Shikimate pathway

shikimic acid pathwaypathwayShikimate acid pathwayshikimic acid biosynthesis pathway
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).wikipedia
72 Related Articles

DAHP synthase

3-deoxy-7-phosphoheptulonate synthase
The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase.
3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan.

Tyrosine

Tyrtyrosine metabolismphosphotyrosine
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).
In plants and most microorganisms, tyr is produced via prephenate, an intermediate on the shikimate pathway.

3-dehydroquinate synthase

The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase.
This reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids.

Aromatic amino acid

aromatic amino acidsaromaticaromatic residues
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).
Animals obtain aromatic amino acids from their diet, but all plants and micro-organisms must synthesize their aromatic amino acids through the metabolically costly shikimate pathway in order to make them.

Erythrose 4-phosphate

erythrose-4-phosphate D -erythrose 4-phosphate
The pathway starts with two substrates, phosphoenol pyruvate and erythrose-4-phosphate and ends with chorismate, a substrate for the three aromatic amino acids.
It is used in the first step of the shikimate pathway.

Chorismate mutase

c'''horismate mutaseCM_mono2
Prephenic acid is then synthesized by a Claisen rearrangement of chorismate by chorismate mutase.
In enzymology, chorismate mutase is an enzyme that catalyzes the chemical reaction for the conversion of chorismate to prephenate in the pathway to the production of phenylalanine and tyrosine, also known as the shikimate pathway.

3-dehydroquinate dehydratase

The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase.
In fungi, dehydroquinase is part of a multifunctional enzyme which catalyses five consecutive steps in the shikimate pathway.

EPSP synthase

5-enolpyruvylshikimate-3-phosphate synthase3-phosphoshikimate 1-carboxyvinyltransferase5-enolpyruvylshikimate-3-phosphate
The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase.
Glyphosate is a competitive inhibitor of PEP, acting as a transition state analog that binds more tightly to the EPSPS-S3P complex than PEP and inhibits the shikimate pathway.

Shikimic acid

shikimateshikimate pathwayshikimic
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

Metabolic pathway

metabolic pathwayspathwaypathways
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan). This pathway is not found in animals, which require these amino acids, hence the products of this pathway represent essential amino acids that must be obtained from organisms that are not animals (or animals which eat those organisms) in the animal's diet.

Bacteria

bacteriumbacterialeubacteria
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

Archaea

archaeonarcheaarchaebacteria
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

Fungus

fungifungalnecrotrophic
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

Algae

algaalgalfilamentous algae
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

Protozoa

protozoanprotozoanspellicle
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

Plant

plantsfloraplant kingdom
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

Biosynthesis

synthesisproductionbiosynthetic
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

Folate

folic acidfolate biosynthesisone carbon pool by folate
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

Phenylalanine

Phephenylalanine metabolism L -phenylalanine
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

Tryptophan

Trptryptophan metabolism L -tryptophan
The shikimate pathway (shikimic acid pathway) is a seven step metabolic route used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

Essential amino acid

essential amino acidsessentialnon-essential amino acid
This pathway is not found in animals, which require these amino acids, hence the products of this pathway represent essential amino acids that must be obtained from organisms that are not animals (or animals which eat those organisms) in the animal's diet.

Shikimate dehydrogenase

The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase.

Shikimate kinase

The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase.

Chorismate synthase

The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase.

Substrate (chemistry)

substratessubstrateenzyme substrate
The pathway starts with two substrates, phosphoenol pyruvate and erythrose-4-phosphate and ends with chorismate, a substrate for the three aromatic amino acids.