Tyrosine-protein kinase SYK

SykSyk inhibitorspleen tyrosine kinaseSYK (gene)Syk-ZAP-70
Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene.wikipedia
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ZAP70

ZAP-70zap-70 protein-tyrosine kinase
SYK, along with Zap-70, is a member of the Syk family of tyrosine kinases.
In systemic lupus erythematosus, the Zap-70 receptor pathway is missing and Syk takes its place.

SH2 domain

SH2ShcSrc homology 2
These non-receptor cytoplasmic tyrosine kinases share a characteristic dual SH2 domain separated by a linker domain.

Tyrosine kinase

tyrosine kinasesprotein-tyrosine kinaseprotein tyrosine kinase
SYK, along with Zap-70, is a member of the Syk family of tyrosine kinases.
SYK; TEC;

Entospletinib

Syk inhibitors are in clinical development, including cerdulatinib and entospletinib.
It is an inhibitor of spleen tyrosine kinase (Syk).

Fostamatinib

Tamatinib
The orally active SYK inhibitor fostamatinib (R788) in the treatment of rheumatoid arthritis.
The drug is administered orally as a disodium hexahydrate salt, and is a prodrug of the active compound tamatinib (R-406), which is an inhibitor of the enzyme spleen tyrosine kinase (Syk), hence it is an syk inhibitor.

Cerdulatinib

Syk inhibitors are in clinical development, including cerdulatinib and entospletinib.
It has lowest nM IC50 values against TYK2, JAK1, JAK2, JAK3, FMS, and SYK.

Chronic lymphocytic leukemia

B-cell chronic lymphocytic leukemiachronic lymphocytic leukaemiasmall lymphocytic lymphoma
Syk inhibition has been proposed as a therapy for both lymphoma and chronic lymphocytic leukemia.
Syk inhibitor fostamatinib is in trials.

LYN

Lyn (Src family kinase)p56lyn
LYN activation triggers a cascade of signaling events mediated by Lyn phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the receptor proteins, and subsequent recruitment and activation of other kinases including Syk, phosholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase.

FCGR2A

FcγRIIACD32AFc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2A has been shown to interact with PIK3R1 and Syk.

Lck

lymphocyte specific protein tyrosine kinase p56(lck)lymphocyte-specific protein tyrosine kinase

PTK2

focal adhesion kinaseFAKfocal adhesion kinase (FAK)

Enzyme

enzymologyenzymesenzymatic
Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene.

Gene

genesnumber of genesgene sequence
Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene.

B cell

B cellsB-cellB lymphocytes
Within B and T cells respectively, Syk and Zap-70 transmit signals from the B-Cell receptor and T-Cell receptor.

T cell

T cellsT-cellT-cells
Within B and T cells respectively, Syk and Zap-70 transmit signals from the B-Cell receptor and T-Cell receptor.

CD74

invariant chainCLIP
Syk plays a similar role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins.

Fc receptor

Fc receptorsFcγ receptorsFc
Syk plays a similar role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins.

Integrin

integrinsintegrin receptorintegrin alpha1
Syk plays a similar role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins.

ITK (gene)

ITKEMTITK1
Abnormal function of Syk has been implicated in several instances of hematopoeitic malignancies including translocations involving Itk and Tel.

ETV6

TEL
Abnormal function of Syk has been implicated in several instances of hematopoeitic malignancies including translocations involving Itk and Tel.