Trk receptor

TRKTrk proteinsneurotrophic tyrosine kinase receptor (NTKR) familyNGF receptorTrk A/BTrk familytropomyosin receptor kinase
Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.wikipedia
107 Related Articles

Receptor tyrosine kinase

receptor tyrosine kinasestyrosine kinase receptortyrosine kinase receptors
Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.

Neurotrophin

neurotrophinsneurotrophicmicroneurotrophin
The common ligands of trk receptors are neurotrophins, a family of growth factors critical to the functioning of the nervous system.
These two proteins are p75 (NTR), which binds to all neurotrophins, and subtypes of Trk, which are each specific for different neurotrophins.

Oncogene

oncogenesproto-oncogeneproto-oncogenes
The family of Trk receptors is named for the oncogene trk, whose identification led to the discovery of its first member, TrkA.
Examples of proto-oncogenes include RAS, WNT, MYC, ERK, and TRK.

Axon

axonsnerve fiberaxonal
The axons of these proprioceptive sensory neurons are much thicker than those of nociceptive sensory neurons, which express trkA.
The neurotrophic factors – nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NTF3) are also involved in axon development and bind to Trk receptors.

Tropomyosin receptor kinase A

TrkANTRK1NTRK
The family of Trk receptors is named for the oncogene trk, whose identification led to the discovery of its first member, TrkA.
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family.

Entrectinib

Rozlytrek
Entrectinib (formerly RXDX-101, trade name Rozlytrek) is an investigational drug developed by Ignyta, Inc., which has potential antitumor activity.
It is a selective tyrosine kinase inhibitor (TKI), of the tropomyosin receptor kinases (Trk) A, B and C, C-ros oncogene 1 (ROS1) and anaplastic lymphoma kinase (ALK).

MAPK/ERK pathway

MAPK/ERKMAPKMAPK signaling pathway
The three known pathways are PLC, Ras/MAPK (mitogen-activated protein kinase) and the PI3K (phosphatidylinositol 3-kinase) pathways.
Apart from EGFR, other cell surface receptors that can activate this pathway via GRB2 include Trk A/B, Fibroblast growth factor receptor (FGFR) and PDGFR.

Larotrectinib

LOXO-101Vitrakvi
Originally targeting soft tissue sarcomas, Larotrectinib (tradename Vitrakvi) was approved in November 2018 as a tissue-agnostic inhibitor of TrkA, TrkB, and TrkC developed by Array BioPharma for solid tumors with NTRK fusion mutations.

Tropomyosin receptor kinase B

TrkBTropomyosin receptor kinase B § AgonistsTrkB receptor
TrkB has the highest affinity to the binding of brain-derived neurotrophic factor (BDNF) and NT-4.
* Trk receptor

Chemical synapse

synaptic cleftpostsynapticpresynaptic neuron
Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.

Synaptic plasticity

plasticityneural plasticitychanges
Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.

Nervous system

neuralnervousneurogenic
Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.

Neuron

neuronsnerve cellsnerve cell
Trk receptors affect neuronal survival and differentiation through several signaling cascades.

Cellular differentiation

differentiationcell differentiationdifferentiate
Trk receptors affect neuronal survival and differentiation through several signaling cascades.

Signal transduction

signaling pathwayssignaling cascadesignal transduction pathways
Trk receptors affect neuronal survival and differentiation through several signaling cascades.

Ligand

ligandsligand exchangebidentate ligand
The common ligands of trk receptors are neurotrophins, a family of growth factors critical to the functioning of the nervous system.

Growth factor

growth factorstrophic factortrophic factors
The common ligands of trk receptors are neurotrophins, a family of growth factors critical to the functioning of the nervous system.

Molecular binding

bindingbindbinds
The binding of these molecules is highly specific.

Dissociation constant

K i binding affinityaffinity
Each type of neurotrophin has different binding affinity toward its corresponding Trk receptor.

Tropomyosin

t'''ropomyosin
The abbreviation trk (often pronounced 'track') stands for tropomyosin receptor kinase or tyrosine receptor kinase (and not "tyrosine kinase receptor" nor "tropomyosin-related kinase", as has been commonly mistaken).

Receptor (biochemistry)

receptorreceptorscellular receptors
The abbreviation trk (often pronounced 'track') stands for tropomyosin receptor kinase or tyrosine receptor kinase (and not "tyrosine kinase receptor" nor "tropomyosin-related kinase", as has been commonly mistaken).

Kinase

kinaseskinase domainprotein kinase C
The abbreviation trk (often pronounced 'track') stands for tropomyosin receptor kinase or tyrosine receptor kinase (and not "tyrosine kinase receptor" nor "tropomyosin-related kinase", as has been commonly mistaken).

Colorectal cancer

colon cancerbowel cancerintestinal cancer
Trk, initially identified in a colon carcinoma, is frequently (25%) activated in thyroid papillary carcinomas.

Thyroid cancer

thyroidcancerMalignant neoplasm of thyroid gland
Trk, initially identified in a colon carcinoma, is frequently (25%) activated in thyroid papillary carcinomas.

Mutation

mutationsgenetic mutationmutated
The oncogene was generated by a mutation in chromosome 1 that resulted in the fusion of the first seven exons of tropomyosin to the transmembrane and cytoplasmic domains of the then-unknown TrkA receptor.