Pramipexole

MirapexPramipexol
Pramipexole, sold under the brand Mirapex among others, is medication used to treat Parkinson's disease (PD) and restless legs syndrome (RLS).wikipedia
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Restless legs syndrome

restless leg syndromerestless legsrestless legs syndrome (RLS)
Pramipexole, sold under the brand Mirapex among others, is medication used to treat Parkinson's disease (PD) and restless legs syndrome (RLS).
Medications used include levodopa or a dopamine agonist such as pramipexole.

Dopamine agonist

dopamine agonistsdopamine receptor agonistdopamine
It is a dopamine agonist of the non-ergoline class.
Types of ergoline agonists are cabergoline and bromocriptine and examples of non-ergoline agonists are pramipexole, ropinirole and rotigotine.

Parkinson's disease

ParkinsonParkinson’s diseaseParkinson disease
Pramipexole, sold under the brand Mirapex among others, is medication used to treat Parkinson's disease (PD) and restless legs syndrome (RLS).
Dopamine agonists include bromocriptine, pergolide, pramipexole, ropinirole, piribedil, cabergoline, apomorphine and lisuride.

Ropinirole

RequipAdartrelropinerole
Several unusual adverse effects of pramipexole (and related D 3 -preferring dopamine agonist medications such as ropinirole) may include compulsive gambling, punding, hypersexuality, and overeating, even in patients without any prior history of these behaviours.
Unusual side effects specific to D 3 agonists such as ropinirole and pramipexole can include hypersexuality, punding and compulsive gambling, even in patients without a history of these behaviours.

Overeating

excessive eatingdesireOver eating
Several unusual adverse effects of pramipexole (and related D 3 -preferring dopamine agonist medications such as ropinirole) may include compulsive gambling, punding, hypersexuality, and overeating, even in patients without any prior history of these behaviours.
In some instances, overeating has been linked to the use of medications known as dopamine agonists, such as pramipexole.

Dopaminergic

dopaminergic drugsdopaminergic neuronsDA
The substantia nigra has a high quantity of dopaminergic neurons, which are nerve cells that release the neurotransmitter known as dopamine.
* Dopamine receptor agonists such as apomorphine, bromocriptine, cabergoline, dihydrexidine (LS-186,899), dopamine, fenoldopam, piribedil, lisuride, pergolide, pramipexole, ropinirole, and rotigotine, are used in the treatment of Parkinson's disease and to treat depression and anxiety.

Fibromyalgia

fibrositisFibromyalgia syndromemuscular rheumatism
It is also being investigated for the treatment of clinical depression and fibromyalgia.
Dopamine agonists (e.g. pramipexole and ropinirole) resulted in some improvement in a minority of people, but side effects, including the onset of impulse control disorders like compulsive gambling and shopping, might be a concern for some people.

L-DOPA

levodopa L -DOPADOPA
In PD it may be used alone or together with levodopa.

Gambling

gamblerbettinggaming
Serious side effects may include an urge to gamble or have sex, heart failure, and low blood pressure.

Heart failure

congestive heart failurecardiac failurechronic heart failure
Serious side effects may include an urge to gamble or have sex, heart failure, and low blood pressure.

Hypotension

low blood pressurehypotensivelow
Serious side effects may include an urge to gamble or have sex, heart failure, and low blood pressure.

Pregnancy

pregnantfirst trimesterpregnant women
Use in pregnancy and breastfeeding is of unclear safety.

Breastfeeding

breast feedingbreastfeedbreast-feeding
Use in pregnancy and breastfeeding is of unclear safety.

Ergoline

ergot alkaloidergopeptineergolines
It is a dopamine agonist of the non-ergoline class.

Generic drug

generic medicationgenericgeneric drugs
It is available as a generic medication.

National Health Service

NHSNational Health Service (NHS)National Health Services
A month supply in the United Kingdom costs the NHS about £8.40 as of 2019.

Side effect

side effectsside-effectsside-effect
Common side effects of pramipexole may include:

Problem gambling

gambling addictioncompulsive gamblingpathological gambling
Several unusual adverse effects of pramipexole (and related D 3 -preferring dopamine agonist medications such as ropinirole) may include compulsive gambling, punding, hypersexuality, and overeating, even in patients without any prior history of these behaviours.

Punding

Several unusual adverse effects of pramipexole (and related D 3 -preferring dopamine agonist medications such as ropinirole) may include compulsive gambling, punding, hypersexuality, and overeating, even in patients without any prior history of these behaviours.

Hypersexuality

nymphomaniachypersexualsatyriasis
Several unusual adverse effects of pramipexole (and related D 3 -preferring dopamine agonist medications such as ropinirole) may include compulsive gambling, punding, hypersexuality, and overeating, even in patients without any prior history of these behaviours.

Peripheral edema

peripheral oedemaleg swellingPeripheral

Hyperalgesia

hyperalgesicanti-hyperalgesicantihyperalgesic