A report on Morphine and Opioid

A localized reaction to intravenous morphine caused by histamine release in the veins
Chemical structure of morphine, the prototypical opioid.
Before the Morphine by Santiago Rusiñol
US. Top line represents the number of benzodiazepine deaths that also involved opioids. Bottom line represents benzodiazepine deaths that did not involve opioids.
Morphine Hydrochloride Ampoule for Veterinary Use
Locants of the morphine molecule
Latex bleeding from a freshly-scored seed pod
INTA: selective agonist of KOR-DOR and KOR-MOR heteromers. Does not recruit β-arrestin II. Antinociceptive devoid of aversion, tolerance, and dependence in mice.
Morphine biosynthesis in the opium poppy
A sample of raw opium
Chemical structure of morphine. The benzylisoquinoline backbone is shown in green.
US yearly deaths from all opioid drugs. Included in this number are opioid analgesics, along with heroin and illicit .<ref name=NIDA-deaths/>
Morphine structure showing its standard ring lettering and carbon numbering system.
US yearly deaths involving other, predominately Fentanyl.<ref name=NIDA-deaths/>
Same structure, but in a three-dimensional perspective.
US yearly deaths involving prescription opioids. is a category dominated by illegally acquired fentanyl, and has been excluded.<ref name=NIDA-deaths>Overdose Death Rates. By National Institute on Drug Abuse (NIDA).</ref>
First generation production of alkaloids from licit latex-derived opium
US yearly overdose deaths involving heroin.<ref name=NIDA-deaths/>
Friedrich Sertürner
Advertisement for curing morphine addiction, c. 1900
An ampoule of morphine with integral needle for immediate use. Also known as a "syrette". From WWII. On display at the Army Medical Services Museum.
Example of different morphine tablets
Two capsules (5 mg & 10 mg) of morphine sulfate extended- release
1 milliliter ampoule containing 10 mg of morphine

Opioids are substances that act on opioid receptors to produce morphine-like effects.

- Opioid

About 70 percent of morphine is used to make other opioids such as hydromorphone, oxymorphone, and heroin.

- Morphine
A localized reaction to intravenous morphine caused by histamine release in the veins

42 related topics with Alpha

Overall

Heroin paraphernalia in a Jack Daniels tin

Heroin

18 links

Heroin paraphernalia in a Jack Daniels tin
Advertising sign from Bayer for use in US drug stores, dating from before the federal prohibition of Heroin in 1924
A 2010 study ranking various illegal and legal drugs based on statements by drug-harm experts. Heroin was found to be the second overall most dangerous drug.
Short-term effects of usage
Long-term effects of intravenous usage, including – and indeed primarily because of – the effects of the contaminants common in illegal heroin and contaminated needles.
Black tar heroin
Advertisement for Bayer Heroin
Bayer Heroin bottle
International drug routes
Afghanistan opium poppy cultivation, 1994–2016 (hectares)
Primary worldwide producers of heroin
Addiction experts in psychiatry, chemistry, pharmacology, forensic science, epidemiology, and the police and legal services engaged in delphic analysis regarding 20 popular recreational drugs. Heroin was ranked 1st in dependence, physical harm, and social harm.
Drug overdoses killed more than 70,200 in the US in 2017, with heroin involved in 15,482 of those deaths.<ref name=NIDA-deaths>{{cite web | url = http://www.drugabuse.gov/related-topics/trends-statistics/overdose-death-rates | title = Overdose Death Rates | archive-url = https://web.archive.org/web/20151128091723/http://www.drugabuse.gov/related-topics/trends-statistics/overdose-death-rates | archive-date=28 November 2015 | work = National Institute on Drug Abuse (NIDA) }}</ref>
US yearly overdose deaths involving heroin.<ref name=NIDA-deaths/>
US yearly deaths from all opioid drugs. Included in this number are opioid analgesics, along with heroin and illicit .<ref name=NIDA-deaths/>

Heroin, also known as diacetylmorphine and diamorphine among other names, is an opioid used as a recreational drug for its euphoric effects.

Black tar heroin is a variable admixture of morphine derivatives—predominantly 6-MAM (6-monoacetylmorphine), which is the result of crude acetylation during clandestine production of street heroin.

Oxycodone

12 links

A liquid solution containing 10mg of oxycodone per 1ml
Main side effects of oxycodone
Two tablets (10 mg) of oxycodone and safety blisters
Canadian oxycodone HCL/acetaminophen 5/325 mg tablet

Oxycodone, sold under the brand names Roxicodone and OxyContin (which is the extended release form) among others, is a semi-synthetic opioid medication used for treatment of moderate to severe pain.

When taken by mouth, it has roughly 1.5 times the effect of the equivalent amount of morphine.

The recreational drug lean can be created with codeine syrup (pictured).

Codeine

10 links

The recreational drug lean can be created with codeine syrup (pictured).

Codeine is an opiate and prodrug of morphine used to treat pain, coughing, and diarrhea.

Codeine is a nonsynthetic opioid.

Opium poppies such as this one provide ingredients for the class of analgesics called opiates

Analgesic

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Analgesic, pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain .

Analgesic, pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain .

Opium poppies such as this one provide ingredients for the class of analgesics called opiates
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In combination with opioid pain medication, paracetamol is now used for more severe pain such as cancer pain and after surgery.

Morphine, the archetypal opioid, and other opioids (e.g., codeine, oxycodone, hydrocodone, dihydromorphine, pethidine) all exert a similar influence on the cerebral opioid receptor system.

U.S. Food and Drug Administration agents inspect packages for illegal drug shipments at an international mail facility in New York

Controlled Substances Act

13 links

Statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated.

Statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated.

U.S. Food and Drug Administration agents inspect packages for illegal drug shipments at an international mail facility in New York

Heroin, is the brand name for diacetylmorphine or morphine diacetate, which is an inactive prodrug that exerts its effects after being converted into the major active metabolite morphine, and the minor metabolite 6-MAM - which itself is also rapidly converted to morphine. Some European countries still use it as a potent pain reliever in terminal cancer patients, and as second option, after morphine sulfate; it is about twice as potent, by weight, as morphine and, indeed, becomes morphine upon injection into the bloodstream. The two acetyl groups attached to the morphine make a prodrug which delivers morphine to the opioid receptors twice as fast as morphine can.

Fentanyl and most other strong pure opioid agonists, e.g. levorphanol

Hydromorphone

7 links

Hydromorphone, also known as dihydromorphinone, and sold under the brand name Dilaudid among others, is an opioid used to treat moderate to severe pain.

Hydromorphone 2 mg IV is equivalent to approximately 10 mg morphine IV.

Active and inactive μ-opioid receptors

Pain management

7 links

Aspect of medicine and health care involving relief of pain in various dimensions, from acute and simple to chronic and challenging.

Aspect of medicine and health care involving relief of pain in various dimensions, from acute and simple to chronic and challenging.

Active and inactive μ-opioid receptors
Young children can indicate their level of pain by pointing to the appropriate face on a children's pain scale

The Center for Disease Control recommends that physical therapy and exercise can be prescribed as a positive alternative to opioids for decreasing one's pain in multiple injuries, illnesses, or diseases.

Morphine is the gold standard to which all narcotics are compared.

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Pethidine

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Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a synthetic opioid pain medication of the phenylpiperidine class.

Compared with morphine, pethidine was thought to be safer, carry a lower risk of addiction, and to be superior in treating the pain associated with biliary spasm or renal colic due to its putative anticholinergic effects.

Opium poppy seed pod exuding latex from a cut

Opium

5 links

Dried latex obtained from the seed capsules of the opium poppy Papaver somniferum.

Dried latex obtained from the seed capsules of the opium poppy Papaver somniferum.

Opium poppy seed pod exuding latex from a cut
Poppy crop from the Malwa in India (probably Papaver somniferum var. album )
Opium users in Java during the Dutch colonial period c. 1870
Latin translation of Avicenna's Canon of Medicine, 1483
An artist's view of an Ottoman opium seller
An opium den in 18th-century China through the eyes of a Western artist
A Chinese opium house, photograph 1902
Destruction of opium at Humen, June 1839
British opium ships
British assault on Canton during the First Opium War, May 1841
Storage of opium at a British East India Company warehouse, c. 1850
The cover page of the book of The Truth about Opium Smoking
Map showing the amount of opium produced in China in 1908: The quote "We English, by the policy we have pursued, are morally responsible for every acre of land in China which is withdrawn from the cultivation of grain and devoted to that of the poppy; so that the fact of the growth of the drug in China ought only to increase our sense of responsibility." is by Lord Justice Fry.
Apothecary vessel for storage of opium as a pharmaceutical, Germany, 18th or 19th century
Modern vial of morphine first isolated from opium by Friedrich Sertürner
Harvesting opium
International drug routes
Afghanistan, Helmand province. A Marine greets local children working in the field of opium poppies near the base.
Afghanistan opium poppy cultivation, 1994–2016 (hectares)
200 g Spanish opium ball
An Akha man smokes a pipe containing opium mixed with tobacco

Approximately 12 percent of opium is made up of the analgesic alkaloid morphine, which is processed chemically to produce heroin and other synthetic opioids for medicinal use and for the illegal drug trade.

Fentanyl

7 links

A fentanyl nasal spray with a strength of 100 μg per use
A fentanyl transdermal patch with a release rate of 12 micrograms per hour, on a person's arm
US yearly overdose deaths, and some of the drugs involved. Among the more than 70,200 deaths estimated in 2017, the sharpest increase occurred among deaths related to fentanyl and fentanyl analogs (other ) with over 28,400 overdose deaths.
US yearly deaths involving other, predominantly fentanyl.
A package of 30 tablets, 600 mcg of fentanyl, each
Fentanyl powder (23% fentanyl) seized by a sheriff

Fentanyl, also spelled fentanil, is a powerful opioid used as a pain medication and, together with other medications, for anesthesia.

It is around 100 times stronger than morphine and about 50 times stronger than heroin.