PLCG2

PLCγ2phosholipase Cγ2Phospholipase C gamma 2PLC-γ
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 is an enzyme that in humans is encoded by the PLCG2 gene.wikipedia
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LYN

Lyn (Src family kinase)p56lyn
LYN activation triggers a cascade of signaling events mediated by Lyn phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the receptor proteins, and subsequent recruitment and activation of other kinases including Syk, phosholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase.

GAB2

Grb2-associated-binding protein 2
An activated complex of GAB2, SHC, and SHP2 is required for binding of Phospholipase C gamma 2 (PLCG2) through its SH2 domain, which activates PIP3.

Enzyme

enzymologyenzymesenzymatic
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 is an enzyme that in humans is encoded by the PLCG2 gene.

Gene

genesnumber of genesgene sequence
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 is an enzyme that in humans is encoded by the PLCG2 gene.

SHC1

ShcSrc homology domain-containing transforming protein 1

PLAID syndrome

The name is an acronym of "PLCG2-associated antibody deficiency and immune dysregulation".

Phospholipase C

PLCIP3/DAG pathwayphospholipase C (PLC)

Platelet

plateletsplatelet aggregationplatelet count
GPVI is associated with the Fc receptor gamma chain and leads via the activation of a tyrosine kinase cascade finally to the activation of PLC-gamma2 PLCG2 and more calcium release.

Fibroblast growth factor receptor 1

FGFR1CD331FGF receptor 1
Activation of the gamma isoforms of phospholipase C (PLCγ) (see PLCG1 and PLCG2 illustrates one mechanism by which FGFR1 activates cell stimulating pathways.

C2 domain

C2 domainsC2 type domainsC2-like
PLCE1; PLCG1; PLCG2; PLCH1; PLCH2; PLCL1; PLCL2; PLCZ1;

NF-κB

NF-kBNF-kappaBNFκB
ZAP70 is then recruited to the phosphorylated ITAMs and helps recruit LAT and PLC-γ, which causes activation of PKC.

B-cell linker

BLNK
The acidic region of BLNK contains several inducibly phosphorylated tyrosine residues, at least five in humans, that mediate protein-protein interactions between BLNK and PLCγ2, Btk, Vav, and Nck.

Phosphoinositide phospholipase C

phospholipase CPLC-γPLCγ
PLCG1; PLCG2; PLCH1; PLCH2; PLCL1; PLCL2; PLCZ1