Reuptake

re-uptakereabsorptionuptake reuptake inhibitorsneurotransmitter reuptakereuptake of these neurotransmitterstransports
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.wikipedia
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Neurotransmitter

neurotransmittersexcitatory neurotransmitterneurotransmitter system
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.
A released neurotransmitter is typically available in the synaptic cleft for a short time before it is metabolized by enzymes, pulled back into the presynaptic neuron through reuptake, or bound to a postsynaptic receptor.

Dopamine

dopaminergic systemDAdopaminergic
The members of this new family include transporters for dopamine, norepinephrine, serotonin, glycine, proline and GABA.
The anticipation of most types of rewards increases the level of dopamine in the brain, and many addictive drugs increase dopamine release or block its reuptake into neurons following release.

Serotonin

5-HTserotonergic5-hydroxytryptamine
The members of this new family include transporters for dopamine, norepinephrine, serotonin, glycine, proline and GABA.
Several classes of antidepressants, such as the SSRIs and the SNRIs among others, interfere with the normal reabsorption of serotonin after it is done with the transmission of the signal, therefore augmenting the neurotransmitter levels in the synapses.

Norepinephrine

noradrenalinenoradrenergicnoradrenalin
The members of this new family include transporters for dopamine, norepinephrine, serotonin, glycine, proline and GABA.
They are then absorbed back into the presynaptic cell, via reuptake mediated primarily by the norepinephrine transporter (NET).

Serotonin transporter

SERTserotoninSLC6A4
From the conformational differences between the structure of TMs 1-5 and that of TMs 6-10, and from the identification of a substrate permeation pathway between the binding site of SERT and the cytoplasm, a mechanism for conformational change was proposed in which a four-helix bundle composed of TMs 1, 2, 6 and 7 changes its orientation within the rest of the protein.
SERT is a type of monoamine transporter protein that transports serotonin from the synaptic cleft back to the presynaptic neuron.

Reuptake inhibitor

inhibitinhibitorinhibiting
The main objective of a reuptake inhibitor is to substantially decrease the rate by which neurotransmitters are reabsorbed into the presynaptic neuron, increasing the concentration of neurotransmitter in the synapse.
A reuptake inhibitor (RI) is a type of drug known as a reuptake modulator that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron.

Selective serotonin reuptake inhibitor

SSRIselective serotonin reuptake inhibitorsSSRIs
They presented SERT with varying doses of either citalopram (an SSRI) or desipramine (an inhibitor of norepinephrine reuptake protein, NET).
SSRIs function by increasing the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the presynaptic cell, increasing the level of serotonin in the synaptic cleft available to bind to the postsynaptic receptor.

Tricyclic antidepressant

tricyclic antidepressantsTCAsTCA
It was initially supported by the successful reduction of depressive symptoms after administration of tricyclic antidepressants (such as desipramine) and SSRIs.
Most of the TCAs inhibit the reuptake of norepinephrine, though not dopamine, and as a result, they show some efficacy in remedying the disorder.

Dopamine transporter

DATdopamineSLC6A3
It has been shown that AMPH acts upon trace amine-associated receptor 1 (TAAR1) to induce efflux and reuptake inhibition in the serotonin, norepinephrine, and dopamine transporters.
The human dopamine transporter (hDAT) contains a high affinity extracellular zinc binding site which, upon zinc binding, inhibits dopamine reuptake and amplifies amphetamine-induced dopamine efflux in vitro.

Neurotransmitter transporter

transporteruptakeneurotransmitter transporters
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

Cell membrane

plasma membranemembranecell membranes
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

Axon terminal

axon terminalspostsynaptic terminalaxonal terminal
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

Synapse

synapsessynapticpresynaptic
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

Neuron

neuronsnerve cellsnerve cell
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

Glia

glial cellsglial cellglial
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

Action potential

action potentialsnerve impulsenerve impulses
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

Membrane transport protein

carrier proteintransportertransporters
Because neurotransmitters are too large and hydrophilic to diffuse through the membrane, specific transport proteins are necessary for the reabsorption of neurotransmitters.

Glycine

GlyGglycinate
The members of this new family include transporters for dopamine, norepinephrine, serotonin, glycine, proline and GABA. In TM1, an aspartate distinguishes monoamine NSS transporters from amino acid transporters which contain a glycine at the same position.

Proline

ProL-proline L -proline
The members of this new family include transporters for dopamine, norepinephrine, serotonin, glycine, proline and GABA.

Gamma-Aminobutyric acid

GABAγ-aminobutyric acidGABAergic
The members of this new family include transporters for dopamine, norepinephrine, serotonin, glycine, proline and GABA.

Sodium

NaNa + sodium ion
Sodium and chloride ion dependence will be discussed later in the mechanism of action.

Chloride

Cl − chloridesCl
Sodium and chloride ion dependence will be discussed later in the mechanism of action.

Aquifex aeolicus

A. aeolicus
One of these proteins, LeuT, from Aquifex aeolicus, was crystallized by Yamashita et al. with very high resolution, revealing a molecule of leucine and two Na + ions bound near the center of the protein.

Aspartic acid

aspartateAspL-aspartate
In TM1, an aspartate distinguishes monoamine NSS transporters from amino acid transporters which contain a glycine at the same position.

Monoamine neurotransmitter

monoaminemonoaminesmonoamine neurotransmitters
In TM1, an aspartate distinguishes monoamine NSS transporters from amino acid transporters which contain a glycine at the same position.