Norgestimate

Ethinylestradiol/norgestimatePrefest
Norgestimate, sold under the brand names Ortho Tri-Cyclen and Previfem among others, is a progestin medication which is used in birth control pills for women and in menopausal hormone therapy.wikipedia
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Combined oral contraceptive pill

birth control pillthe pillbirth control pills
Norgestimate, sold under the brand names Ortho Tri-Cyclen and Previfem among others, is a progestin medication which is used in birth control pills for women and in menopausal hormone therapy.
The risk of thromboembolism varies with different types of birth control pills; compared with combined oral contraceptives containing levonorgestrel (LNG), and with the same dose of estrogen and duration of use, the rate ratio of deep venous thrombosis for combined oral contraceptives with norethisterone is 0.98, with norgestimate 1.19, with desogestrel (DSG) 1.82, with gestodene 1.86, with drospirenone (DRSP) 1.64, and with cyproterone acetate 1.88.

Norelgestromin

Norelgestromin (17β-deacetylnorgestimate, norgestrel 3-oxime)
The medication is a prodrug of norelgestromin and to a lesser extent of levonorgestrel in the body. Norgestimate is a rapidly and completely converted prodrug, mainly of norelgestromin (17β-deacetylnorgestimate or levonorgestrel 3-oxime), but also of levonorgestrel (3-keto-17β-deacetylnorgestimate) to a lesser extent (22 ± 6% of an administered dose or about 40–70 µg) and of levonorgestrel acetate (levonorgestrel 17β-acetate) in very small amounts.
It is one of the active metabolites of norgestimate.

Progestin

progestinsprogestogen
Norgestimate, sold under the brand names Ortho Tri-Cyclen and Previfem among others, is a progestin medication which is used in birth control pills for women and in menopausal hormone therapy.
Alternatively, estranes such as noretynodrel and norethisterone are classified as first-generation while gonanes such as norgestrel and levonorgestrel are classified as second-generation, with less androgenic gonanes such as desogestrel, norgestimate, and gestodene classified as third-generation and newer progestins like drospirenone classified as fourth-generation.

Levonorgestrel acetate

Levonorgestrel 17β-acetate
Norgestimate is a rapidly and completely converted prodrug, mainly of norelgestromin (17β-deacetylnorgestimate or levonorgestrel 3-oxime), but also of levonorgestrel (3-keto-17β-deacetylnorgestimate) to a lesser extent (22 ± 6% of an administered dose or about 40–70 µg) and of levonorgestrel acetate (levonorgestrel 17β-acetate) in very small amounts.
Norgestimate is the C3 oxime of LNG-A.

Gestodene

Gestodene (15-dehydronorgestrel)
The relative binding affinity of norgestimate and its metabolite norelgestromin for the rat prostatic androgen receptor (AR) are 0.3% and 1.3% of those of dihydrotestosterone (DHT), respectively, whereas the respective values for levonorgestrel and gestodene are 22% and 15%.
Unlike other third-generation progestins like desogestrel and norgestimate, gestodene is not a prodrug.

Sex hormone-binding globulin

SHBGsex hormone binding globulinEstradiol-binding protein
In addition, although levonorgestrel binds to the progesterone receptor with much higher affinity than norelgestromin, levonorgestrel has high affinity for sex hormone-binding globulin (SHBG) (87% of that of testosterone), which may limit its activity, whereas norelgestromin does not bind to SHBG.

Nandrolone

19-nortestosteroneDeca-Durabolinnandralone
However, the medication shows less androgenic activity than related 19-nortestosterone progestins like levonorgestrel and norethisterone.
The estranes include norethisterone (norethindrone), norethisterone acetate, norethisterone enanthate, lynestrenol, etynodiol diacetate, and noretynodrel, while the gonanes include norgestrel, levonorgestrel, desogestrel, etonogestrel, gestodene, norgestimate, dienogest (actually a 17α-cyanomethyl-19-nortestosterone derivative), and norelgestromin.

Norethisterone

ErrinMicronorNorethisterone (norethindrone)
However, the medication shows less androgenic activity than related 19-nortestosterone progestins like levonorgestrel and norethisterone.

Hormone replacement therapy

menopausal hormone therapyhormone therapyestrogen replacement therapy
Norgestimate, sold under the brand names Ortho Tri-Cyclen and Previfem among others, is a progestin medication which is used in birth control pills for women and in menopausal hormone therapy.

Estrogen (medication)

estrogenEstrogenicestrogen cream
The medication is available in combination with an estrogen and is not available alone.

Side effect

side effectsside-effectsside-effect
Side effects of the combination of an estrogen and norgestimate include menstrual irregularities, headaches, nausea, abdominal pain, breast tenderness, mood changes, and others.

Irregular menstruation

menstrual irregularitiesmenstrual irregularityirregular
Side effects of the combination of an estrogen and norgestimate include menstrual irregularities, headaches, nausea, abdominal pain, breast tenderness, mood changes, and others.

Headache

headacheschronic headacheheadach
Side effects of the combination of an estrogen and norgestimate include menstrual irregularities, headaches, nausea, abdominal pain, breast tenderness, mood changes, and others.

Nausea

nauseousnauseatedvomiting
Side effects of the combination of an estrogen and norgestimate include menstrual irregularities, headaches, nausea, abdominal pain, breast tenderness, mood changes, and others.

Abdominal pain

stomach acheupset stomachabdominal discomfort
Side effects of the combination of an estrogen and norgestimate include menstrual irregularities, headaches, nausea, abdominal pain, breast tenderness, mood changes, and others.

Mood (psychology)

moodmoodsatmosphere
Side effects of the combination of an estrogen and norgestimate include menstrual irregularities, headaches, nausea, abdominal pain, breast tenderness, mood changes, and others.

Organic compound

syntheticorganicorganic compounds
Norgestimate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.

Progestogen

progestogensprogestationalgestagen
Norgestimate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.

Agonist

full agonistagonistsreceptor agonist
Norgestimate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.

Progesterone receptor

progesteronePRPGR
Norgestimate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.

Biological target

drug targettargettherapeutic target
Norgestimate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.

Progesterone

EndometrinprogestationalProgesterone for prevention of preterm birth
Norgestimate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.

Androgen

androgensandrogenicAndrogenic steroid
It has very weak androgenic activity and no other important hormonal activity.

Prodrug

pro-drugprodrugsinactive prodrug
The medication is a prodrug of norelgestromin and to a lesser extent of levonorgestrel in the body. Norgestimate is a rapidly and completely converted prodrug, mainly of norelgestromin (17β-deacetylnorgestimate or levonorgestrel 3-oxime), but also of levonorgestrel (3-keto-17β-deacetylnorgestimate) to a lesser extent (22 ± 6% of an administered dose or about 40–70 µg) and of levonorgestrel acetate (levonorgestrel 17β-acetate) in very small amounts.