TRPC4

The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.wikipedia
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Transient receptor potential channel

transient receptor potentialTRPtransient receptor potential channels
TrpC4 is a member of the transient receptor potential cation channels.

TRPC5

TRPC4 has been shown to interact with ITPR1, TRPC1, and TRPC5.
The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4.

ITPR1

inositol 1,4,5-trisphosphate receptor, type 1
TRPC4 has been shown to interact with ITPR1, TRPC1, and TRPC5.

TRPC1

TRPC4 has been shown to interact with ITPR1, TRPC1, and TRPC5.

TRPC

transient receptor potential canonicaltransient receptor potential canonical (TRPC) family channels
* TRPC
* TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7

Protein

proteinsproteinaceousstructural proteins
The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.

Gene

genesnumber of genesgene sequence
The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.

Gq alpha subunit

G q GαqG q alpha subunit
This protein forms a non-selective calcium-permeable cation channel that is activated by Gαi-coupled receptors, Gαq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation.

G protein-coupled receptor

G-protein coupled receptorG protein-coupled receptorsGPCR
This protein forms a non-selective calcium-permeable cation channel that is activated by Gαi-coupled receptors, Gαq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation.

Tyrosine kinase

tyrosine kinasesprotein-tyrosine kinaseprotein tyrosine kinase
This protein forms a non-selective calcium-permeable cation channel that is activated by Gαi-coupled receptors, Gαq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation.

Endothelium

endothelialendothelial cellsendothelial cell
This protein forms a non-selective calcium-permeable cation channel that is activated by Gαi-coupled receptors, Gαq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation.

Vasodilation

vasodilatorvasodilatorsvasodilatation
This protein forms a non-selective calcium-permeable cation channel that is activated by Gαi-coupled receptors, Gαq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation.

Neurotransmitter

neurotransmittersexcitatory neurotransmitterneurotransmitter system
This protein forms a non-selective calcium-permeable cation channel that is activated by Gαi-coupled receptors, Gαq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation.

Cortex (anatomy)

cortexcorticalcortical surface
The nonselective cation channel TrpC4 has been shown to be present in high abundance in the cortico-limbic regions of the brain.

Limbic system

limbiclimbic structureslimbic region
The nonselective cation channel TrpC4 has been shown to be present in high abundance in the cortico-limbic regions of the brain.

Dopaminergic

dopaminergic drugsdopaminergic neuronsDA
In addition, TRPC4 mRNA is present in midbrain dopaminergic neurons in the ventral tegmental area and the substantia nigra.

Ventral tegmental area

ventral tegmentumventral tegmental area (VTA)ventral tegmental nuclei
In addition, TRPC4 mRNA is present in midbrain dopaminergic neurons in the ventral tegmental area and the substantia nigra.

Substantia nigra

substantia nigra pars reticulatanigralsubstantia nigra pars compacta
In addition, TRPC4 mRNA is present in midbrain dopaminergic neurons in the ventral tegmental area and the substantia nigra.

Single-nucleotide polymorphism

single nucleotide polymorphismSNPSNPs
Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity.

Generalized epilepsy

generalized seizuregeneralized seizuresgeneralized
Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity.

Photosensitive epilepsy

photosensitive epilepticepileptogenicphotosensitive seizures
Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity.

Protein–protein interaction

interactprotein-protein interactionsprotein-protein interaction
TRPC4 has been shown to interact with ITPR1, TRPC1, and TRPC5.

Cation channel superfamily

Ion channel familychannel familysuperfamily of cation channels
* TRPC1; TRPC3; TRPC4; TRPC5; TRPC6; TRPC7

RASD1

Dexras1
RASD1 is also reported to function with leptin in the activation of TRPC4 transient receptor potential channels and, thus, plays a role in regulating electrical excitability in gastrointestinal myocytes, pancreatic β-cells, and neurons.