Neuroimmune system

neuroimmuneneuroimmune disordersblood-nerve barrierneuroimmune functionneuroimmune responseneuroinflammatory processes
The neuroimmune system is a system of structures and processes involving the biochemical and electrophysiological interactions between the nervous system and immune system which protect neurons from pathogens.wikipedia
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Immune system

immuneimmune responseimmune function
The neuroimmune system is a system of structures and processes involving the biochemical and electrophysiological interactions between the nervous system and immune system which protect neurons from pathogens.
In humans, the blood–brain barrier, blood–cerebrospinal fluid barrier, and similar fluid–brain barriers separate the peripheral immune system from the neuroimmune system, which protects the brain.

Mast cell

mast cellsanaphylactic degranulationMast cell disease
Unlike the peripheral system, the neuroimmune system is composed primarily of glial cells; among all the hematopoietic cells of the immune system, only mast cells are normally present in the neuroimmune system. Unlike other hematopoietic cells of the peripheral immune system, mast cells naturally occur in the brain where they mediate interactions between gut microbes, the immune system, and the central nervous system as part of the microbiota–gut–brain axis.
Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.

TAAR1

trace amine-associated receptor 1TAAR1 agonisthTAAR1
TAAR1 plays a significant role in regulating neurotransmission in dopamine, norepinephrine, and serotonin neurons in the CNS; it also affects immune system and neuroimmune system function through different mechanisms.

Choroid plexus

blood–cerebrospinal fluid barrierchoroid plexusesvelum interpositum
It serves to protect neurons against disease by maintaining selectively permeable barriers (e.g., the blood–brain barrier and blood–cerebrospinal fluid barrier), mediating neuroinflammation and wound healing in damaged neurons, and mobilizing host defenses against pathogens.
This cellular trafficking has implications both in normal brain homeostasis as in neuroinflammatory processes.

Blood–brain barrier

blood-brain barrierblood brain barrierblood-brain-barrier
It serves to protect neurons against disease by maintaining selectively permeable barriers (e.g., the blood–brain barrier and blood–cerebrospinal fluid barrier), mediating neuroinflammation and wound healing in damaged neurons, and mobilizing host defenses against pathogens.

Microglia

microglial cellsmicroglialmicroglial cell
The key cellular components of the neuroimmune system are glial cells, including astrocytes, microglia, and oligodendrocytes.

Biomolecule

biochemicalbiomoleculesbiomolecular
The neuroimmune system is a system of structures and processes involving the biochemical and electrophysiological interactions between the nervous system and immune system which protect neurons from pathogens.

Electrophysiology

electrophysiologicalelectrophysiologistelectrophysiologic
The neuroimmune system is a system of structures and processes involving the biochemical and electrophysiological interactions between the nervous system and immune system which protect neurons from pathogens.

Nervous system

neuralnervousneurogenic
The neuroimmune system is a system of structures and processes involving the biochemical and electrophysiological interactions between the nervous system and immune system which protect neurons from pathogens.

Neuron

neuronsnerve cellsnerve cell
The neuroimmune system is a system of structures and processes involving the biochemical and electrophysiological interactions between the nervous system and immune system which protect neurons from pathogens.

Pathogen

pathogenspathogenicpathogenicity
The neuroimmune system is a system of structures and processes involving the biochemical and electrophysiological interactions between the nervous system and immune system which protect neurons from pathogens.

Neuroinflammation

neuroinflamationneuroinflammatory diseases
It serves to protect neurons against disease by maintaining selectively permeable barriers (e.g., the blood–brain barrier and blood–cerebrospinal fluid barrier), mediating neuroinflammation and wound healing in damaged neurons, and mobilizing host defenses against pathogens.

Wound healing

wound repairscabvulnerary
It serves to protect neurons against disease by maintaining selectively permeable barriers (e.g., the blood–brain barrier and blood–cerebrospinal fluid barrier), mediating neuroinflammation and wound healing in damaged neurons, and mobilizing host defenses against pathogens.

Blood cell

blood cellshematopoietic cellhemocyte
Unlike the peripheral system, the neuroimmune system is composed primarily of glial cells; among all the hematopoietic cells of the immune system, only mast cells are normally present in the neuroimmune system. Unlike other hematopoietic cells of the peripheral immune system, mast cells naturally occur in the brain where they mediate interactions between gut microbes, the immune system, and the central nervous system as part of the microbiota–gut–brain axis.

Macrophage

macrophagesM2 macrophagesTissue macrophages
For example, there is evidence that following injury macrophages and T cells of the immune system migrate into the spinal cord.

T cell

T cellsT-cellT-cells
For example, there is evidence that following injury macrophages and T cells of the immune system migrate into the spinal cord.

Complement system

complementcomplement cascadecomplement activation
Production of immune cells of the complement system have also been documented as being created directly in the central nervous system.

Glia

glial cellsglial cellglial
Unlike the peripheral system, the neuroimmune system is composed primarily of glial cells; among all the hematopoietic cells of the immune system, only mast cells are normally present in the neuroimmune system. The key cellular components of the neuroimmune system are glial cells, including astrocytes, microglia, and oligodendrocytes.

Astrocyte

astrocytesastrogliaastrocytic
The key cellular components of the neuroimmune system are glial cells, including astrocytes, microglia, and oligodendrocytes.

Gut–brain axis

gut-brain axisbiochemical signaling that takes place between the gastrointestinal tract and the central nervous systembrain-gut
Unlike other hematopoietic cells of the peripheral immune system, mast cells naturally occur in the brain where they mediate interactions between gut microbes, the immune system, and the central nervous system as part of the microbiota–gut–brain axis.

Chemokine

chemokinesCC chemokineCC chemokines
Following injury or infection, there is a cascade of inflammatory responses such as the secretion of cyotkines and chemokines that couple with the secretion of neuropeptides (such as substance P) and neurotransmitters (such as serotonin).