Microscopy of a cell with neurofibrillary tangles (marked by arrows).
Diagram of how microtubules disintegrate with Alzheimer's disease
Overview of RNA interference.

Primary age-related tauopathy (PART) is a neuropathological designation introduced in 2014 to describe the neurofibrillary tangles (NFT) that are commonly observed in the brains of normally aged and cognitively impaired individuals that can occur independently of the amyloid plaques of Alzheimer's disease (AD).

- Primary age-related tauopathy

It is currently unclear as to whether or not primary age-related tauopathy (PART), a term which includes some cases formerly referred to as neurofibrillary tangle-predominant dementia (NFTPD) or tangle-only dementia, is a variant of the traditional Alzheimer's disease, or a distinct entity.

- Neurofibrillary tangle
Microscopy of a cell with neurofibrillary tangles (marked by arrows).

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Diagram of a normal microtubule and one affected by tauopathy

Tauopathy

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Diagram of a normal microtubule and one affected by tauopathy
Diagram of a normal microtubule and one affected by tauopathy
Abnormal accumulation of tau protein in neuronal cell bodies (arrow) and neuronal extensions (arrowhead) in the neocortex of a patient who died with Alzheimer's disease. The bar = 25 microns (0.025 millimeters).

Tauopathy belongs to a class of neurodegenerative diseases involving the aggregation of tau protein into neurofibrillary or gliofibrillary tangles (Neurofibrillary tangle) in the human brain.

Primary age-related tauopathy (PART) dementia, with NFTs similar to AD, but without amyloid plaques.