2017 marked the 40th anniversary of the WHO Model List of Essential Medicines.
A skeletal model of the chemical structure of aspirin
Vitamin K1-warfarin interaction effect. When warfarin levels are high, people have more risk of bleeding. Conversely, lower levels of warfarin lead to increased risk of blood clots. There is a narrow range where the benefits of warfarin are greater than the risks, its therapeutic window. Certain drugs, herbal medicines, and foods can interact with warfarin, increasing or decreasing a previously stable warfarin level.
A skeletal model of the chemical structure of albendazole
Acyclic tautomer (left) and cyclic hemiketal tautomer (right)
Pure crystals of ethambutol
3 mg (blue), 5 mg (pink) and 1 mg (brown) warfarin tablets (UK colours)
Two capsules of atazanavir
Warning label on a tube of rat poison laid on a dike of the Scheldt river in Steendorp, Belgium. The tube contains bromadiolone, a second-generation ("super-warfarin") anticoagulant.
Bag containing one unit of fresh frozen plasma
A vial of oral cholera vaccine

It is on the World Health Organization's List of Essential Medicines.

- Warfarin

Warfarin

- WHO Model List of Essential Medicines
2017 marked the 40th anniversary of the WHO Model List of Essential Medicines.

7 related topics with Alpha

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Phytomenadione

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Vitamin found in food and used as a dietary supplement.

Vitamin found in food and used as a dietary supplement.

The biosynthesis of vitamin K1 via the transformation of chorismate occurs in nine steps.

It is on the World Health Organization's List of Essential Medicines.

This includes warfarin overdose, vitamin K deficiency, and obstructive jaundice.

Aspirin

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Medication used to reduce pain, fever, or inflammation.

Medication used to reduce pain, fever, or inflammation.

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1923 advertisement
Old package. "Export from Germany is prohibited"

It is on the World Health Organization's List of Essential Medicines.

Even if none of these conditions is present, the risk of stomach bleeding is still increased when aspirin is taken with alcohol or warfarin.

Dabigatran

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Anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation.

Anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation.

It is used as an alternative to warfarin and does not require monitoring by blood tests.

It is on the World Health Organization's List of Essential Medicines.

Platelet factor 4 can cause heparin-induced thrombocytopenia.

Prothrombin complex concentrate

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Medication made up of blood clotting factors II, IX, and X.

Medication made up of blood clotting factors II, IX, and X.

Platelet factor 4 can cause heparin-induced thrombocytopenia.

It may also be used for reversal of warfarin therapy.

It is on the World Health Organization's List of Essential Medicines.

Metronidazole

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Antibiotic and antiprotozoal medication.

Antibiotic and antiprotozoal medication.

A tube of metronidazole
Hydroxymetronidazole, the main metabolite

It is on the World Health Organization's List of Essential Medicines.

Examples of such medications are lomitapide, warfarin, etc.

A vial of heparin sodium for injection

Heparin

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Medication and naturally occurring glycosaminoglycan.

Medication and naturally occurring glycosaminoglycan.

A vial of heparin sodium for injection
Heparin vial for subcutaneous injection
Ball-and-stick model of heparin
UA(2S)-GlcNS(6S)
IdoA(2S)-aMan: The anhydromannose can be reduced to an anhydromannitol
<center>GlcA-GlcNAc</center>
<center>GlcA-GlcNS</center>
<center>IdoA-GlcNS</center>
<center>IdoA(2S)-GlcNS</center>
<center>IdoA-GlcNS(6S)</center>
<center>IdoA(2S)-GlcNS(6S)</center>

It is on the World Health Organization's List of Essential Medicines.

If long-term anticoagulation is required, heparin is often used only to commence anticoagulation therapy until an oral anticoagulant e.g. warfarin takes effect.

A bag containing one unit of fresh frozen plasma

Fresh frozen plasma

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Blood product made from the liquid portion of whole blood.

Blood product made from the liquid portion of whole blood.

A bag containing one unit of fresh frozen plasma
Albumin

It is on the World Health Organization's List of Essential Medicines.

Reversal of warfarin effect: Warfarin.svgnts who are anticoagulated with warfarin are deficient in the functional vitamin K dependent coagulation factors II, VII, IX, and X, as well as proteins C and S. These functional deficiencies can be reversed by the administration of vitamin K. For anticoagulated patients who are actively bleeding or who require emergency surgery, prothrombin complex concentrate (ideally, four factor PCCs) should be used if available. FFP/PF24/thawed plasma should only be used if more effective alternative treatments are not available. The ASA task force recommends starting with 5–8 mL/kg of FFP for warfarin reversal and rechecking laboratory values.