Notch 1

NOTCH1Notch-1
Notch homolog 1, translocation-associated (Drosophila), also known as NOTCH1, is a human gene encoding a single-pass transmembrane receptor.wikipedia
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Notch signaling pathway

NotchNotch signalingNotch receptor
This gene encodes a member of the Notch family.
Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4.

Reelin

RELNpsychotropic medication itself affects reelin expressionReelin protein
One study shows that Notch-1 cascade is activated by Reelin in an unidentified way.
Reelin activates the signaling cascade of Notch-1, inducing the expression of FABP7 and prompting progenitor cells to assume radial glial phenotype.

Bicuspid aortic valve

bicuspid valvecongenitally have two leaflets
A deficiency can be associated with bicuspid aortic valve.
Bicuspid aortic valve is a heritable condition, with a demonstrated association with mutations in the NOTCH1 gene.

NOV (gene)

NOVNephroblastoma overexpressedNOV/CCN3
It functions by direct binding to integrin receptors, as well as other receptors such as NOTCH1 and fibulin 1c (FBLN1).

GSK3B

GSK3βGSK-3βGlycogen Synthase Kinase 3 Beta

Lck

lymphocyte specific protein tyrosine kinase p56(lck)lymphocyte-specific protein tyrosine kinase

NFKB1

p50NF-κB protein complexNF-κB1

MAML1

Mastermind
MAML1 has been shown to interact with EP300 and NOTCH1.

YY1

USP10

In the endothelium, USP10 regulates Notch signaling by slowing down the degradation of the intracellular domain of NOTCH1.

Gene

genesnumber of genesgene sequence
Notch homolog 1, translocation-associated (Drosophila), also known as NOTCH1, is a human gene encoding a single-pass transmembrane receptor.

Receptor (biochemistry)

receptorreceptorscellular receptors
Notch homolog 1, translocation-associated (Drosophila), also known as NOTCH1, is a human gene encoding a single-pass transmembrane receptor.

Transmembrane protein

transmembranetransmembrane proteinstype I
Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types.

Epidermal growth factor

EGFepidermal growth factor (EGF)epidermal growth factor-1
Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types.

Conserved sequence

sequence conservationconservedhighly conserved
The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells.

Cell signaling

cell signallingsignallingsignaling pathway
The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells.

Drosophila

fruit fliesfruit flyDrosophilia
In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development.

Golgi apparatus

GolgiGolgi complextrans-Golgi network
This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer.

Notch 3

NOTCH33
There is evidence that activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.

Radial glial cell

radial gliaBergmann gliaRadial glial cells
Notch 1, when activated before birth, induces radial glia differentiation, but postnatally induces the differentiation into astrocytes.

Astrocyte

astrocytesastrogliaastrocytic
There is evidence that activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia. Notch 1, when activated before birth, induces radial glia differentiation, but postnatally induces the differentiation into astrocytes.

Dentate gyrus

band of Gaicominiband of Giacominidentate
Reelin and Notch1 cooperate in the development of the dentate gyrus, according to another.