PTPN6

SHP-1SHP1HP-1
Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene.wikipedia
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SH2 domain

SH2ShcSrc homology 2
N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates.

LYN

Lyn (Src family kinase)p56lyn
This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling, (e.g., the LYN-CD22-SHP-1 pathway).
Their ITIM phosphorylation subsequently leads to recruitment and activation of phosphatases such as SHIP-1 and SHP-1, which further downmodulate signaling pathways, attenuate cell activation and can mediate tolerance.

Protein tyrosine phosphatase

tyrosine phosphataseprotein tyrosine phosphatasesPTP
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family.
The expression of several PTPS is restricted to hematopoietic cells, for example, LYP, SHP1, CD45, and HePTP.

CD22

antigens, cd22Immune responseSiglec-2
This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling, (e.g., the LYN-CD22-SHP-1 pathway).
CD22 has been shown to interact with Grb2, PTPN6, LYN, SHC1 and INPP5D.

CTNND1

p120-cateninp120 cateninp120catenin

LILRB4

CD85K
LILRB4 has been shown to interact with PTPN6 and INPP5D (SHIP-1).

Homeobox A10

HOXA10
Homeobox A10 has been shown to interact with PTPN6.

FCRL3

LILRB2

Lck

lymphocyte specific protein tyrosine kinase p56(lck)lymphocyte-specific protein tyrosine kinase
Lck is also inhibited by SHP-1 dephosphorylation on tyrosine 394.

LAIR1

CD305
LAIR1 has been shown to interact with PTPN11 and PTPN6.

PTK2B

Pyk2Proline-rich tyrosine kinase (Pyk2, CADTK, PTK2beta)PTK2B/RAFTK

Signal-regulatory protein alpha

SIRPASIRPαCD172A
SIRP α has been shown to bind also phosphatase SHP1, adaptor protein SCAP2 and FYN-binding protein.

Tyrosine kinase 2

TYK2TYK
Tyrosine kinase 2 has been shown to interact with FYN, PTPN6, IFNAR1, Ku80 and GNB2L1.

Enzyme

enzymologyenzymesenzymatic
Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene.

Gene

genesnumber of genesgene sequence
Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene.

N-terminus

N-terminalN terminusN-
N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates.