Paroxetine

PaxilSeroxatparoxetine hydrochlorideDiscontinuation syndrome (withdrawal)drugOxetinetrans''-4-(4-Fluorophenyl)-3-[(3,4-methylenedioxy)phenoxy]methylpiperidine
Paroxetine, sold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.wikipedia
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Antidepressant

antidepressantsanti-depressantanti-depressants
Paroxetine, sold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
Paroxetine was the first drug to be FDA approved for this disorder, it's efficacy is considered beneficial although not everyone respond favorably to the drug.

Selective serotonin reuptake inhibitor

SSRIselective serotonin reuptake inhibitorsSSRIs
Paroxetine, sold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
Paroxetine was the first drug to be approved for social anxiety disorder and it is considered effective for this disorder, sertraline and fluvoxamine were later approved for it too, escitalopram and citalopram are used off label with acceptable efficacy, while fluoxetine is not considered to be effective for this disorder.

Social anxiety disorder

social phobiaAnthropophobiasociophobia
It is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder.
Medications such as SSRIs are effective for social phobia, especially paroxetine.

Study 329

The United States Department of Justice fined GlaxoSmithKline $3 billion in 2012, for withholding data, unlawfully promoting use in those under 18, and preparing an article that misleadingly reported the effects of paroxetine in adolescent with depression following its clinical trial study 329.
Study 329 was a clinical trial conducted in North America from 1994 to 1998 to study the efficacy of paroxetine, an SSRI anti-depressant, in treating 12- to 18-year-olds diagnosed with major depressive disorder.

Generalized anxiety disorder

general anxiety disordergeneralized anxietyanxiety
It is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder.
FDA approved SSRIs used for this purpose include escitalopram and paroxetine.

Antidepressant discontinuation syndrome

withdrawal syndromediscontinuation syndromeSSRI discontinuation syndrome
While the rate of side effects appear similar compared to other SSRIs and SNRIs, antidepressant discontinuation syndromes may occur more often.
Paroxetine and venlafaxine seem to be particularly difficult to discontinue, and prolonged withdrawal syndrome (post-acute-withdrawal syndrome, or PAWS) lasting over 18 months has been reported with paroxetine.

Major depressive disorder

depressionclinical depressionmajor depression
It is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder.
A review commissioned by the National Institute for Health and Care Excellence (UK) concluded that there is strong evidence that selective serotonin reuptake inhibitors (SSRIs), such as escitalopram, paroxetine, and sertraline, have greater efficacy than placebo on achieving a 50% reduction in depression scores in moderate and severe major depression, and that there is some evidence for a similar effect in mild depression.

Venlafaxine

EffexorEffexor XRVenlafaxin
Comparative efficacy of paroxetine is equivalent to that of clomipramine and venlafaxine.
A comparative meta-analysis of 21 major antidepressants found that venlafaxine, agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, and vortioxetine were more effective than other antidepressants although the quality of many comparisons was assessed as low or very low.

Premature ejaculation

ejaculatio praecoxprematurelyejaculates prematurely
It has also been used in the treatment of premature ejaculation and hot flashes due to menopause.
These include selective serotonin reuptake inhibitors (SSRIs), such as paroxetine or dapoxetine, as well as clomipramine.

Premenstrual dysphoric disorder

PMDDdysphoric disorderpremenstrual dysphoric disorder (PMDD)
It is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder.
The U.S. Food and Drug Administration (FDA) has approved four SSRIs for the treatment of PMDD: Fluoxetine (available as generic or as Prozac or Sarafem), sertraline (Zoloft), paroxetine (Paxil), and escitalopram oxalate (Lexapro).

Menopause

postmenopausalmenopausalpremenopausal
It has also been used in the treatment of premature ejaculation and hot flashes due to menopause.
Low dose paroxetine is the only non-hormonal medication that was FDA-approved to treat moderate-to-severe vasomotor symptoms associated with menopause as of 2016.

Fluoxetine

ProzacProzakSarafem
Another recommendation is to temporarily switch to fluoxetine, which has a longer half-life and thus decreases the severity of discontinuation syndrome. Along with the other SSRIs, sertraline and fluoxetine, paroxetine is considered a low-risk drug in cases of overdose.
A 2009 meta-analysis by Fournier which evaluated patient-level data from six trials of the SSRI paroxetine and the non-SSRI antidepressant imipramine has been further cited as evidence that antidepressants exhibit minimal efficacy in mild to moderate depression.

GlaxoSmithKline

GlaxoSmithKline BeechamGSK
Paroxetine was approved for medical use in the United States in 1992 and initially sold by GlaxoSmithKline.
Medicines historically discovered or developed at GSK and its legacy companies and now sold as generics include amoxicillin and amoxicillin-clavulanate, ticarcillin-clavulanate, mupirocin, and ceftazidime for bacterial infections, zidovudine for HIV infection, valacyclovir for herpes virus infections, albendazole for parasitic infections, sumatriptan for migraine, lamotrigine for epilepsy, bupropion and paroxetine for major depressive disorder, cimetidine and ranitidine for gastroesophageal reflux disorder, mercaptopurine and thioguanine for the treatment of leukemia, allopurinol for gout, pyrimethamine for malaria, and the antibacterial trimethoprim.

Sertraline

ZoloftLustralSertraline Hydrochloride
Along with the other SSRIs, sertraline and fluoxetine, paroxetine is considered a low-risk drug in cases of overdose.
It is unclear if sertraline is any different from another SSRI, paroxetine, for depression; though escitalopram may have some benefits over sertraline.

Posttraumatic stress disorder

post-traumatic stress disorderPTSDpost traumatic stress disorder
It is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder.
Evidence provides support for a small or modest improvement with sertraline, fluoxetine, paroxetine, and venlafaxine.

Obsessive–compulsive disorder

obsessive-compulsive disorderobsessive compulsive disorderOCD
It is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder.
Administration of opiate treatment may be contraindicated in individuals concurrently taking CYP2D6 inhibitors such as fluoxetine and paroxetine.

Clomipramine

Anafranilchlorimipramineclomipramine hydrochloride
Comparative efficacy of paroxetine is equivalent to that of clomipramine and venlafaxine.
Other studies have found 83% SERT occupancy with 20 mg/day paroxetine and 77% SERT occupancy with 20 mg/day citalopram.

CYP2D6

2D6cytochrome P450 2D6cytochrome p-450 cyp2d6
Paroxetine is a mechanism-based inhibitor of CYP2D6.

Paresthesia

paraesthesiatinglingparesthesias
Paroxetine shares many of the common adverse effects of SSRIs, including (with the corresponding rates seen in people treated with placebo in parentheses): nausea 26% (9%), diarrhea 12% (8%), constipation 14% (9%), dry mouth 18% (12%), somnolence 23% (9%), insomnia 13% (6%), headache 18% (17%), hypomania 1% (0.3%), blurred vision 4%(1%), loss of appetite 6% (2%), nervousness 5% (3%), paraesthesia 4% (2%), dizziness 13% (6%), asthenia (weakness; 15% (6%)), tremor 8% (2%), sweating 11% (2%), and sexual dysfunction (≥10% incidence).

5-HT2C receptor

5-HT 2C 5-HT 2C receptor5HT 2C
Activation of 5-HT 2C by serotonin is responsible for many of the negative side effects of SSRI and SNRI medications, such as sertraline, paroxetine, venlafaxine, and others.

Adrenergic receptor

adrenergic receptorsβadrenergic
Since GRK2 regulates the activity of the beta adrenergic receptor, which becomes desensitized in cases of heart failure, paroxetine (or a paroxetine derivative) could be used as a heart failure treatment in the future.

Dysthymia

chronic depressiondysthymic disorderdysthymic
Although the evidence is conflicting, paroxetine may be effective for the treatment of dysthymia, a chronic disorder involving depressive symptoms for most days of the year.
The most commonly prescribed antidepressants/SSRIs for dysthymia are escitalopram, citalopram, sertraline, fluoxetine, paroxetine, and fluvoxamine.

Diabetic neuropathy

neuropathydiabetic neuropathiesdiabetic peripheral neuropathy
Benefits of paroxetine prescription for diabetic neuropathy or chronic tension headache are uncertain.
SSRIs include fluoxetine, paroxetine, sertraline, and citalopram have been found to be no more efficacious than placebo in several controlled trials and therefore are not recommended to treat painful diabetic neuropathy.