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Parkinson's disease

ParkinsonParkinson diseaseParkinson’s disease
PSP may be mistaken for other neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.
They include multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies (DLB).

Dementia

senilesenilitysenile dementia
The condition leads to symptoms including loss of balance, slowing of movemen t, difficulty moving the eyes, and dementia. Later symptoms and signs are dementia (typically including loss of inhibition and ability to organize information), slurring of speech, difficulty swallowing, and difficulty moving the eyes, particularly in the vertical direction.
Progressive supranuclear palsy (PSP) is a form of dementia that is characterized by problems with eye movements.

Degenerative disease

degenerativedegenerative diseasesdegenerative disorder
Progressive supranuclear palsy (PSP), also known as Steele–Richardson–Olszewski syndrome, is a degenerative disease involving the gradual deterioration and death of specific volumes of the brain.
Progressive supranuclear palsy

Pseudobulbar palsy

pseudobulbarpseudobulbar dysarthria
Pseudobulbar palsy
Progressive supranuclear palsy

Frontotemporal dementia

fronto-temporal dementiaFrontotemporal dementia (FTD)Dementia, frontotemporal
Some consider PSP, corticobasal degeneration, and frontotemporal dementia to be variations of the same disease.
They are: behavioral variant of FTD, semantic variant primary progressive aphasia, nonfluent agrammatic variant primary progressive aphasia, corticobasal syndrome, progressive supranuclear palsy, and FTD associated with motor neuron disease.

Corticobasal degeneration

Some consider PSP, corticobasal degeneration, and frontotemporal dementia to be variations of the same disease. Their chemical composition is usually different, however, and is similar to that of tangles seen in corticobasal degeneration.
Clinical diagnosis is difficult, as symptoms of CBgD are often similar to those of other disorders, such as Parkinson's disease (PD), progressive supranuclear palsy (PSP), and dementia with Lewy bodies (DLB).

Hypokinesia

bradykinesiaakinesiarigidity
The condition leads to symptoms including loss of balance, slowing of movemen t, difficulty moving the eyes, and dementia.

Tau protein

tautau proteinsMAPT
The cause of the condition is uncertain but involves accumulation of tau protein within the brain. The neurons display neurofibrillary tangles (NFTs), which are clumps of tau protein, a normal part of a brain cell's internal structural skeleton.
Progressive supranuclear palsy

Eye movement

eye movementsversionmovements of the eye
Later symptoms and signs are dementia (typically including loss of inhibition and ability to organize information), slurring of speech, difficulty swallowing, and difficulty moving the eyes, particularly in the vertical direction.
Progressive supranuclear palsy

Parkinson plus syndrome

atypical parkinsonian syndromeParkinson plus
It is one of a number of diseases collectively referred to as Parkinson plus syndromes.
They include multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD).

Mickey Mouse sign

MRI may show atrophy in the midbrain with preservation of the pons giving a "hummingbird" sign appearance and Mickey Mouse sign
Midbrain of progressive supranuclear palsy (PSP).

Neurofibrillary tangle

neurofibrillary tanglestanglestangle diseases
The neurons display neurofibrillary tangles (NFTs), which are clumps of tau protein, a normal part of a brain cell's internal structural skeleton.
Progressive supranuclear palsy although with straight filament rather than PHF tau

Brain

brain functionmammalian braincerebral
Progressive supranuclear palsy (PSP), also known as Steele–Richardson–Olszewski syndrome, is a degenerative disease involving the gradual deterioration and death of specific volumes of the brain.

Balance disorder

postural instabilitybalancebalance problems
The condition leads to symptoms including loss of balance, slowing of movemen t, difficulty moving the eyes, and dementia.

Amantadine

amantadine hydrochloride
Medications such as levodopa and amantadine may be useful in some cases.

Malé

malemasculine
Males are slightly more likely to be affected than females.

Relaxed pronunciation

slurred speechslurslurring
Later symptoms and signs are dementia (typically including loss of inhibition and ability to organize information), slurring of speech, difficulty swallowing, and difficulty moving the eyes, particularly in the vertical direction.

Eyelid

eyelidspalpebralpalpebra
Some of the other signs are poor eyelid function, contracture of the facial muscles, a backward tilt of the head with stiffening of the neck muscles, sleep disruption, urinary incontinence and constipation.

Contracture

contracturescontractionjoint contractures
Some of the other signs are poor eyelid function, contracture of the facial muscles, a backward tilt of the head with stiffening of the neck muscles, sleep disruption, urinary incontinence and constipation.

Facial muscles

muscles of facial expressionfacial musclemuscle of facial expression
Some of the other signs are poor eyelid function, contracture of the facial muscles, a backward tilt of the head with stiffening of the neck muscles, sleep disruption, urinary incontinence and constipation.

List of skeletal muscles of the human body

neck musclesMuscleHead
Some of the other signs are poor eyelid function, contracture of the facial muscles, a backward tilt of the head with stiffening of the neck muscles, sleep disruption, urinary incontinence and constipation.

Sleep disorder

sleep disorderssleep disturbancesleep disturbances
Some of the other signs are poor eyelid function, contracture of the facial muscles, a backward tilt of the head with stiffening of the neck muscles, sleep disruption, urinary incontinence and constipation.

Urinary incontinence

incontinenceurinaryincontinent
Some of the other signs are poor eyelid function, contracture of the facial muscles, a backward tilt of the head with stiffening of the neck muscles, sleep disruption, urinary incontinence and constipation.

Constipation

constipatedobstipationchronic constipation
Some of the other signs are poor eyelid function, contracture of the facial muscles, a backward tilt of the head with stiffening of the neck muscles, sleep disruption, urinary incontinence and constipation.