Protein precursor

precursorprecursor proteinpropeptideproproteinpreproteinpreproproteinprecursorsprepropeptidepropeptidesPrepro
A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a piece of the molecule or adding on another molecule.wikipedia
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Post-translational modification

posttranslational modificationpost-translational modificationspost-translational
A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a piece of the molecule or adding on another molecule.
Other forms of post-translational modification consist of cleaving peptide bonds, as in processing a propeptide to a mature form or removing the initiator methionine residue.

Zymogen

proenzymezymogenspro-enzyme
Enzyme precursors are called zymogens or proenzymes.
A zymogen, also called a proenzyme, is an inactive precursor of an enzyme.

Protein

proteinsproteinaceousstructural proteins
A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a piece of the molecule or adding on another molecule.

Peptide

polypeptidepeptidespolypeptides
A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a piece of the molecule or adding on another molecule.

Molecule

molecularmoleculesmolecular structure
A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a piece of the molecule or adding on another molecule.

Proinsulin

Examples include proinsulin and proopiomelanocortin, which are both prohormones.

Proopiomelanocortin

pro-opiomelanocortinPOMCPOMC neurons
Examples include proinsulin and proopiomelanocortin, which are both prohormones.

Hormone

hormoneshormonalprohormone
Examples include proinsulin and proopiomelanocortin, which are both prohormones.

Enzyme

enzymologyenzymesenzymatic
Enzyme precursors are called zymogens or proenzymes.

Signal peptide

signal sequencetransit peptidetargeting sequence
Many of these are synthesized with an N-terminal signal peptide that targets them for secretion.

Endoplasmic reticulum

rough endoplasmic reticulumERsmooth endoplasmic reticulum
The signal peptide is cleaved off in the endoplasmic reticulum.

Procalcitonin

Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis.

Trypsinogen

Trypsinogen (EC 3.4.23.18/20/21/23/24/26) is the precursor form or zymogen of trypsin, a digestive enzyme.

Neuropeptide VF precursor

gonadotropin inhibitory hormoneNPVF
Neuropeptide VF precursor, also known as pro-FMRFamide-related neuropeptide VF or RFamide-related peptide precursor, is a propeptide that in mammals is encoded by the NPVF (or RPFP) gene.

TAC1

preprotachykinin-1beta-preprotachykininpreprotachykinin A
Preprotachykinin-1, (abbreviated PPT-1, PPT-I, or PPT-A), is a precursor protein that in humans is encoded by the TAC1 gene.

Caspase 1

caspase-1CASP1Caspase-1/Interleukin-1 converting enzyme
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursor s of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides.

Ricin

ricin toxin
The ricin precursor protein is 576 amino acid residues in length and contains a signal peptide (residues 1–35), the ricin A chain (36–302), a linker peptide (303–314), and the ricin B chain (315–576).

Interleukin-1 family

IL-1interleukin-1interleukin 1
All of the members of IL-1 family, except IL-1Ra, are first synthesized as a precursor protein, which means it is synthesized as a long form of a protein which has to be proteolytically cleaved to a shorter, active molecule, which is generally called a mature protein.

Granulin

GRNprogranulinhuman granulin gene
Progranulin is the precursor protein for granulin.

Preprotachykinin

preprotachykinin A gene
Preprotachykinins are precursor proteins that are modified into tachykinin peptides.

Complement system

complementcomplement cascadecomplement activation
The complement system consists of a number of small proteins that are synthesized by the liver, and circulate in the blood as inactive precursors.

Proteolysis

proteolyticprotein degradationpolyprotein
The precursor to the final functional form of protein is termed proprotein, and these proproteins may be first synthesized as preproprotein.

LRP1

CD91LDLR-related protein 1LRP
The LRP1 gene encodes a 600 kDa precursor protein that is processed by furin in the trans-Golgi complex, resulting in a 515 kDa alpha-chain and an 85 kDa beta-chain associated noncovalently.

Amatoxin

amatoxinsamanitin
All amatoxins are oligopeptides that are synthesized as 35-amino-acid proproteins, from which the final eight amino acids are cleaved by a prolyl oligopeptidase.