A report on WHO Model List of Essential Medicines and Valproate

2017 marked the 40th anniversary of the WHO Model List of Essential Medicines.
500mg tablets of Depakote extended-release
A skeletal model of the chemical structure of aspirin
Some metabolites of valproic acid. Glucuronidation and β-oxidation are the main metabolic pathways; ω-oxidation metabolites are considered hepatotoxic. Details see text.
A skeletal model of the chemical structure of albendazole
Pure crystals of ethambutol
Two capsules of atazanavir
Bag containing one unit of fresh frozen plasma
A vial of oral cholera vaccine

It is on the World Health Organization's List of Essential Medicines and is available as a generic medication.

- Valproate

Valproic acid (sodium valproate)

- WHO Model List of Essential Medicines
2017 marked the 40th anniversary of the WHO Model List of Essential Medicines.

5 related topics with Alpha

Overall

Carbamazepine

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Anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.

Anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.

Tegretol 200-mg CR (made in NZ)
Metabolism. Top: carbamazepine • middle: carbamazepine-10,11-epoxide, the active metabolite • bottom: carbamazepine-10,11-diol, an inactive metabolite, which is then glucuronidized

Carbamazepine appears to work as well as phenytoin and valproate for focal and generalized seizures.

It is on the World Health Organization's List of Essential Medicines.

Lamotrigine, 150 mg tablet.

Lamotrigine

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Medication used to treat epilepsy and stabilize mood in bipolar disorder.

Medication used to treat epilepsy and stabilize mood in bipolar disorder.

Lamotrigine, 150 mg tablet.
Lamictal 200 mg tablets

It is on the World Health Organization's List of Essential Medicines.

Combination with valproate is common, but this increases the risk of lamotrigine-induced rash, and necessitates reduced dosing due to the interaction of these drugs.

Ethosuximide

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Medication used to treat absence seizures.

Medication used to treat absence seizures.

It may be used by itself or with other antiseizure medications such as valproic acid.

It is on the World Health Organization's List of Essential Medicines.

Aspirin

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Medication used to reduce pain, fever, or inflammation.

Medication used to reduce pain, fever, or inflammation.

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1923 advertisement
Old package. "Export from Germany is prohibited"

It is on the World Health Organization's List of Essential Medicines.

Aspirin is known to displace a number of drugs from protein-binding sites in the blood, including the antidiabetic drugs tolbutamide and chlorpropamide, warfarin, methotrexate, phenytoin, probenecid, valproic acid (as well as interfering with beta oxidation, an important part of valproate metabolism), and other NSAIDs.

Folate

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One of the B vitamins.

One of the B vitamins.

Chemical structure of the folate family
Biotransformation of folic acid into folinic acids where R = para-aminobenzoate-glutamate.
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In the United States and many other countries, wheat flour is fortified with folic acid; some countries also fortify maize flour and rice.

It is on the World Health Organization's List of Essential Medicines.

Valproic acid, one of the most commonly prescribed epilepsy treatment drugs, also used to treat certain psychological conditions such as bipolar disorder, is a known inhibitor of folic acid, and as such, has been shown to cause birth defects, including neural tube defects, plus increased risk for children having cognitive impairment and autism.