Tropical sprue

spruesprue, tropical
Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal flattening of the villi and inflammation of the lining of the small intestine.wikipedia
98 Related Articles

Malabsorption

malabsorption syndromeintestinal malabsorptionmalabsorption of nutrients
Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal flattening of the villi and inflammation of the lining of the small intestine.
OGD to detect duodenal pathology and obtain D2 biopsy (for coeliac disease, tropical sprue, Whipple's disease, abetalipoproteinaemia etc.)

Small intestine

small bowelsmall intestinessmall
Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal flattening of the villi and inflammation of the lining of the small intestine.
Tropical sprue

Steatorrhea

steatorrhoeafatty stoolfatty feces
Steatorrhoea or fatty stool (often foul-smelling and whitish in colour)
Conditions producing intestinal malabsorption. These include celiac disease, bacterial overgrowth, tropical sprue, Giardiasis (a protozoan parasite infection), Zollinger-Ellison syndrome, short bowel syndrome, inflammatory bowel disease and abetalipoproteinemia.

Coeliac disease

celiac diseasecoeliacceliac
It differs significantly from coeliac sprue.
The villous atrophy seen on biopsy may also be due to unrelated causes, such as tropical sprue, giardiasis and radiation enteritis.

Small intestinal bacterial overgrowth

bacterial overgrowthsmall bowel bacterial overgrowth syndromesmall intestine bacterial overgrowth
Folic acid deficiency, effects of malabsorbed fat on intestinal motility, and persistent small intestinal bacterial overgrowth may combine to cause the disorder.
There is an overlap in findings between tropical sprue, post-infectious irritable bowel syndrome and small intestinal bacterial overgrowth in the pathophysiology of the three conditions and also SIBO can similarly sometimes be triggered by an acute gastrointestinal infection.

Tom Douglas Spies

The use of folic acid and vitamin B 12 in the treatment of tropical sprue was promoted in the late 1940s by Dr. Tom Spies of the University of Alabama, while conducting his research in Cuba and Puerto Rico.
Later, he also made a large contribution to finding cure for tropical sprue.

William Hillary (physician)

William Hillary
The disease was first described by William Hillary in 1759 in Barbados.
It contains the first description of tropical sprue.

Intestinal villus

villiintestinal villivillus
Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal flattening of the villi and inflammation of the lining of the small intestine.

Inflammation

inflammatoryinflammatory responseinflamed
Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal flattening of the villi and inflammation of the lining of the small intestine.

Fever

febrilepyrexiaague
The illness usually starts with an attack of acute diarrhoea, fever and malaise following which, after a variable period, the patient settles into the chronic phase of diarrhoea, steatorrhoea, weight loss, anorexia, malaise, and nutritional deficiencies.

Malaise

a general sense of feeling unwellfeeling tiredgeneral discomfort
The illness usually starts with an attack of acute diarrhoea, fever and malaise following which, after a variable period, the patient settles into the chronic phase of diarrhoea, steatorrhoea, weight loss, anorexia, malaise, and nutritional deficiencies.

Weight loss

weight-losslose weightlosing weight
The illness usually starts with an attack of acute diarrhoea, fever and malaise following which, after a variable period, the patient settles into the chronic phase of diarrhoea, steatorrhoea, weight loss, anorexia, malaise, and nutritional deficiencies. Weight loss and malnutrition

Anorexia (symptom)

anorexialoss of appetitedecreased appetite
The illness usually starts with an attack of acute diarrhoea, fever and malaise following which, after a variable period, the patient settles into the chronic phase of diarrhoea, steatorrhoea, weight loss, anorexia, malaise, and nutritional deficiencies.

Vitamin deficiency

vitamin deficienciesavitaminosishypovitaminosis
Left untreated, nutrient and vitamin deficiencies may develop in patients with tropical sprue.

Diarrhea

diarrhoeadiarrheal diseaseschronic diarrhea
Diarrhoea

Indigestion

dyspepsiafunctional dyspepsiadyspeptic
Indigestion

Malnutrition

malnourishednutritional deficienciesmalnourishment
Weight loss and malnutrition

Vitamin A

Avitamins ARAE
Vitamin A deficiency: hyperkeratosis or skin scales

Hyperkeratosis

hyperkeratoticFollicular hyperkeratosishyperkeratoses
Vitamin A deficiency: hyperkeratosis or skin scales

Vitamin B12

vitamin B 12 cobalaminB12
Vitamin B 12 and folic acid deficiencies: anaemia

Anemia

anaemiaanemicanaemic
Vitamin B 12 and folic acid deficiencies: anaemia

Vitamin D

Dcalciferol1,25 Dihydroxy vitamin D
Vitamin D and calcium deficiencies: spasm, bone pain, numbness, and tingling sensation