Telethonin

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).

Protein that in humans is encoded by the TCAP gene.

- Telethonin

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T-tubule

T-tubules (transverse tubules) are extensions of the cell membrane that penetrate into the centre of skeletal and cardiac muscle cells.

Skeletal muscle fiber, with T-tubule labelled in zoomed in image.

Titin capping protein known as telethonin is encoded by the TCAP gene and helps with T-tubule development and is potentially responsible for the increasing number of T-tubules seen as muscles grow.

Titin

Protein that in humans is encoded by the gene.

Titin Ig domains. a) Schematic of part of a sarcomere b) Structure of Ig domains c) Topology of Ig domains.
Protein domains of Titin A-band. White boxes are Fn3 domains, red boxes are Ig domains, yellow boxes are Fn3 domains with the -AVNKYG- sequence, and the black box is protein kinase domain.
Sliding filament model of muscle contraction. (Titin labeled at upper right.)

Z line region: telethonin and alpha-actinin

CSRP3

Protein that in humans is encoded by the CSRP3 gene.

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).

1) Z-line, including telethonin (T-cap), alpha-actinin (ACTN), cofilin-2 (CFL2), calcineurin, HDAC4, MLP-b as well as to MLP itself;

MYOZ1

Protein that in humans is encoded by the MYOZ1 gene.

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).

MYOZ1 has been shown to interact with Telethonin, FLNC and Actinin, alpha 2.

ANKRD2

Protein that in humans is encoded by the ANKRD2 gene.

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).

TCAP,

MYOZ2

Protein that in humans is encoded by the MYOZ2 gene.

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).

Calsarcin-1 binds to alpha-actinin, gamma-filamin, telethonin, ZASP/Cypher and calcineurin.

List of OMIM disorder codes

List of disorder codes in the Online Mendelian Inheritance in Man database.

Graphical representation of the idealized human diploid karyotype, showing the organization of the genome into chromosomes. This drawing shows both the male (XY) and female (XX) versions of the 23rd chromosome pair. Chromosomes are shown aligned at their centromeres. The mitochondrial DNA is not shown.

Cardiomyopathy, dilated, 1N; ; TCAP