Multiple organ dysfunction syndrome

Many of the internal organs of the human body

Altered organ function in an acutely ill patient requiring medical intervention to achieve homeostasis.

- Multiple organ dysfunction syndrome

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Septic shock

Potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism.

Sepsis is one of the most common causes of death in critically ill patients in Intensive Care Units. (Oil by Gabriël Metsu).
Thrombocytopenia with purpura on right hand in patient with septic shock

It can cause multiple organ dysfunction syndrome (formerly known as multiple organ failure) and death.

Systemic inflammatory response syndrome

Inflammatory state affecting the whole body.

The cardinal signs of inflammation include: pain, heat, redness, swelling, and loss of function. Some of these indicators can be seen here due to an allergic reaction.

Multiple organ dysfunction syndrome

Major trauma

Any injury that has the potential to cause prolonged disability or death.

Health care providers attending to a person on a stretcher with a gunshot wound to the head; the patient is intubated, and a mechanical ventilator is visible in the background
Radiograph of a close-range shotgun blast injury to the knee. Birdshot pellets are visible within and around the shattered patella, distal femur, and proximal tibia
Whole body radiograph of traumatic injuries notable for fractures of both femurs (thigh bones), indicating major trauma
A Navy corpsmen listens for the correct tube placement on an intubated trauma victim during a search and rescue exercise
Typical trauma room
Incidence of accidents by activity in Denmark

Prolonged inflammation may cause multiple organ dysfunction syndrome or systemic inflammatory response syndrome.

Oliguria

Low output of urine specifically more than 80 ml/day but less than 400ml/day.

Sample of human urine

The decreased output of urine may be a sign of dehydration, kidney failure, hypovolemic shock, hyperosmolar hyperglycemic nonketotic syndrome (HHNS), multiple organ dysfunction syndrome, urinary obstruction/urinary retention, diabetic ketoacidosis (DKA), pre-eclampsia, and urinary tract infections, among other conditions.

Sepsis

Life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs.

Skin blotching and inflammation due to sepsis
Blood culture bottles: orange cap for anaerobes, green cap for aerobes, and yellow cap for blood samples from children
Sepsis Steps. Training tool for teaching the progression of sepsis stages
Intravenous fluids being given
Personification of septicemia, carrying a spray can marked "Poison"
Phenotypic strategy switches of microbes capable of provoking sepsis

Subsequently, multiple organ failure ensues because tissues are unable to use oxygen efficiently due to inhibition of cytochrome c oxidase.

Cytokine

Cytokines are a broad and loose category of small proteins (~5–25 kDa ) important in cell signaling.

3D medical animation still showing secretion of cytokines

Cytokines are integral and implicated in all angles of the cascade, resulting in the systemic inflammatory response syndrome and multi-organ failure associated with this intra-abdominal catastrophe.

Yellow fever

Viral disease of typically short duration.

A TEM micrograph of yellow fever virus (234,000× magnification)
Aedes aegypti feeding
Adults of the yellow fever mosquito A. aegypti: The male is on the left, females are on the right. Only the female mosquito bites humans to transmit the disease.
The cover of a certificate that confirms the holder has been vaccinated against yellow fever
Information campaign for prevention of dengue and yellow fever in Paraguay
Areas with risk of yellow fever in Africa (2017)
Areas with risk of yellow fever in South America (2018)
Sugar curing house, 1762: Sugar pots and jars on sugar plantations served as breeding place for larvae of A. aegypti, the vector of yellow fever.
Headstones of people who died in the yellow fever epidemic of 1878 can be found in New Orleans' cemeteries
A page from Commodore James Biddle's list of the 76 dead (74 of yellow fever) aboard the USS Macedonian, dated 3 August 1822
Yellow fever in Buenos Aires, 1871
Carlos Finlay
Walter Reed
Max Theiler

Fatality may occur when cytokine storm, shock, and multiple organ failure follow.

George Best

Northern Irish professional footballer who played as a winger, spending most of his club career at Manchester United.

Best with Northern Ireland in 1976
Best grew up on the Cregagh estate, east Belfast. The playing fields in the estate where he played football as a boy, Cregagh Green, is protected for community recreation in perpetuity as a Fields in Trust Active Space.
George Best memorabilia at the Manchester United museum at Old Trafford
Best (middle) in Rotterdam, the Netherlands, October 1976
Best in Hong Kong in 1982
Mural of George Best in Belfast in his dribbling pose.
Gates of Belfast City Hall soon after Best's death, [[:File:Cityhall2.jpg|Another view]].
Best's grave at Roselawn Cemetery, overlooking east Belfast

In the early hours of 25 November 2005, treatment was stopped; later that day he died, aged 59, as a result of a lung infection and multiple organ failure.

Organ dysfunction

Condition where an organ does not perform its expected function.

Many of the internal organs of the human body

Multiple organ failure can be associated with sepsis and is often fatal.

Group A streptococcal infection

Infection with group A streptococcus .

Streptococcus pyogenes

All severe GAS infections may lead to shock, multisystem organ failure, and death.