Septic shock

septicshockshock, septicdangerously low blood pressureendotoxic shockinfection
Septic shock is a potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism.wikipedia
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Sepsis

septicaemiablood poisoningseptic
Septic shock is a potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism.
Septic shock is low blood pressure due to sepsis that does not improve after fluid replacement.

Multiple organ dysfunction syndrome

multiple organ failuremulti-organ failuremultiorgan failure
It can cause multiple organ dysfunction syndrome (formerly known as multiple organ failure) and death.
Sepsis is the most common cause of Multiple Organ Dysfunction Syndrome and may result in septic shock.

Bacteremia

bacteraemiatoxemiatoxaemia
The precipitating infections that may lead to septic shock if severe enough include but are not limited to appendicitis, pneumonia, bacteremia, diverticulitis, pyelonephritis, meningitis, pancreatitis, necrotizing fasciitis, MRSA and mesenteric ischemia.
The immune response to the bacteria can cause sepsis and septic shock, which has a high mortality rate.

Pyelonephritis

kidney infectionpyelitisurosepsis
The precipitating infections that may lead to septic shock if severe enough include but are not limited to appendicitis, pneumonia, bacteremia, diverticulitis, pyelonephritis, meningitis, pancreatitis, necrotizing fasciitis, MRSA and mesenteric ischemia.
Pyelonephritis that has progressed to urosepsis may be accompanied by signs of septic shock, including rapid breathing, decreased blood pressure, shivering, and occasionally delirium.

Gram-negative bacteria

Gram-negativeGram negativeGram-negative bacterium
Most cases of septic shock are caused by gram-positive bacteria, followed by endotoxin-producing gram-negative bacteria, although fungal infections are an increasingly prevalent cause of septic shock.
This toxic reaction can include fever, an increased respiratory rate, and low blood pressure — a life-threatening condition known as septic shock.

Salmonella

Salmonella poisoningSalmonella typhibacteremic salmonellosis
Recently, severe damage to liver ultrastructure has been noticed from treatment with cell-free toxins of Salmonella.
This can lead to life-threatening hypovolemic shock and septic shock, and requires intensive care including antibiotics.

Tumor necrosis factor alpha

TNF-αTNF-alphaTNFα
It also results in profound activation of mononuclear cells and the production of potent effector cytokines such as IL-1, IL-6, and TNF-α.
Kevin J. Tracey and Cerami discovered the key mediator role of TNF in lethal septic shock, and identified the therapeutic effects of monoclonal anti-TNF antibodies.

Hypotension

low blood pressurehypotensivelow
Septic shock is a potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism.

Distributive shock

distributive
Septic shock is a subclass of distributive shock, a condition in which abnormal distribution of blood flow in the smallest blood vessels results in inadequate blood supply to the body tissues, resulting in ischemia and organ dysfunction.
The most common cause is sepsis leading to type of distributive shock called septic shock, a condition that can be fatal.

Early goal-directed therapy

Early goal directed therapyGoal-directed therapyEarly Goal Directed Therapy (EGDT)
Early goal-directed therapy is a more specific form of therapy used for the treatment of severe sepsis and septic shock.

Fluid replacement

fluid resuscitationhydrationrehydration
Because lowered blood pressure in septic shock contributes to poor perfusion, fluid resuscitation is an initial treatment to increase blood volume.

Ischemia

ischemicischaemiaischaemic
Septic shock is a subclass of distributive shock, a condition in which abnormal distribution of blood flow in the smallest blood vessels results in inadequate blood supply to the body tissues, resulting in ischemia and organ dysfunction.

Lipopolysaccharide

endotoxinLPSlipopolysaccharides
Toxins produced by pathogens cause an immune response; in gram-negative bacteria these are endotoxins, which are bacterial membrane lipopolysaccharides (LPS).
When bacterial cells are lysed by the immune system, fragments of membrane containing lipid A are released into the circulation, causing fever, diarrhea, and possible fatal endotoxic shock (also called septic shock).

Methylene blue

Methylthioninium chloride
Methylene blue has been found to be useful for this condition.
It has also been used in septic shock and anaphylaxis.

Norepinephrine (medication)

norepinephrineNoradrenalinedrug
Among the choices for vasopressors, norepinephrine is superior to dopamine in septic shock.
Norepinephrine is used mainly as a sympathomimetic drug to treat people in vasodilatory shock states such as septic shock and neurogenic shock, while showing fewer adverse side-effects compared to dopamine treatment.

Vasopressin

antidiuretic hormoneADHarginine vasopressin
Low-dose vasopressin also may be used as an addition to norepinephrine, but is not recommended as a first-line treatment.
Vasopressin infusions are also used as second line therapy for septic shock patients not responding to fluid resuscitation or infusions of catecholamines (e.g., dopamine or norepinephrine) to increase the blood pressure while sparing the use of catecholamines.

Medicine

medicalmedical scienceclinical medicine
Septic shock is a potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism.

Infection

infectious diseaseinfectious diseasesinfections
Septic shock is a potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism.

Lactate dehydrogenase

LDHlactic acid dehydrogenaselactic dehydrogenase
Patients with septic shock can be clinically identified by a vasopressor requirement to maintain a mean arterial pressure of 65 mm Hg or greater and serum lactate level greater than 2 mmol/L (>18 mg/dL) in the absence of hypovolemia.

Hypovolemia

hemorrhagic shockhypovolemic shockvolume depletion
Patients with septic shock can be clinically identified by a vasopressor requirement to maintain a mean arterial pressure of 65 mm Hg or greater and serum lactate level greater than 2 mmol/L (>18 mg/dL) in the absence of hypovolemia.

Bacteria

bacteriumbacterialEubacteria
The primary infection is most commonly caused by bacteria, but also may be by fungi, viruses or parasites.

Fungus

Fungifungalnecrotrophic
The primary infection is most commonly caused by bacteria, but also may be by fungi, viruses or parasites.

Virus

virusesviralvirion
The primary infection is most commonly caused by bacteria, but also may be by fungi, viruses or parasites.

Parasitism

parasiteparasiticparasites
The primary infection is most commonly caused by bacteria, but also may be by fungi, viruses or parasites.

Urinary system

urinary tracturinaryrenal system
It may be located in any part of the body, but most commonly in the lungs, brain, urinary tract, skin or abdominal organs.