micrognathism, macrocephaly, hypotonia and furrowed tongue.

Macrocephaly

macrocephaliclarge headan enlarged head
Minor physical anomalies (MPAs) are relatively minor (typically painless and, in themselves, harmless) congenital physical abnormalities consisting of features such as low-set ears, single transverse palmar crease, telecanthus, micrognathism, macrocephaly, hypotonia and furrowed tongue.

Hypotonia

low muscle tonefloppy infant syndromepoor muscle tone
Minor physical anomalies (MPAs) are relatively minor (typically painless and, in themselves, harmless) congenital physical abnormalities consisting of features such as low-set ears, single transverse palmar crease, telecanthus, micrognathism, macrocephaly, hypotonia and furrowed tongue.

Fissured tongue

development of folds and furrows in the tongue (fissured tongue)fissuredfurrowed tongue
Minor physical anomalies (MPAs) are relatively minor (typically painless and, in themselves, harmless) congenital physical abnormalities consisting of features such as low-set ears, single transverse palmar crease, telecanthus, micrognathism, macrocephaly, hypotonia and furrowed tongue.

Hypoxia (medical)

hypoxiahypoxicanoxia
While MPAs may have a genetic basis, they might also be caused by factors in the fetal environment: anoxia, bleeding, or infection.

Infection

infectious diseaseinfectious diseasesinfections
While MPAs may have a genetic basis, they might also be caused by factors in the fetal environment: anoxia, bleeding, or infection.

Pregnancy

pregnantfirst trimesterpregnant women
MPAs have been linked to disorders of pregnancy and are thought by some to be a marker for insults to the fetal neural development towards the end of the first trimester.

Development of the nervous system

neural developmentbrain developmentneurodevelopment
Thus, in the neurodevelopmental literature, they are seen as indirect indications of interferences with brain development.

Down syndrome

Down's syndrometrisomy 21Downs Syndrome
MPAs have been studied in autism, Down syndrome, and in schizophrenia.

Schizophrenia

schizophrenicschizophrenicspositive symptoms
MPAs have been studied in autism, Down syndrome, and in schizophrenia.

Meta-analysis

meta-analysesmeta analysismeta-analytic
A 2008 meta-analysis found that MPAs are significantly increased in the autistic population.

Craniofacial

craniomaxillofacial complex
A 1998 study found that 60% of its schizophrenic sample and 38% of their siblings had 6 or more MPAs (especially in the craniofacial area), while only 5% of the control group showed that many.

Cleft lip and cleft palate

cleft palatecleft lipcleft lip and palate
The most often cited MPA, high arched palate, is described in articles as a microform of a cleft palate.

Exotropia

divergent strabismusexotropesExotropic
Exotropia is reported as having low correlation and high significance as well.

Incidental imaging finding

incidentalomaAdrenal incidentalomaincidental finding
* Incidentaloma