TRPC6

below
Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name.wikipedia
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Transient receptor potential channel

transient receptor potentialTRPtransient receptor potential channels
TRPC6 is a transient receptor potential ion channel.

Focal segmental glomerulosclerosis

focal segmental glomerular sclerosisFSGSFocal and segmental glomerular lesions
It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).

Adhyperforin

Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin.
It has a very similar pharmacological profile to hyperforin and acts as a TRPC6 ion channel activator, thereby inhibiting the reuptake of various neurotransmitters including serotonin, norepinephrine, dopamine, GABA, and glutamate.

TRPC2

TRPC2 has been shown to interact with TRPC6.

TRPC3

A commercially available inhibitor is available in the form of a pyrazole compound, Pyr3 TRPC3 has been shown to specifically interact with TRPC1 and TRPC6.

Reuptake inhibitor

inhibitinhibitorinhibiting
These compounds are inhibitors of the reuptake of serotonin, norepinephrine, dopamine, γ-aminobutyric acid, and glutamate, and they are reported to exert these effects by binding to and activating TRPC6.
Hyperforin and adhyperforin are wide-spectrum inhibitors of the reuptake of serotonin, norepinephrine, dopamine, glutamate, GABA, glycine, and choline, and they exert these effects by binding to and activating the transient receptor potential cation channel TRPC6.

Human

humanshuman beinghuman beings
Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name.

Gene

genesnumber of genesgene sequence
Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name.

Protein

proteinsproteinaceousstructural proteins
Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name.

Ion channel

ion channelschannelchannels
TRPC6 is a transient receptor potential ion channel.

Depression (mood)

depressiondepressedmelancholy
It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).

Anxiety

anxiousnervousnessanxieties
It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).

Antidepressant

antidepressantsanti-depressantanti-depressants
Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin.

Anxiolytic

anxiolysisanti-anxietyanxiolytics
Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin.

Therapeutic effect

effecttherapeuticbenefit
Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin.

Hypericum perforatum

St. John's wortSt John's wortSt. John’s wort
Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin.

Hyperforin

Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin.

Reuptake

re-uptakereabsorptionuptake
These compounds are inhibitors of the reuptake of serotonin, norepinephrine, dopamine, γ-aminobutyric acid, and glutamate, and they are reported to exert these effects by binding to and activating TRPC6.

Serotonin

5-HTserotonergic5-hydroxytryptamine
These compounds are inhibitors of the reuptake of serotonin, norepinephrine, dopamine, γ-aminobutyric acid, and glutamate, and they are reported to exert these effects by binding to and activating TRPC6.

Norepinephrine

noradrenalinenoradrenergicnoradrenalin
These compounds are inhibitors of the reuptake of serotonin, norepinephrine, dopamine, γ-aminobutyric acid, and glutamate, and they are reported to exert these effects by binding to and activating TRPC6.

Dopamine

dopaminergic systemDAdopaminergic
These compounds are inhibitors of the reuptake of serotonin, norepinephrine, dopamine, γ-aminobutyric acid, and glutamate, and they are reported to exert these effects by binding to and activating TRPC6.

Gamma-Aminobutyric acid

GABAγ-aminobutyric acidGABAergic
These compounds are inhibitors of the reuptake of serotonin, norepinephrine, dopamine, γ-aminobutyric acid, and glutamate, and they are reported to exert these effects by binding to and activating TRPC6.

Glutamic acid

glutamateL-glutamateGlu
These compounds are inhibitors of the reuptake of serotonin, norepinephrine, dopamine, γ-aminobutyric acid, and glutamate, and they are reported to exert these effects by binding to and activating TRPC6.