Stratum granulosum

granular layerGranular layer of skingranulosumstratum granulosum (granular layer)
The stratum granulosum (or granular layer) is a thin layer of cells in the epidermis.wikipedia
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Epidermis

epidermalepidermal cellsepidermal layer
The stratum granulosum (or granular layer) is a thin layer of cells in the epidermis.

Keratinocyte

keratinocytesskin cellsdead skin cells
Keratinocytes migrating from the underlying stratum spinosum become known as granular cells in this layer.
During this differentiation process, keratinocytes permanently withdraw from the cell cycle, initiate expression of epidermal differentiation markers, and move suprabasally as they become part of the stratum spinosum, stratum granulosum, and eventually corneocytes in the stratum corneum.

Stratum spinosum

prickle cell layerspinosumspinous layer
Keratinocytes migrating from the underlying stratum spinosum become known as granular cells in this layer.
The stratum spinosum (or spinous layer/prickle cell layer) is a layer of the epidermis found between the stratum granulosum and stratum basale.

Keratohyalin

These cells contain keratohyalin granules, which are filled with histidine- and cysteine-rich proteins that appear to bind the keratin filaments together.
Keratohyalin, is a protein structure found in granules in the stratum granulosum of the epidermis, which may be involved in keratinization, and in Hassall's corpuscles in the thymus.

Lamellar bodies

Lamellar granulesextracellular lipid lamellaemultilamellar bodies
At the transition between this layer and the stratum corneum, cells secrete lamellar bodies (containing lipids and proteins) into the extracellular space.
In the upper stratum spinosum and stratum granulosum layers of the epidermis, lamellar bodies are secreted from keratinocytes, resulting in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.

Stratum corneum

horny layercornified layerepidermal permeability barrier
At the transition between this layer and the stratum corneum, cells secrete lamellar bodies (containing lipids and proteins) into the extracellular space.

Corneocyte

corneocytescornified cell envelope
Concomitantly, cells lose their nuclei and organelles causing the granular cells to become non-viable corneocytes in the stratum corneum.
From the site of production, lamellar bodies migrate to the top of the stratum granulosum and then into the intercellular domain of the stratum corneum to extrude their contents, which are predominantly lipids.

Lipid

lipidsglycerolipidfat
At the transition between this layer and the stratum corneum, cells secrete lamellar bodies (containing lipids and proteins) into the extracellular space.

Protein

proteinsproteinaceousstructural proteins
At the transition between this layer and the stratum corneum, cells secrete lamellar bodies (containing lipids and proteins) into the extracellular space.

Hydrophobe

hydrophobichydrophobicityhydrophobic interaction
This results in the formation of the hydrophobic lipid envelope responsible for the skin's barrier properties.

Cell nucleus

nucleusnucleinuclear
Concomitantly, cells lose their nuclei and organelles causing the granular cells to become non-viable corneocytes in the stratum corneum.

Organelle

organellescell organellescell organelle
Concomitantly, cells lose their nuclei and organelles causing the granular cells to become non-viable corneocytes in the stratum corneum.

List of skin conditions

List of cutaneous conditionsList of skin diseasesskin conditions
The epidermis is the most superficial layer of skin, a squamous epithelium with several strata: the stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and stratum basale.

KLK7

kallikrein 7
KLK7 is secreted as an inactive zymogen in the stratum granulosum layer of the epidermis, requiring proteolytic cleavage of the short N-terminal pro-region to liberate activated enzyme.

Trichohyalin

TCHH
It was also detected in the granular layer and stratum corneum of normal epidermis, newborn human foreskin epidermis, the hard palate, in the nail matrix, the filiform papillae of dorsal tongue epithelium and in rodent forestomack.

Hypergranulosis

Hypergranulosis is an increased thickness of the stratum granulosum.

Vaginal epithelium

cervical fluidlining of the vaginavaginal mucus
Under the stratus corneum is the stratum granulosum and stratum spinosum.

ALOXE3

Immunologically detected ALOXE3 and ALOX12B in humans and Aloxe3 and Alox12b in mice have a similar tissue distribution in being highly expressed in the outer, differentiated layers of the epidermis; they co-localize at the surface of keratinocytes in the stratum granulosum of mouse skin and during mouse embryogenesis appear concurrently at the onset of skin development at day 15.5.

Dyskeratosis

dyskeratotic
Dyskeratosis is abnormal keratinization occurring prematurely within individual cells or groups of cells below the stratum granulosum.

Stratum lucidum

dead skin layer
Located between the stratum granulosum and stratum corneum layers, it is composed of three to five layers of dead, flattened keratinocytes.

Skin condition

Skin lesionskin diseasepustule
The epidermis is the most superficial layer of skin, a squamous epithelium with several strata: the stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and stratum basale.

Head and neck anatomy

head and neckneck or templeVeins of the head and neck

Filaggrin

FLGprofilaggrin
In the epidermis, these structures are present in the keratohyalin granules in cells of the stratum granulosum.