Notch proteins

NotchNotch proteinNotch receptors
Notch proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway, which is highly conserved in metazoans.wikipedia
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Notch signaling pathway

NotchNotch signalingNotch receptor
Notch proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway, which is highly conserved in metazoans.
Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4.

O-linked glycosylation

O-glycosylationO''-linked glycosylationO-glycosylated
These repeats are heavily modified through O-glycoslyation and the addition of specific O-linked glycans has been shown to be necessary for proper function.
Notch is an important protein in development, with several EGF domains that are O-fucosylated.

Protein family

familyfamily of proteinsprotein families
Notch proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway, which is highly conserved in metazoans.

Transmembrane protein

transmembranetransmembrane proteinstype I
Notch proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway, which is highly conserved in metazoans.

Animal

Animaliaanimalsmetazoa
Notch proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway, which is highly conserved in metazoans.

Ectodomain

extracellular domainextracellular domainsmicroenvironments
The Notch extracellular domain (NECD) mediates interactions with DSL family ligands, allowing it to participate in juxtacrine signaling.The Notch intracellular domain (NICD) acts as a transcriptional activator when in complex with CSL family transcription factors.

Ligand

ligandsligand exchangebidentate ligand
The Notch extracellular domain (NECD) mediates interactions with DSL family ligands, allowing it to participate in juxtacrine signaling.The Notch intracellular domain (NICD) acts as a transcriptional activator when in complex with CSL family transcription factors.

Juxtacrine signalling

juxtacrinejuxtacrine signalingjuxtacrine interactions
The Notch extracellular domain (NECD) mediates interactions with DSL family ligands, allowing it to participate in juxtacrine signaling.The Notch intracellular domain (NICD) acts as a transcriptional activator when in complex with CSL family transcription factors.

Activator (genetics)

activatortranscriptional activatoractivators
The Notch extracellular domain (NECD) mediates interactions with DSL family ligands, allowing it to participate in juxtacrine signaling.The Notch intracellular domain (NICD) acts as a transcriptional activator when in complex with CSL family transcription factors.

Epidermal growth factor

EGFepidermal growth factor (EGF)epidermal growth factor-1
Members of this Type 1 transmembrane protein family share several core structures, including an extracellular domain consisting of multiple epidermal growth factor (EGF)-like repeats and an intracellular domain transcriptional activation domain (TAD).

Cell fate determination

cell fatefatescell determination
Notch family members operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions.

Caenorhabditis elegans

C. eleganswormsC.elegans
Much of what is known about Notch function comes from studies done in Caenorhabditis elegans (C.elegans) and Drosophila melanogaster. Human homologs have also been identified, but details of Notch function and interactions with its ligands are not well known in this context.

Drosophila melanogaster

fruit fliesDrosophilafruit fly
Much of what is known about Notch function comes from studies done in Caenorhabditis elegans (C.elegans) and Drosophila melanogaster. Human homologs have also been identified, but details of Notch function and interactions with its ligands are not well known in this context.

Mutant

mutantsmutatedsport
Notch was discovered in a mutant Drosophila in March 1913 in the lab of Thomas Hunt Morgan.

Thomas Hunt Morgan

T. H. MorganThomas H. MorganT.H. Morgan
Notch was discovered in a mutant Drosophila in March 1913 in the lab of Thomas Hunt Morgan.

Gene

genesnumber of genesgene sequence
The most frequently observed phenotype in Notch mutant flies is the appearance of a concave serration at the most distal end of the wings, for which the gene is named, accompanied by the absence of marginal bristles.

Sex linkage

X-linkedsex-linkedX-linked trait
This mutant was found to be a sex-linked dominant on the X chromosome that could only be observed in heterozygous females as it was lethal in males and homozygous females.

X chromosome

XX-chromosomechromosome X
This mutant was found to be a sex-linked dominant on the X chromosome that could only be observed in heterozygous females as it was lethal in males and homozygous females.

Allele

allelesallelicmultiple alleles
The first Notch allele was established in 1917 by C.W. Metz and C.B. Bridges.

Embryonic development

embryogenesisdevelopmentembryo development
In the late 1930s, studies of fly embryogenesis done by Donald F. Poulson provided the first indication of Notch's role in development.

Germ layer

germ layersmesodermectoderm
Notch-8 mutant males exhibited a lack of the inner germ layers, the endoderm and mesoderm, that resulted in failure to undergo later morphogenesis embryonic lethality.

Endoderm

endodermalEntodermdefinitive endoderm
Notch-8 mutant males exhibited a lack of the inner germ layers, the endoderm and mesoderm, that resulted in failure to undergo later morphogenesis embryonic lethality.

Mesoderm

mesodermalmiddle cell layerparietal layer
Notch-8 mutant males exhibited a lack of the inner germ layers, the endoderm and mesoderm, that resulted in failure to undergo later morphogenesis embryonic lethality.

Morphogenesis

developmentmorphogeneticmorphogenic
Notch-8 mutant males exhibited a lack of the inner germ layers, the endoderm and mesoderm, that resulted in failure to undergo later morphogenesis embryonic lethality.

Neurogenesis

neurogenicneural stem cellneural stem cells
Later studies in early Drosophila neurogenesis provided some of the first indications of Notch's roll in cell-cell signaling, as the nervous system in Notch mutants was developed by sacrificing hypodermal cells.