Parke-Davis

Parke, Davis & CoParke, Davis & Co.Hervey Coke ParkeParke, Davis & CompanyParke-Davis & CoParke-Davis & Co.Parke-Davis pharmaceutical companyParke-Davis Research LaboratoriesParke-Davis v. Mulford
Parke-Davis is a subsidiary of the pharmaceutical company Pfizer.wikipedia
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Warner–Lambert

Warner-LambertWarner LambertWarner-Lambert Company
Warner-Lambert acquired Parke-Davis in 1970, which in turn was acquired by Pfizer in 2000.
In 1976, Warner–Lambert took over Parke-Davis, which was founded in Detroit in 1866, by Hervey Parke and George Davis.

Franklin v. Parke-Davis

In the case of Franklin v. Parke-Davis (2002), the company was accused of illegal marketing practices, including the promotion of off-label uses of its anticonvulsant medication Neurontin.
Franklin v. Parke-Davis is a lawsuit filed in 1996 against Parke-Davis, a division of Warner-Lambert Company, and eventually against Pfizer (which bought Warner-Lambert in 2000) under the qui tam provisions of the False Claims Act.

Pfizer

Pfizer Inc.Pfizer, Inc.Pfizer Inc
Warner-Lambert acquired Parke-Davis in 1970, which in turn was acquired by Pfizer in 2000. Parke-Davis is a subsidiary of the pharmaceutical company Pfizer.

Riverwalk Hotel Detroit

Parke-Davis Research LaboratoryRiverwalk HotelRobert's Riverwalk Hotel
The Parke-Davis Research Laboratory is a National Historic Landmark; the surrounding Parke-Davis and Company Pharmaceutical Company Plant is on the National Register of Historic Places.
Parke-Davis moved its facilities to this location along the Detroit River in the 1870s to take advantage of the transportation provided by the river and nearby rail lines.

Gabapentin

NeurontinFranklin v. Parke-DavisGabapentin ER
In the case of Franklin v. Parke-Davis (2002), the company was accused of illegal marketing practices, including the promotion of off-label uses of its anticonvulsant medication Neurontin.
During the 1990s, Parke-Davis, a subsidiary of Pfizer, began using a number of illegal techniques to encourage physicians in the United States to use gabapentin for unapproved uses.

River Place

Parke-DavisParke-Davis Laboratoriescomplex
The Parke-Davis Research Laboratory is a National Historic Landmark; the surrounding Parke-Davis and Company Pharmaceutical Company Plant is on the National Register of Historic Places.
In the 1870s, Parke-Davis moved to the riverfront property this complex now occupies.

Rhamnus purshiana

cascaracascara buckthornFrangula purshiana
The company produced an herbal laxative drug Cascara found from Native Americans in the Pacific Northwest.
By 1877 the U.S. pharmaceutical company Parke-Davis was producing cascara preparations, and soon afterwards cascara products were being exported overseas to European markets.

Robert Thom (illustrator)

Robert Thom
Parke-Davis commissioned Detroit illustrator Robert Thom to produce 40 illustrations for the series, “A History of Pharmacy in Pictures.” Each print came with a history article that explained the depicted scene and its place in history.
He is perhaps best known for his series of 40 paintings depicting the history of pharmacy, and his series of 45 paintings depicting the history of medicine, both commissioned by Parke-Davis.

Coley's toxins

Coley's toxinColey VaccineColey's Fluid
Also, Parke-Davis distributed Coley's toxins, the first cancer vaccine, which was developed by William Coley to treat osteosarcoma.
From 1923 on, Parke-Davis was the only source of Coley's Toxins in the United States.

Takamine Jōkichi

Jōkichi TakamineJokichi TakamineDr. Jokichi Takamine
One of Parke-Davis' early products was an amylase isolated from Aspergillus oryzae by Dr. Jōkichi Takamine.
He later emigrated to the United States and established his own research laboratory in New York City but licensed the exclusive production rights for Takadiastase to one of the largest US pharmaceutical companies, Parke-Davis.

Aleister Crowley

CrowleyCrowley, Aleister Aleister Crowley: The Beast 666
In October 1915, Aleister Crowley, author of Diary of a Drug Fiend and The Confessions of Aleister Crowley, stopped by Parke-Davis in Detroit, where, according to Crowley, the cooperation was complete.
In Detroit he experimented with Peyote at Parke-Davis, then visited Seattle, San Francisco, Santa Cruz, Los Angeles, San Diego, Tijuana, and the Grand Canyon, before returning to New York.

Pharmaceutical industry

pharmaceutical companypharmaceuticalpharmaceutical companies
Parke-Davis is a subsidiary of the pharmaceutical company Pfizer. It was once the world's largest pharmaceutical company and is credited with building the first modern pharmaceutical laboratory and developing the first systematic methods of performing clinical trials of new medications.
Industrial chemist Jōkichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke-Davis.

Cocaine

cokecocaine traffickingcrack
Like Bayer with heroin; before the criminalization of cocaine, the drug was sold by Parke-Davis in various forms, including cigarettes, powder, and even a cocaine mixture that could be injected directly into the user’s veins with the included needle.
In 1885 the U.S. manufacturer Parke-Davis sold cocaine in various forms, including cigarettes, powder, and even a cocaine mixture that could be injected directly into the user's veins with the included needle.

Troglitazone

RezulinPrelay
In partnership with the Japanese firm Daiichi Sankyo Co. and the British firm Glaxo Wellcome, Parke-Davis developed and marketed the anti-diabetic drug Rezulin (troglitazone) in the late 1990s.
In the United States, it was introduced and manufactured by Parke-Davis in the late 1990s, but turned out to be associated with an idiosyncratic reaction leading to drug-induced hepatitis.

Ketamine

K-holeSpecial KCalypsol
It also developed Ketalar (ketamine hydrochloride), a general anesthetic and dissociative drug, in 1962.
Ketamine was first synthesized in 1962 by Calvin L. Stevens, a professor of Chemistry at Wayne State University and a Parke-Davis consultant conducting research on alpha-hydroxyimine rearrangements.

Phencyclidine

PCPangel dustphenylcyclidine
Parke-Davis also was the original manufacturer and patent holder of phencyclidine (PCP) which is currently listed as a Schedule II drug in the United States.
PCP was actually discovered by Victor Maddox, a chemist at Parke-Davis in Michigan, while investigating synthetic analgesic agents.

Combined oral contraceptive pill

birth control pillthe pillbirth control pills
Other products popularized by the company included anti-infectives and brands of combined oral contraceptive pills.
Unable to interest his research sponsor Parke-Davis in the commercial potential of synthesizing progesterone from Mexican yams, Marker left Penn State and in 1944 co-founded Syntex with two partners in Mexico City.

Phenytoin

Dilantindiphenylhydantoindephenylhydantoin
Parke-Davis marketed the first widely available epilepsy treatment, Dilantin, which was approved in 1939, although it discovered neither the compound nor the application on its own.
This was partially because Parke-Davis was reluctant to invest in a drug nearing the end of its patent life, and partially due to mixed results from various studies.

Chloramphenicol

Chloromycetin8chloramphenicolAmphicol
Parke-Davis also produced the broad-spectrum antibiotic chloramphenicol, which was a blockbuster product before the discovery of its association with aplastic anemia.
Chloramphenicol was first isolated from Streptomyces venezuelae in 1947 and in 1949 a team of scientists at Parke-Davis including Mildred Rebstock published their identification of the chemical structure and their synthesis, making it the first antibiotic to be made instead of extracted from a micro-organism.

Subsidiary

subsidiarieswholly owned subsidiarysubsidiary company
Parke-Davis is a subsidiary of the pharmaceutical company Pfizer.

Detroit

Detroit, MichiganDetroit, MICity of Detroit
Parke, Davis and Company was founded in Detroit, Michigan by Dr. Samuel P. Duffield, a physician and pharmacist.

Michigan

MIState of MichiganMich.
Parke, Davis and Company was founded in Detroit, Michigan by Dr. Samuel P. Duffield, a physician and pharmacist.

Clinical trial

clinical trialsclinical studiesclinical study
It was once the world's largest pharmaceutical company and is credited with building the first modern pharmaceutical laboratory and developing the first systematic methods of performing clinical trials of new medications.

National Historic Landmark

National Historic Landmark DistrictNational Historic LandmarksNational Historical Landmark
The Parke-Davis Research Laboratory is a National Historic Landmark; the surrounding Parke-Davis and Company Pharmaceutical Company Plant is on the National Register of Historic Places.

National Register of Historic Places

National RegisterMultiple Property SubmissionNational Register of Historical Places
The Parke-Davis Research Laboratory is a National Historic Landmark; the surrounding Parke-Davis and Company Pharmaceutical Company Plant is on the National Register of Historic Places.