Proto-oncogene tyrosine-protein kinase Src

Srcc-Srcv-srcSrc (gene)src geneSRC kinasec-src genegenes, srcpp60 SRCSrc family
This article is about the kinase c-Src, for the kinase that phosphorylates c-Src, see CSK.wikipedia
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Tyrosine kinase

tyrosine kinasesprotein-tyrosine kinaseprotein tyrosine kinase
This protein phosphorylates specific tyrosine residues in other tyrosine kinases. c-Src includes an SH2 domain, an SH3 domain, and a tyrosine kinase domain.
To be specific, Lyn, a type of kinase in the Src family that was identified in the nuclear matrix, appears to control the cell cycle.

Tyrosine-protein kinase CSK

CSKC-src tyrosine kinaseSrc kinase
c-Src stands for "cellular Src kinase" and should not be confused with "C-terminal Src kinase" (CSK) which is an enzyme which phosphorylates c-Src at its C-terminus and provides negative regulation of Src's enzymatic activity.
This enzyme phosphorylates tyrosine residues located in the C-terminal end of Src-family kinases (SFKs) including SRC, HCK, FYN, LCK, LYN and YES1.

Non-receptor tyrosine kinase

EC 2.7.10.2Ncknon receptor tyrosine kinases
Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src, is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene.
CD4 and CD8 receptors on T lymphocytes require for their signaling the Src family member Lck.

Oncogene

oncogenesproto-oncogeneproto-oncogenes
Similarly, c-Src should not be mistaken for v-Src, a viral (hence the prefix v-) gene that shares similarity with c-Src and is also an oncogene, which can be found in Rous sarcoma virus.
The first confirmed oncogene was discovered in 1970 and was termed SRC (pronounced "sarc" as it is short for sarcoma).

V-Src

Src
Similarly, c-Src should not be mistaken for v-Src, a viral (hence the prefix v-) gene that shares similarity with c-Src and is also an oncogene, which can be found in Rous sarcoma virus.
The src gene is oncogenic as it triggers uncontrolled growth in abnormal host cells.

Src family kinase

SRCSrc family kinasesSrc-family kinase
It belongs to a family of Src family kinases.
Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily.

Rous sarcoma virus

Rous sarcomaRSVchicken sarcoma virus
Similarly, c-Src should not be mistaken for v-Src, a viral (hence the prefix v-) gene that shares similarity with c-Src and is also an oncogene, which can be found in Rous sarcoma virus.
The src gene is oncogenic as it triggers uncontrolled growth in abnormal host cells.

FYN

Fyn tyrosine kinase
There are 9 members part of the Src family kinases: c-Src, Yes, Fyn, Fgr, Yrk, Lyn, Blk, Hck, and Lck.

J. Michael Bishop

Michael BishopJohn Michael BishopJ. Michael Bishop, MD
Src (pronounced "sarc" as it is short for sarcoma) was originally discovered by J. Michael Bishop and Harold E. Varmus, for which they were awarded the 1989 Nobel Prize in Physiology or Medicine.
Working with Harold E. Varmus in the 1980s, he discovered the first human oncogene, c-Src.

Bosutinib

Bosulif
Other tyrosine kinase inhibitor drugs that are in clinical trials include bosutinib, bafetinib, AZD-530, XLl-999, KX01 and XL228.
Bosutinib (rINN/USAN; codenamed SKI-606, marketed under the trade name Bosulif) is a small molecule BCR-ABL and src tyrosine kinase inhibitor used for the treatment of chronic myelogenous leukemia.

SH2 domain

SH2ShcSrc homology 2
c-Src includes an SH2 domain, an SH3 domain, and a tyrosine kinase domain.
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins.

Receptor tyrosine kinase

receptor tyrosine kinasestyrosine kinase receptortyrosine kinase receptors
c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors.
Specific proteins containing these domains include Src and phospholipase Cγ.

STAT3

signal transducer and activator of transcription 3signal-transducer and activator of transcription 3STAT
Additionally, activation of STAT3 may occur via phosphorylation of serine 727 by Mitogen-activated protein kinases (MAPK) and through c-src non-receptor tyrosine kinase.

G protein-coupled receptor

G-protein coupled receptorG protein-coupled receptorsGPCR
c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors.
GPCRs may signal independently through many proteins already mentioned for their roles in G-protein-dependent signaling such as β-arrs, GRKs, and Srcs.

PTK2

focal adhesion kinaseFAKfocal adhesion kinase (FAK)
FAK is a highly conserved, non-receptor tyrosine kinase originally identified as a substrate for the oncogene protein tyrosine kinase v-src.

Myristoylation

myristoylatedN-myristoylationmyristolated
Src contains at least three flexible protein domains, which, in conjunction with myristoylation, can mediate attachment to membranes and determine subcellular localization.
c-Src is a gene that is important for normal mitotic cycling.

Dasatinib

BMS-354825Sprycel
One notable example is dasatinib which has been approved for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive (PH+) acute lymphocytic leukemia (ALL).
The main targets of dasatinib are BCR/Abl (the "Philadelphia chromosome"), Src, c-Kit, ephrin receptors, and several other tyrosine kinases.

Epidermal growth factor receptor

EGFREGF receptorEGFR inhibitor
Most studies have looked at the receptor tyrosine kinases and examples of these are platelet derived growth factor receptor (PDGFR) pathway and epidermal growth factor receptor (EGFR).

Paxillin

PXN
The proteins that bind to paxillin are diverse and include protein tyrosine kinases, such as Src and focal adhesion kinase (FAK), structural proteins, such as vinculin and actopaxin, and regulators of actin organization, such as COOL/PIX and PKL/GIT.

Gene

genesnumber of genesgene sequence
Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src, is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene.

Phosphorylation

phosphorylatedphosphorylatephosphorylates
This protein phosphorylates specific tyrosine residues in other tyrosine kinases.

Tyrosine

Tyrtyrosine metabolismL-tyrosine
This protein phosphorylates specific tyrosine residues in other tyrosine kinases.

C-terminus

C-terminalC-terminal domainC terminus
c-Src stands for "cellular Src kinase" and should not be confused with "C-terminal Src kinase" (CSK) which is an enzyme which phosphorylates c-Src at its C-terminus and provides negative regulation of Src's enzymatic activity.

SH3 domain

SH3SH3 bindingSH3 domain family
c-Src includes an SH2 domain, an SH3 domain, and a tyrosine kinase domain.