Pregabalin

Lyrica
Pregabalin, marketed under the brand name Lyrica among others, is a medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, and generalized anxiety disorder.wikipedia
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Generalized anxiety disorder

general anxiety disordergeneralized anxietyanxiety
Pregabalin, marketed under the brand name Lyrica among others, is a medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, and generalized anxiety disorder.
Medications which have been found to be useful include duloxetine, pregabalin, venlafaxine, and escitalopram.

Fibromyalgia

fibrositisFibromyalgia syndromemuscular rheumatism
Pregabalin, marketed under the brand name Lyrica among others, is a medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, and generalized anxiety disorder.
The medications duloxetine, milnacipran or pregabalin may be used.

Gabapentinoid

Gabapentinoids
Pregabalin is a gabapentinoid and acts by inhibiting certain calcium channels.
This site has been referred to as the gabapentin receptor (α 2 δ subunit), as it is the target of the drugs gabapentin and pregabalin.

Sciatica

lumbosacral radiculopathylumbar radiculopathysciatic
Evidence does not support it being useful in sciatica or low back pain.
Many treatments, including corticosteroids, gabapentin, pregabalin, acupuncture, heat or ice, and spinal manipulation, have limited or poor evidence for their use.

Gabapentin

NeurontinFranklin v. Parke-DavisGabapentin ER
It was developed as a successor to gabapentin.
It appears to be as effective as pregabalin for neuropathic pain and costs less.

Venlafaxine

EffexorEffexor XRVenlafaxin
The effects of pregabalin appear after 1 week of use and is similar in effectiveness to lorazepam, alprazolam, and venlafaxine, but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychosomatic anxiety symptoms.
Studies have shown venlafaxine's effectiveness for these conditions, although agents that are marketed for this purpose (like pregabalin or duloxetine) are likely preferred.

Neuropathic pain

neuropathicpaincentral neuropathic pain
Pregabalin, marketed under the brand name Lyrica among others, is a medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, and generalized anxiety disorder. The European Federation of Neurological Societies recommends pregabalin as a first line agent for the treatment of pain associated with diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain.
Favored treatments are certain antidepressants (tricyclic antidepressants and serotonin–norepinephrine reuptake inhibitors), anticonvulsants (pregabalin and gabapentin), and topical lidocaine.

Somnolence

drowsinesssleepinessDrowsy
Common side effects include headache, dizziness, sleepiness, confusion, trouble with memory, poor coordination, dry mouth, problem with vision, and weight gain.

Restless legs syndrome

restless leg syndromerestless legsrestless legs syndrome (RLS)
Pregabalin, marketed under the brand name Lyrica among others, is a medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, and generalized anxiety disorder.

Diabetic neuropathy

neuropathydiabetic neuropathiesdiabetic peripheral neuropathy
The European Federation of Neurological Societies recommends pregabalin as a first line agent for the treatment of pain associated with diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain.
The only three medications approved by the United States' Food and Drug Administration for diabetic peripheral neuropathy (DPN) are the antidepressant duloxetine, the anticonvulsant pregabalin, and the long-acting opioid tapentadol ER.

Migraine

migrainesmigraine headachemigraine headaches
There is no evidence for its use in the prevention of migraines and gabapentin has also been found not to be useful.
Recommendations regarding effectiveness varied however for gabapentin and pregabalin.

Substance dependence

addictiondependencedrug dependence
It appears to have anxiolytic effects similar to benzodiazepines with less risk of dependence.
Some examples are using benzodiazepines for alcohol detoxification, which prevents delirium tremens and complications; using a slow taper of benzodiazepines or a taper of phenobarbital, sometimes including another antiepileptic agent such as gabapentin, pregabalin, or valproate, for withdrawal from barbiturates or benzodiazepines; using drugs such as baclofen to reduce cravings and propensity for relapse amongst addicts to any drug, especially effective in stimulant users, and alcoholics (in which it is nearly as effective as benzodiazepines in preventing complications); using clonidine, an alpha-agonist, and loperamide for opioid detoxification, for first-time users or those who wish to attempt an abstinence-based recovery (90% of opioid users relapse to active addiction within eight months or are multiple relapse patients); or replacing an opioid that is interfering with or destructive to a user's life, such as illicitly-obtained heroin, dilaudid, or oxycodone, with an opioid that can be administered legally, reduces or eliminates drug cravings, and does not produce a high, such as methadone or buprenorphine – opioid replacement therapy – which is the gold standard for treatment of opioid dependence in developed countries, reducing the risk and cost to both user and society more effectively than any other treatment modality (for opioid dependence), and shows the best short-term and long-term gains for the user, with the greatest longevity, least risk of fatality, greatest quality of life, and lowest risk of relapse and legal issues including arrest and incarceration.

Low back pain

lumbagolower back painlower back
Evidence does not support it being useful in sciatica or low back pain.
Although the antiseizure drugs gabapentin, pregabalin, and topiramate are sometimes used for chronic low back pain evidence does not support a benefit.

Anxiolytic

anxiolysisanti-anxietyanxiolytics
It appears to have anxiolytic effects similar to benzodiazepines with less risk of dependence. In accordance, inhibition of α 2 δ-1-containing VDCCs by pregabalin appears to be responsible for its anticonvulsant, analgesic, and anxiolytic effects.
Phenibut is a GABA B receptor agonist, as well as an antagonist at α 2 δ subunit-containing voltage-dependent calcium channels (VDCCs), similarly to gabapentinoids like gabapentin and pregabalin.

Opioid

opioidsopioid-induced constipationopioid analgesic
The manufacturer notes some potential pharmacological interactions with opioids, benzodiazepines, barbiturates, ethanol (alcohol), and other drugs that depress the central nervous system.

Alcohol withdrawal syndrome

alcohol withdrawalwithdrawalalcohol
Evidence of benefit in alcohol withdrawal is poor as of 2016.
Very limited evidence indicates that topiramate or pregabalin may be useful in the treatment of alcohol withdrawal syndrome.

Analgesic

analgesiaanalgesicspainkillers
In accordance, inhibition of α 2 δ-1-containing VDCCs by pregabalin appears to be responsible for its anticonvulsant, analgesic, and anxiolytic effects.
Adjuvant analgesics, also called atypical analgesics, include nefopam, orphenadrine, pregabalin, gabapentin, cyclobenzaprine, hyoscine (scopolamine), and other drugs possessing anticonvulsant, anticholinergic, and/or antispasmodic properties, as well as many other drugs with CNS actions.

Physical dependence

dependencedrug dependencyphysical
Following abrupt or rapid discontinuation of pregabalin, some people reported symptoms suggestive of physical dependence.

Richard Bruce Silverman

Richard Silverman
It was invented by medicinal chemist Richard Bruce Silverman at Northwestern University in Evanston, Illinois.
He is well known for the discovery of pregabalin, which is marketed by Pfizer under the trade name Lyrica.

GABA analogue

derivative
Despite the fact that pregabalin is a GABA analogue, it does not bind to the GABA receptors, does not convert into GABA or another GABA receptor agonist in vivo, and does not directly modulate GABA transport or metabolism.

Voltage-gated calcium channel

voltage-dependent calcium channelvoltage-gated calcium channelsVDCC
Specifically it is a ligand of the auxiliary α 2 δ subunit site of certain voltage-dependent calcium channels (VDCCs), and thereby acts as an inhibitor of α 2 δ subunit-containing VDCCs.
This drug class includes two anticonvulsant drugs, gabapentin (Neurontin) and pregabalin (Lyrica), that also find use in treating chronic neuropathic pain.

CACNA2D1

1α 2 δ-1α 2 δ 1 subunit
There are two drug-binding α 2 δ subunits, α 2 δ-1 and α 2 δ-2, and pregabalin shows similar affinity for (and hence lack of selectivity between) these two sites.
alpha2/delta proteins are believed to be the molecular target of the gabapentinoids gabapentin and pregabalin, which are used to treat epilepsy and neuropathic pain.

Pfizer

Pfizer Inc.Pfizer, Inc.Pfizer Inc
In November 2018 the Supreme Court of the United Kingdom ruled that Pfizer's second patent on the drug, for treatment of pain, was invalid because there was a lack of evidence for the conditions it covered – central and peripheral neuropathic pain.
Its products include the blockbuster drug Lipitor (atorvastatin), used to lower LDL blood cholesterol; Lyrica (pregabalin) for neuropathic pain and fibromyalgia; Diflucan (fluconazole), an oral antifungal medication; Zithromax (azithromycin), an antibiotic; Viagra (sildenafil) for erectile dysfunction; and Celebrex (also Celebra, celecoxib), an anti-inflammatory drug.

Northwestern University

NorthwesternNorth Western UniversityIntegrated science program
It was invented by medicinal chemist Richard Bruce Silverman at Northwestern University in Evanston, Illinois.
In 2007, the university sold its royalty interest in the pain relief drug Lyrica for $700 million, a drug developed at Northwestern by Richard Bruce Silverman (for whom Silverman Hall was named), who is the John Evans Professor of Chemistry.

Postherpetic neuralgia

post-herpetic neuralgianeuralgia, postherpeticnerve pain caused by shingles
The European Federation of Neurological Societies recommends pregabalin as a first line agent for the treatment of pain associated with diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain.
Oral anticonvulsant medications such as gabapentin and pregabalin are also approved for treatment of PHN.