Tropical sprue

spruesprue, tropical
Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal flattening of the villi and inflammation of the lining of the small intestine.wikipedia
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malabsorption syndromeintestinal malabsorptionmalabsorption of nutrients
Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal flattening of the villi and inflammation of the lining of the small intestine.
OGD to detect duodenal pathology and obtain D2 biopsy (for coeliac disease, tropical sprue, Whipple's disease, abetalipoproteinaemia etc.)

Small intestine

small bowelsmall intestinessmall
Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal flattening of the villi and inflammation of the lining of the small intestine.
Tropical sprue


steatorrhoeafatty stoolfatty feces
Steatorrhoea or fatty stool (often foul-smelling and whitish in colour)
Conditions producing intestinal malabsorption. These include celiac disease, bacterial overgrowth, tropical sprue, Giardiasis (a protozoan parasite infection), Zollinger-Ellison syndrome, short bowel syndrome, inflammatory bowel disease and abetalipoproteinemia.

Tom Douglas Spies

The use of folic acid and vitamin B 12 in the treatment of tropical sprue was promoted in the late 1940s by Dr. Tom Spies of the University of Alabama, while conducting his research in Cuba and Puerto Rico.
Later, he also made a large contribution to finding cure for tropical sprue.

Coeliac disease

celiac diseasecoeliacceliac
It differs significantly from coeliac sprue.
The villous atrophy seen on biopsy may also be due to unrelated causes, such as tropical sprue, giardiasis and radiation enteritis.

Small intestinal bacterial overgrowth

bacterial overgrowthsmall bowel bacterial overgrowth syndromesmall intestine bacterial overgrowth
Folic acid deficiency, effects of malabsorbed fat on intestinal motility, and persistent small intestinal bacterial overgrowth may combine to cause the disorder.
There is an overlap in findings between tropical sprue, post-infectious irritable bowel syndrome and small intestinal bacterial overgrowth in the pathophysiology of the three conditions and also SIBO can similarly sometimes be triggered by an acute gastrointestinal infection.

William Hillary (physician)

William Hillary
The disease was first described by William Hillary in 1759 in Barbados.
It contains the first description of tropical sprue.

Ramón M. Suárez Calderon

Dr. Ramón M. Suárez CalderonRamón M. Suárez
Dr. Ramón M. Suárez Calderón (1895–1981) was a scientist, cardiologist, educator and hematologíst whose investigations led him to identify the proper and effective treatment of a specific anemia known as tropical sprue.


allergic contact stomatitisgingivostomatitisinflammation of the mouth
Examples include tropical sprue.

Irritable bowel syndrome

IBSbowelirritable bowel
A link between small intestinal bacterial overgrowth and tropical sprue has been proposed to be involved in the cause of post-infectious IBS.

Pearl S. Buck

Pearl BuckPearls S. Buck Foundation
In 1921, Buck's mother died of a tropical disease, sprue, and shortly afterward her father moved in. In 1924, they left China for John Buck's year of sabbatical and returned to the United States for a short time, during which Pearl Buck earned her master's degree from Cornell University.

Stomach cancer

gastric cancerstomachgastric carcinoma
These can be symptoms of other problems such as a stomach virus, gastric ulcer, or tropical sprue.

Charles Kellaway

At the suggestion of Neil Hamilton Fairley – then resident at the Hall Institute whilst recuperating from tropical sprue – a significant research programme was instigated into Australian snake venoms.

Duodenal lymphocytosis

The list of possible causes is wide, including coeliac disease, environmental enteropathy (tropical sprue), autoimmune enteropathy, small intestinal bacterial overgrowth, NSAID damage, Helicobacter pylori, other infections and Crohn's disease.


Malabsorption of vitamin B 12 resulting from damage to the stomach, where intrinsic factor is secreted, or damage to the ileum, where intrinsic factor facilitates vitamin B 12 absorption. These conditions include tropical sprue and nontropical sprue (celiac disease).

Cornelius P. Rhoads

Cornelius Packard RhodesCornelius Rhoads
Castle's research interest was pernicious iron deficiency anemia, specifically as caused by the parasitic hookworm, which was endemic on the island at rates of 80%, and tropical sprue.


atrophic glossitisstrawberry tonguehemiglossitis
Sprue (celiac disease, or tropical sprue), secondary to nutritional deficiencies

Vitamin A deficiency

shortage of dietary vitamin AAvitamin A
In general, people should also seek medical advice before taking vitamin A supplements if they have any condition associated with fat malabsorption such as pancreatitis, cystic fibrosis, tropical sprue, and biliary obstruction.

Gastrointestinal disease

gastrointestinal disordersgastrointestinal disordergastrointestinal symptom
Chronic diseases of malabsorption may affect the small intestine, including the autoimmune coeliac disease, infective Tropical sprue, and congenital or surgical short bowel syndrome.

Philip Manson-Bahr

Sir Philip Edmund Clinton Manson-BahrSir Philip Henry Manson-Bahr
In 1912 he spent 14 months in Ceylon (now Sri Lanka) upon an invitation by Tea Planter's Association to investigate tropical sprue.

Debora Green

Basing their conclusions on the likelihood that his illness was related to the Peru trip, doctors narrowed down the possible causes for Farrar's gastrointestinal issues to a handful, though none fitted his symptoms perfectly: typhoid fever, tropical sprue, or gluten-sensitive enteropathy.

Eric Nave

R. E. (Eric) NaveTheodore Eric Nave
However, the pressure of work had begun to take its toll on Nave's health, and in early 1940 he was diagnosed as suffering from tropical sprue, and was sent back to Australia to recuperate.

William Bosworth Castle

William B. CastleWilliam CastleW. B. Castle
Anemia was widespread on the island because of the endemic parasite hookworm and tropical sprue, the latter a disease which scientists thought possibly related to diet.