Receptor tyrosine kinase
receptor tyrosine kinasestyrosine kinase receptortyrosine kinase receptorsRTKreceptor protein-tyrosine kinasestyrosine kinasereceptor protein-tyrosine kinasetyrosine kinasesEC 126.96.36.199kinase inhibitors
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.wikipedia
246 Related Articles
EGFR familyEpidermal growth factor receptor familyEGF receptor family
The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member.
PDGFRplatelet derived growth factor receptorPDGF receptor
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family.
EC 188.8.131.52Ncknon receptor tyrosine kinases
Receptor tyrosine kinases are part of the larger family of protein tyrosine kinases, encompassing the receptor tyrosine kinase proteins which contain a transmembrane domain, as well as the non receptor tyrosine kinases which do not possess transmembrane domains.
Unlike the receptor tyrosine kinases (RTKs), the second subgroup of tyrosine kinases, the non-receptor tyrosine kinases are cytosolic enzymes.
Most RTKs are single subunit receptors but some exist as multimeric complexes, e.g., the insulin receptor that forms disulfide linked dimers in the presence of hormone (insulin); moreover, ligand binding to the extracellular domain induces formation of receptor dimers.
The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors.
TRKTrk proteinsneurotrophic tyrosine kinase receptor (NTKR) family
Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.
Tyrosine-protein kinase-like 7 also known as colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is encoded by the PTK7 gene.
class IIIreceptor tyrosine kinase III family
RTK class III is a class of receptor tyrosine kinases.
Eph receptorEphrinEphrin receptors
Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs).
METproto-oncogene proteins c-metHepatocyte growth factor receptor
MET is a receptor tyrosine kinase (RTK) that is produced as a single-chain precursor.
RETproto-oncogene proteins c-retRET receptor
The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular signalling molecules.
AXLAXL kinaseAXL receptor
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily.
MuSKMuSK receptorMuscle-specific kinase
MuSK (for Muscle-Specific Kinase) is a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular junction.
c-ros oncogene 1ROS receptor
ROS1 is a receptor tyrosine kinase (encoded by the gene ROS1) with structural similarity to the anaplastic lymphoma kinase (ALK) protein; it is encoded by the c-ros oncogene and was first identified in 1986.
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment.
In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in regulating skeletal and neuronal development, cell migration and cell polarity.
transmembrane receptorreceptorcell surface receptors
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.
SH2ShcSrc homology 2
The phosphorylation of specific tyrosine residues within the activated receptor creates binding sites for Src homology 2 (SH2) domain- and phosphotyrosine binding (PTB) domain-containing proteins.
SH2 domains are commonly found in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways.
In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal, extracellular ligand-binding domain, a transmembrane spanning domain and a C-terminal intracellular domain.
Specific proteins containing these domains include Src and phospholipase Cγ.
c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors.
An example of a vital signal transduction pathway involves the tyrosine kinase receptor, c-met, which is required for the survival and proliferation of migrating myoblasts during myogenesis.
c-Met is a tyrosine kinase receptor that is required for the survival and proliferation of migrating myoblasts.
signaling pathwayssignaling cascadesignal transduction pathways
Phosphorylation and activation of these two proteins on receptor binding lead to the initiation of signal transduction pathways. These adaptor proteins link RTK activation to downstream signal transduction pathways, such as the MAP kinase signalling cascade.
Receptor tyrosine kinases (RTKs) are transmembrane proteins with an intracellular kinase domain and an extracellular domain that binds ligands; examples include growth factor receptors such as the insulin receptor.
When a growth factor binds to the extracellular domain of a RTK, its dimerization is triggered with other adjacent RTKs.
catalytic receptorCatalytic receptors
tyrosine kinasesprotein-tyrosine kinaseprotein tyrosine kinase
Receptor tyrosine kinases are part of the larger family of protein tyrosine kinases, encompassing the receptor tyrosine kinase proteins which contain a transmembrane domain, as well as the non receptor tyrosine kinases which do not possess transmembrane domains. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins.
By 2004, 58 receptor tyrosine kinases (RTKs) were known, grouped into 20 subfamilies.
MAPKMAP kinasemitogen-activated protein kinases
These adaptor proteins link RTK activation to downstream signal transduction pathways, such as the MAP kinase signalling cascade.
Indeed, many of the proto-oncogenic "driver" mutations are tied to ERK1/2 signaling, such as constitutively active (mutant) receptor tyrosine kinases, Ras or Raf proteins.