Neurogenomics

Neurogenomics is the study of how the genome of an organism influences the development and function of its nervous system.wikipedia
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Omics

-omicsomic-ome
Consideration should be taken of the following factors when working with 'omics data collected from post-mortem brains:
Neurogenomics: Study of genetic influences on the development and function of the nervous system.

Istituto Italiano di Tecnologia

Italian Institute of Technology (IIT)IITItalian Institute of Technology of Genoa
The new research facilities will be dedicated to robotics, cognition motion, neuroscience, human-robot interaction, computational statistics, neurogenomics, neurodiagnostics, and other scientific areas.

Functional genomics

functionalgene functionfunction screens
This field intends to unite functional genomics and neurobiology in order to understand the nervous system as a whole from a genomic perspective.

Glia

glial cellsglial cellglial
The nervous system in vertebrates is made up of two major types of cells – neuroglial cells and neurons.

Neuron

neuronsnerve cellsnerve cell
The nervous system in vertebrates is made up of two major types of cells – neuroglial cells and neurons.

Brain

brain functionmammalian braincerebral
Hundreds of different types of neurons exist in humans, with varying functions – some of them process external stimuli; others generate a response to stimuli; others organize in centralized structures (brain, spinal ganglia) that are responsible for cognition, perception, and regulation of motor functions.

Dorsal root ganglion

dorsal root gangliasensory gangliaspinal ganglia
Hundreds of different types of neurons exist in humans, with varying functions – some of them process external stimuli; others generate a response to stimuli; others organize in centralized structures (brain, spinal ganglia) that are responsible for cognition, perception, and regulation of motor functions.

Gene expression profiling

expression profilinggene expression profilesexpression profile
Prior to the availability of expression arrays and DNA sequencing methodologies, researchers sought to understand the cellular behaviour of neurons (including synapse formation and neuronal development and regionalization in the human nervous system) in terms of the underlying molecular biology and biochemistry, without any understanding of the influence of a neuron’s genome on its development and behaviour.

Synapse

synapsessynapticrelease
Prior to the availability of expression arrays and DNA sequencing methodologies, researchers sought to understand the cellular behaviour of neurons (including synapse formation and neuronal development and regionalization in the human nervous system) in terms of the underlying molecular biology and biochemistry, without any understanding of the influence of a neuron’s genome on its development and behaviour.

Neuroscience

neurobiologyneuroscientistneurobiological
This field intends to unite functional genomics and neurobiology in order to understand the nervous system as a whole from a genomic perspective.

Neurogenetics

neurogeneticbehavioral neurogeneticsneurogeneticist
This approach is distinct from neurogenetics, which emphasizes the role of single genes without a network-interaction context when studying the nervous system. Notably, the association between behavioural patterns and high penetrance single gene loci falls under the purview of neurogenetics research, wherein the focus is to identify a simple causative relationship between a single, high penetrance gene and an observed function/behaviour.

Microarray

microarraysmicroarray analysishigh-density oligonucleotide probe arrays
In 1999, Cirelli & Tononi first reported the association of genome-wide brain gene expression profiling (using microarrays) with a behavioural phenotype in mice.

Non-coding RNA

RNAncRNAnon-coding RNAs
Furthermore, due to their probe-based nature, microarrays can miss out on many types of transcripts (ncRNAs, miRNAs, and mRNA isoforms).

MicroRNA

miRNAmicroRNAsmiRNAs
Furthermore, due to their probe-based nature, microarrays can miss out on many types of transcripts (ncRNAs, miRNAs, and mRNA isoforms).

Messenger RNA

mRNAmRNAsmessenger RNAs
Furthermore, due to their probe-based nature, microarrays can miss out on many types of transcripts (ncRNAs, miRNAs, and mRNA isoforms).

Protein isoform

isoformsisoformglycoform
Furthermore, due to their probe-based nature, microarrays can miss out on many types of transcripts (ncRNAs, miRNAs, and mRNA isoforms).

Locus (genetics)

locuslociq arm
Notably, the association between behavioural patterns and high penetrance single gene loci falls under the purview of neurogenetics research, wherein the focus is to identify a simple causative relationship between a single, high penetrance gene and an observed function/behaviour.

Gene

genesnumber of genesgene sequence
However, it has been shown that several neurological diseases tend to be polygenic, being influenced by multiple different genes and regulatory regions instead of one gene alone.

Regulatory sequence

regulatory elementsregulatory regionsregulatory sequences
However, it has been shown that several neurological diseases tend to be polygenic, being influenced by multiple different genes and regulatory regions instead of one gene alone.

DNA sequencing

sequencesequencingsequenced
Prior to the availability of expression arrays and DNA sequencing methodologies, researchers sought to understand the cellular behaviour of neurons (including synapse formation and neuronal development and regionalization in the human nervous system) in terms of the underlying molecular biology and biochemistry, without any understanding of the influence of a neuron’s genome on its development and behaviour.

Twin study

twin studiestwinstudies of twins
Twin studies have revealed that schizophrenia, bipolar disorder, autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD) are highly heritable, genetically complex psychiatric disorders.

Schizophrenia

schizophrenicschizophrenicspositive symptoms
Twin studies have revealed that schizophrenia, bipolar disorder, autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD) are highly heritable, genetically complex psychiatric disorders.

Bipolar disorder

bipolarmanic depressionmanic depressive
Twin studies have revealed that schizophrenia, bipolar disorder, autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD) are highly heritable, genetically complex psychiatric disorders.

Autism spectrum

autism spectrum disorderautisticautism spectrum disorders
Twin studies have revealed that schizophrenia, bipolar disorder, autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD) are highly heritable, genetically complex psychiatric disorders.

Mutation

mutationsgenetic mutationmutated
Several independently occurring de novo mutations in patients Alzheimer's Disease have been found to disrupt a shared set of functional pathways involved with neuronal signalling, for example.