Potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism.- Septic shock
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Intensive therapy unit or intensive treatment unit (ITU) or critical care unit (CCU), is a special department of a hospital or health care facility that provides intensive care medicine.
Common conditions that are treated within ICUs include acute respiratory distress syndrome, septic shock, and other life-threatening conditions.
Altered organ function in an acutely ill patient requiring medical intervention to achieve homeostasis.
Sepsis is the most common cause of multiple organ dysfunction syndrome and may result in septic shock.
Bloodstream infections (BSIs), which include bacteremias when the infections are bacterial and fungemias when the infections are fungal, are infections present in the blood.
The immune response to the bacteria can cause sepsis and septic shock, which has a high mortality rate.
Protein complex that controls transcription of DNA, cytokine production and cell survival.
Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.
Gram-negative bacteria are bacteria that do not retain the crystal violet stain used in the Gram staining method of bacterial differentiation.
This toxic reaction may lead to low blood pressure, respiratory failure, reduced oxygen delivery, and lactic acidosis — manifestations of septic shock.
Lipopolysaccharides (LPS) are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria.
When bacterial cells are lysed by the immune system, fragments of membrane containing lipid A are released into the circulation, causing fever, diarrhea, and possible fatal endotoxic shock (also called septic shock).
Genus of rod-shaped Gram-negative bacteria of the family Enterobacteriaceae.
This can lead to life-threatening hypovolemic shock and septic shock, and requires intensive care including antibiotics.
Life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs.
Septic shock is low blood pressure due to sepsis that does not improve after fluid replacement.
Adipokine and a cytokine.
Kevin J. Tracey and Cerami discovered the key mediator role of TNF in lethal septic shock, and identified the therapeutic effects of monoclonal anti-TNF antibodies.
Low blood pressure.
4) Address the underlying problem (i.e., antibiotic for infection, stent or CABG (coronary artery bypass graft surgery) for infarction, steroids for adrenal insufficiency, etc...)