Phosphinothricin acetyltransferase

phosphinothricin-N- acetyl-transferase
Phosphinothricin acetyltransferase (, PAT, PPT acetyltransferase, Pt-N-acetyltransferase, ac-Pt) is an enzyme with systematic name acetyl-CoA:phosphinothricin N-acetyltransferase.wikipedia
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Glufosinate

phosphinothricinglufosinate ammonium
The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2.
In the late 1980s scientists discovered enzymes in these Streptomyces species that selectively inactivate free phosphinothricin; the gene encoding the enzyme that was isolated from Streptomyces hygroscopicus was called the "bialaphos resistance" or "bar" gene, and the gene encoding the enzyme in Streptomyces viridochromeogenes was called "phosphinothricin acetyltransferase" or "pat".

Enzyme

enzymologyenzymesenzymatic
Phosphinothricin acetyltransferase (, PAT, PPT acetyltransferase, Pt-N-acetyltransferase, ac-Pt) is an enzyme with systematic name acetyl-CoA:phosphinothricin N-acetyltransferase.

List of enzymes

systematic nameclassified
Phosphinothricin acetyltransferase (, PAT, PPT acetyltransferase, Pt-N-acetyltransferase, ac-Pt) is an enzyme with systematic name acetyl-CoA:phosphinothricin N-acetyltransferase.

Catalysis

catalyzescatalysescatalyst
This enzyme catalyses the following chemical reaction

Chemical reaction

reactionchemical reactionsreactions
This enzyme catalyses the following chemical reaction

Herbicide

herbicidesherbicidalweed killer
The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2.

Glutamine synthetase

glutamate-ammonia ligaseGLULGS
The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2.

DMH-11 Mustard

The insertion of the third gene Bar, enables DMH - 11 to produce phosphinothricin-N- acetyl-transferase, the enzyme responsible for Glufosinate resistance.

PAT

Phosphinothricin acetyltransferase, an enzyme

Transfer DNA

T-DNA
Examples of selection markers include neomycin phosphotransferase, hygromycin B phosphotransferase (which both phosphorylate antibiotics) and phosphinothricin acetyltransferase (which acetylates and deactivates phosphinothricin, a potent inhibitor of glutamine synthetase) or a herbicide formulations such as Basta or Bialophos.