A report on OpiateMorphine and Opioid receptor

Harvesting the poppy pod.
A localized reaction to intravenous morphine caused by histamine release in the veins
An animated view of the human κ-opioid receptor in complex with the antagonist JDTic.
A chart outlining the structural features that define opiates and opioids, including distinctions between semi-synthetic and fully synthetic opiate structures
Before the Morphine by Santiago Rusiñol
Morphine Hydrochloride Ampoule for Veterinary Use
Chemical structure of morphine
Latex bleeding from a freshly-scored seed pod
Morphine addiction cure advertisement in the year 1900
Morphine biosynthesis in the opium poppy
Chemical structure of morphine. The benzylisoquinoline backbone is shown in green.
Morphine structure showing its standard ring lettering and carbon numbering system.
Same structure, but in a three-dimensional perspective.
First generation production of alkaloids from licit latex-derived opium
Friedrich Sertürner
Advertisement for curing morphine addiction, c. 1900
An ampoule of morphine with integral needle for immediate use. Also known as a "syrette". From WWII. On display at the Army Medical Services Museum.
Example of different morphine tablets
Two capsules (5 mg & 10 mg) of morphine sulfate extended- release
1 milliliter ampoule containing 10 mg of morphine

Morphine is a pain medication of the opiate family that is found naturally in opium, a dark brown resin in poppies (Papaver somniferum).

- Morphine

In more modern usage, the term opioid is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain (including antagonists).

- Opiate

The psychoactive compounds found in the opium plant include morphine, codeine, and thebaine.

- Opiate

By the mid-1960s, it had become apparent from pharmacologic studies that opiate drugs were likely to exert their actions at specific receptor sites, and that there were likely to be multiple such sites.

- Opioid receptor

Social attachment was demonstrated to be mediated by the opioid system through experiments administering morphine and naltrexone, an opioid agonist and antagonist, to juvenile guinea pigs.

- Opioid receptor

Heroin is converted to morphine before binding to the opioid receptors in the brain and spinal cord, where morphine causes the subjective effects, which is what the addicted individuals are seeking.

- Morphine
Harvesting the poppy pod.

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Chemical structure of morphine, the prototypical opioid.


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Chemical structure of morphine, the prototypical opioid.
US. Top line represents the number of benzodiazepine deaths that also involved opioids. Bottom line represents benzodiazepine deaths that did not involve opioids.
Locants of the morphine molecule
INTA: selective agonist of KOR-DOR and KOR-MOR heteromers. Does not recruit β-arrestin II. Antinociceptive devoid of aversion, tolerance, and dependence in mice.
A sample of raw opium
US yearly deaths from all opioid drugs. Included in this number are opioid analgesics, along with heroin and illicit .<ref name=NIDA-deaths/>
US yearly deaths involving other, predominately Fentanyl.<ref name=NIDA-deaths/>
US yearly deaths involving prescription opioids. is a category dominated by illegally acquired fentanyl, and has been excluded.<ref name=NIDA-deaths>Overdose Death Rates. By National Institute on Drug Abuse (NIDA).</ref>
US yearly overdose deaths involving heroin.<ref name=NIDA-deaths/>

Opioids are substances that act on opioid receptors to produce morphine-like effects.

Opioids include opiates, an older term that refers to such drugs derived from opium, including morphine itself.