Polyarteritis nodosa

periarteritis nodosaPolyarteritisPANKussmaul diseaseKussmaul-Maier diseasepanarteritis nodosa
Polyarteritis nodosa (PAN), is a systemic necrotizing inflammation of blood vessels (vasculitis) affecting medium-sized muscular arteries, typically involving the arteries of the kidneys and other internal organs but generally sparing the lungs' circulation.wikipedia
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Systemic disease

systemicsystemic infectionmultisystem disease
Polyarteritis nodosa (PAN), is a systemic necrotizing inflammation of blood vessels (vasculitis) affecting medium-sized muscular arteries, typically involving the arteries of the kidneys and other internal organs but generally sparing the lungs' circulation.

Vasculitis

vasculitidesvasculiticvasculitis, central nervous system
Polyarteritis nodosa (PAN), is a systemic necrotizing inflammation of blood vessels (vasculitis) affecting medium-sized muscular arteries, typically involving the arteries of the kidneys and other internal organs but generally sparing the lungs' circulation.
Takayasu's arteritis, polyarteritis nodosa and giant cell arteritis mainly involve arteries and are thus sometimes classed specifically under arteritis.

Hepatitis B

Bchronic hepatitis Bhepatitis B virus
PAN is sometimes associated with infection by the hepatitis B or hepatitis C virus.
Symptoms outside of the liver are present in 1–10% of HBV-infected people and include serum-sickness–like syndrome, acute necrotizing vasculitis (polyarteritis nodosa), membranous glomerulonephritis, and papular acrodermatitis of childhood (Gianotti–Crosti syndrome).

Livedo reticularis

lacy skin pigmentation
Skin manifestations of PAN include palpable purpura and livedo reticularis in some individuals.

Bigger Than Life

The 1956 film Bigger Than Life featured the protagonist being diagnosed with polyarteritis nodosa.
Schoolteacher and family man Ed Avery (James Mason), who has been suffering bouts of severe pain and even blackouts, is hospitalized with what is diagnosed as polyarteritis nodosa, a rare inflammation of the arteries.

Hairy cell leukemia

Hairy cell leukaemialeukemia, hairy cellHairy-cell leukemia
PAN has also been associated with underlying hairy cell leukemia.
Polyarteritis nodosa has been associated with underlying hairy cell leukemia in certain cases.

Arteritis

Coronary arteritisinflammation of arteriesinflammatory arterial disorders

Rudolf Robert Maier

The medical eponyms (Kussmaul disease or Kussmaul-Maier disease) reflect the seminal description of the disease in the medical literature by Adolph Kussmaul and Rudolf Robert Maier.
With Adolf Kussmaul (1822–1902), Maier provided the first comprehensive description of periarteritis nodosa, a condition sometimes referred to as "Kussmaul-Maier disease".

Microscopic polyangiitis

Polyarteritis nodosa rarely affects the blood vessels of the lungs and this feature can help to differentiate it from other vasculitides, which may have similar signs and symptoms (e.g., granulomatosis with polyangiitis or microscopic polyangiitis).

Adolf Kussmaul

Adolph KussmaulKussmaul
The medical eponyms (Kussmaul disease or Kussmaul-Maier disease) reflect the seminal description of the disease in the medical literature by Adolph Kussmaul and Rudolf Robert Maier.

Necrosis

necroticnecrotizingnecrotic tissue
Polyarteritis nodosa (PAN), is a systemic necrotizing inflammation of blood vessels (vasculitis) affecting medium-sized muscular arteries, typically involving the arteries of the kidneys and other internal organs but generally sparing the lungs' circulation.

Artery

arteriesarterialarterial system
Polyarteritis nodosa (PAN), is a systemic necrotizing inflammation of blood vessels (vasculitis) affecting medium-sized muscular arteries, typically involving the arteries of the kidneys and other internal organs but generally sparing the lungs' circulation.

Renal artery

renal arteriesrenalarteries of the kidneys
Polyarteritis nodosa (PAN), is a systemic necrotizing inflammation of blood vessels (vasculitis) affecting medium-sized muscular arteries, typically involving the arteries of the kidneys and other internal organs but generally sparing the lungs' circulation.

Rosary

rosariesrosary beadsHoly Rosary
In polyarteritis nodosa, small aneurysms are strung like the beads of a rosary, therefore making "rosary sign" an important diagnostic feature of the vasculitis.

Hepatitis C

Chepatitis-CHCV
PAN is sometimes associated with infection by the hepatitis B or hepatitis C virus.

Kidney failure

renal failurekidney problemsrenal impairment
Death is often a consequence of kidney failure, myocardial infarction, or stroke.

Myocardial infarction

heart attackheart attacksacute myocardial infarction
Death is often a consequence of kidney failure, myocardial infarction, or stroke.

Stroke

ischemic strokestrokescerebrovascular accident
Death is often a consequence of kidney failure, myocardial infarction, or stroke.

Fever

pyrexiafebrileague
Constitutional symptoms are seen in up to 90% of affected individuals and include fever, fatigue, weakness, loss of appetite, and unintentional weight loss.

Fatigue

exhaustionOverexertiontiredness
Constitutional symptoms are seen in up to 90% of affected individuals and include fever, fatigue, weakness, loss of appetite, and unintentional weight loss.

Weakness

astheniamuscular weaknessphysical weakness
Constitutional symptoms are seen in up to 90% of affected individuals and include fever, fatigue, weakness, loss of appetite, and unintentional weight loss.

Anorexia (symptom)

anorexialoss of appetitedecreased appetite
Constitutional symptoms are seen in up to 90% of affected individuals and include fever, fatigue, weakness, loss of appetite, and unintentional weight loss.

Peripheral neuropathy

neuropathyneuropathiesneuropathic
Peripheral nerves are often affected and this most commonly presents as mononeuritis multiplex, which is the most common neurologic sign of PAN.