Non-receptor tyrosine kinase

EC 2.7.10.2Ncknon receptor tyrosine kinasesnon-receptor TKnon-specific protein-tyrosine kinasenonreceptor tyrosine kinasenonreceptor tyrosine kinasestyrosine kinase non-receptor 2
Non-receptor tyrosine kinases (nRTKs) are cytosol ic enzymes that are responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate donor, such as ATP, to tyrosine residues in proteins.wikipedia
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Receptor tyrosine kinase

receptor tyrosine kinasestyrosine kinase receptortyrosine kinase receptors
Unlike the receptor tyrosine kinases (RTKs), the second subgroup of tyrosine kinases, the non-receptor tyrosine kinases are cytosolic enzymes.
Receptor tyrosine kinases are part of the larger family of protein tyrosine kinases, encompassing the receptor tyrosine kinase proteins which contain a transmembrane domain, as well as the non receptor tyrosine kinases which do not possess transmembrane domains.

Proto-oncogene tyrosine-protein kinase Src

Srcc-Srcv-src
CD4 and CD8 receptors on T lymphocytes require for their signaling the Src family member Lck.
Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src, is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene.

Janus kinase 2

JAK22JAK
In contrast, another mutant of the Jak family Jak2, also lacking the pseudo-kinase domain, was able to mediate growth hormone signaling.
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase.

Src family kinase

SRCSrc family kinasesSrc-family kinase
Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily.

Cytosol

cytosolichyaloplasmintracellular fluid
Non-receptor tyrosine kinases (nRTKs) are cytosol ic enzymes that are responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate donor, such as ATP, to tyrosine residues in proteins.

Enzyme

enzymologyenzymesenzymatic
Non-receptor tyrosine kinases (nRTKs) are cytosol ic enzymes that are responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate donor, such as ATP, to tyrosine residues in proteins.

Phosphate

phosphatesphosphate groupinorganic phosphate
Non-receptor tyrosine kinases (nRTKs) are cytosol ic enzymes that are responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate donor, such as ATP, to tyrosine residues in proteins.

Nucleoside triphosphate

dNTPnucleotide triphosphateNTP
Non-receptor tyrosine kinases (nRTKs) are cytosol ic enzymes that are responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate donor, such as ATP, to tyrosine residues in proteins.

Adenosine triphosphate

ATPadenosine triphosphate (ATP)adenosine 5'-triphosphate
Non-receptor tyrosine kinases (nRTKs) are cytosol ic enzymes that are responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate donor, such as ATP, to tyrosine residues in proteins.

Protein

proteinsproteinaceousstructural proteins
Non-receptor tyrosine kinases (nRTKs) are cytosol ic enzymes that are responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate donor, such as ATP, to tyrosine residues in proteins.

Tyrosine kinase

tyrosine kinasesprotein-tyrosine kinaseprotein tyrosine kinase
Non-receptor tyrosine kinases are a subgroup of protein family tyrosine kinases, enzymes that can transfer the phosphate group from ATP to a tyrosine residue of a protein (phosphorylation).

Apoptosis

apoptoticprogrammed cell deathcell death
Non-receptor tyrosine kinases regulate cell growth, proliferation, differentiation, adhesion, migration and apoptosis, and they are critical components in the regulation of the immune system.

Immune system

immuneimmune responseimmune function
Non-receptor tyrosine kinases regulate cell growth, proliferation, differentiation, adhesion, migration and apoptosis, and they are critical components in the regulation of the immune system.

Signal transduction

signaling pathwayssignaling cascadesignal transduction pathways
The main function of nRTKs is their involvement in signal transduction in activated T- and B-cells in the immune system.

B cell

B cellsB-cellB lymphocytes
The main function of nRTKs is their involvement in signal transduction in activated T- and B-cells in the immune system.

T-cell receptor

T cell receptorTCRT-cell receptors
Signaling by many receptors is dependent on nRTKs including T-cell receptors (TCR), B-cell receptors (BCR), IL-2 receptors (IL-2R), Ig receptors, erythropoietin (EpoR) and prolactin receptors.

B-cell receptor

B cell receptorBCRB-cell
Signaling by many receptors is dependent on nRTKs including T-cell receptors (TCR), B-cell receptors (BCR), IL-2 receptors (IL-2R), Ig receptors, erythropoietin (EpoR) and prolactin receptors.

IL-2 receptor

IL-2interleukin-2 receptorIL-2R
Signaling by many receptors is dependent on nRTKs including T-cell receptors (TCR), B-cell receptors (BCR), IL-2 receptors (IL-2R), Ig receptors, erythropoietin (EpoR) and prolactin receptors.

Erythropoietin receptor

EPOREpo-Rerythropoietin (EPO) receptor
Signaling by many receptors is dependent on nRTKs including T-cell receptors (TCR), B-cell receptors (BCR), IL-2 receptors (IL-2R), Ig receptors, erythropoietin (EpoR) and prolactin receptors.

Prolactin receptor

PRLRPRL receptorPRL-R
Signaling by many receptors is dependent on nRTKs including T-cell receptors (TCR), B-cell receptors (BCR), IL-2 receptors (IL-2R), Ig receptors, erythropoietin (EpoR) and prolactin receptors.

CD4

CD4+CD4 + CD4 count
CD4 and CD8 receptors on T lymphocytes require for their signaling the Src family member Lck.

CD8

CD8 + CD8+CD8B
CD4 and CD8 receptors on T lymphocytes require for their signaling the Src family member Lck.

T cell

T cellsT-cellT-cells
CD4 and CD8 receptors on T lymphocytes require for their signaling the Src family member Lck. The main function of nRTKs is their involvement in signal transduction in activated T- and B-cells in the immune system.

Lck

lymphocyte specific protein tyrosine kinase p56(lck)lymphocyte-specific protein tyrosine kinase
CD4 and CD8 receptors on T lymphocytes require for their signaling the Src family member Lck.

Cytokine

cytokineschemical signalscytokine-
When antigen binds to T-cell receptor, Lck becomes autophosphorylated and phosphorylates the zeta chain of the T-cell receptor, subsequently another nRTK, Zap70, binds to this T-cell receptor and then participates in downstream signaling events that mediate transcriptional activation of cytokine genes.