Tyrosine kinase 2

TYK2TYK
Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene.wikipedia
64 Related Articles

Janus kinase 3

JAK3
Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3).
Other members of the Janus family include JAK1, JAK2 and TYK2.

Janus kinase

JAKJAK kinasesJanus Kinases
Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). This gene encodes a member of the tyrosine kinase and, to be more specific, the Janus kinases (JAKs) protein families.

Interleukin 12

IL-12interleukin-12IL12
It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals.
The trait was mapped to mutations in the STAT1 gene, which were associated with lower production of interferon-γ, IL-17, and IL-22 in response to IL-12 or IL-23 receptor associated Jak2 and Tyk2 activity.

Tyrosine kinase

tyrosine kinasesprotein-tyrosine kinaseprotein tyrosine kinase
This gene encodes a member of the tyrosine kinase and, to be more specific, the Janus kinases (JAKs) protein families.
TYK2; TYRO3; YES1; ZAP70

Interleukin 23

IL-23interleukin-23IL23
However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals.
IL-23 heterodimer binds the receptor complex - p19 subunit binds IL-23R while p40 subunit binds IL-12RB1 which leads to recruitment of Janus kinase 2 and Tyrosine kinase 2 kinases.

Hyperimmunoglobulin E syndrome

Job's syndromeHyper-IgE syndromeJob syndrome
A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Genetic testing is available for STAT3 (Job's Syndrome), DOCK8 (DOCK8 Immunodeficiency or DIDS), PGM3 (PGM3 deficiency), SPINK5 (Netherton Syndrome - NTS), and TYK2 genetic defects.

FYN

Fyn tyrosine kinase
Tyrosine kinase 2 has been shown to interact with FYN, PTPN6, IFNAR1, Ku80 and GNB2L1.

PTPN6

SHP-1SHP1HP-1
Tyrosine kinase 2 has been shown to interact with FYN, PTPN6, IFNAR1, Ku80 and GNB2L1.

IFNAR1

IFNγR1
Tyrosine kinase 2 has been shown to interact with FYN, PTPN6, IFNAR1, Ku80 and GNB2L1.

Ku80

XRCC580Ku86
Tyrosine kinase 2 has been shown to interact with FYN, PTPN6, IFNAR1, Ku80 and GNB2L1.

Receptor for activated C kinase 1

GNB2L1RACK1RACK protein
Tyrosine kinase 2 has been shown to interact with FYN, PTPN6, IFNAR1, Ku80 and GNB2L1.

Enzyme

enzymologyenzymesenzymatic
Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene.

Gene

genesnumber of genesgene sequence
Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene.

Janus kinase 1

JAK1JAKJAK 1
Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3).

Janus kinase 2

JAK22JAK
Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3).

Interferon

interferonsIFNIFN-γ
It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling.

Interleukin 6

IL-6interleukin-6IL6
It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals.

Interleukin 10

IL-10interleukin-10IL10
It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals.

Cytokine receptor

cytokinecytokine receptorsneurocytokine receptor
This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. The connection between Jaks and cytokine signaling was first revealed when a screen for genes involved in interferon type I (IFN-1) signaling identified Tyk2 as an essential element, which is activated by an array of cytokine receptors.

Interferon type I

interferon alphatype I interferoninterferon beta
However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. The connection between Jaks and cytokine signaling was first revealed when a screen for genes involved in interferon type I (IFN-1) signaling identified Tyk2 as an essential element, which is activated by an array of cytokine receptors.

Glycoprotein 130

gp130IL6STCD130
Since, IL-6 signals through the gp-130 receptor-chain that is common to a large family of cytokines, including IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), ciliary neurotrophic factor, cardiotrophin 1, cardiotrophin-like cytokine, and LIF, Tyk2 might also affect signaling through these cytokines.

Interleukin 11

IL-11interleukin-11IL11
Since, IL-6 signals through the gp-130 receptor-chain that is common to a large family of cytokines, including IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), ciliary neurotrophic factor, cardiotrophin 1, cardiotrophin-like cytokine, and LIF, Tyk2 might also affect signaling through these cytokines.

Interleukin 27

IL-27IL27interleukin-27
Since, IL-6 signals through the gp-130 receptor-chain that is common to a large family of cytokines, including IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), ciliary neurotrophic factor, cardiotrophin 1, cardiotrophin-like cytokine, and LIF, Tyk2 might also affect signaling through these cytokines.

Interleukin 31

IL-31IL31interleukin-31
Since, IL-6 signals through the gp-130 receptor-chain that is common to a large family of cytokines, including IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), ciliary neurotrophic factor, cardiotrophin 1, cardiotrophin-like cytokine, and LIF, Tyk2 might also affect signaling through these cytokines.

Oncostatin M

OSMoncostatin M (OSM)OSM-R
Since, IL-6 signals through the gp-130 receptor-chain that is common to a large family of cytokines, including IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), ciliary neurotrophic factor, cardiotrophin 1, cardiotrophin-like cytokine, and LIF, Tyk2 might also affect signaling through these cytokines.