White pulp

splenic lymphoid nodulesMalpighian bodies of the spleenMalpighian corpuscleMalpighian corpusclesSplenic white pulpwhite-pulp
White pulp is a histological designation for regions of the spleen (named because it appears whiter than the surrounding red pulp on gross section), that encompasses approximately 25% of splenic tissue.wikipedia
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Spleen

splenicsplenetichilum
White pulp is a histological designation for regions of the spleen (named because it appears whiter than the surrounding red pulp on gross section), that encompasses approximately 25% of splenic tissue.
The spleen synthesizes antibodies in its white pulp and removes antibody-coated bacteria and antibody-coated blood cells by way of blood and lymph node circulation.

Periarteriolar lymphoid sheaths

Periarteriolar lymphoid sheaths (or periarterial lymphatic sheaths, or PALS) are a portion of the white pulp of the spleen.

Marginal zone

zone
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen.

Red pulp

Red Pulp Macrophagesplenic pulpSplenic red pulp
The spleen is made of red pulp and white pulp, separated by the marginal zone; 76-79% of a normal spleen is red pulp.

Lymphatic system

lymphoidlymphoid tissuelymphatic
These macrophages are not unique to the spleen but instead make up an integral part of the lymphoid parts of all secondary lymphoid organs.

Trabecular arteries

trabecular artery
When these arteries then reach the white pulp, and become covered with periarteriolar lymphoid sheaths, the name changes again to central arteries (or central arterioles).

Antigen-presenting cell

antigen-presenting cellsantigen presenting cellantigen presenting cells

T cell

T cellsT-cellT-cells
The T cell zone (periarteriolar sheath) and B cell follicles contain discrete macrophage populations; however, not much is known about these macrophage populations in terms of their origin and lifespan.

B cell

B cellsB-cellB lymphocytes
The T cell zone (periarteriolar sheath) and B cell follicles contain discrete macrophage populations; however, not much is known about these macrophage populations in terms of their origin and lifespan.

Macrophage

macrophagesM2 macrophagesTissue macrophages
The T cell zone (periarteriolar sheath) and B cell follicles contain discrete macrophage populations; however, not much is known about these macrophage populations in terms of their origin and lifespan.

Germinal center

germinal centersgerminal centregerminal centres
In the B cell follicles, the macrophages are important in clearing the apoptotic B cells that occur during the germinal centre reaction in the process of somatic hypermutation and isotype switching.

Somatic hypermutation

hypermutationsomatic hypermutation, immunoglobulinadaptation
In the B cell follicles, the macrophages are important in clearing the apoptotic B cells that occur during the germinal centre reaction in the process of somatic hypermutation and isotype switching.

Immunoglobulin class switching

class switchingisotype switchingClass switch recombination
In the B cell follicles, the macrophages are important in clearing the apoptotic B cells that occur during the germinal centre reaction in the process of somatic hypermutation and isotype switching.

Apoptosis

apoptoticprogrammed cell deathcell death
B cells that cannot form their appropriate receptors will die of apoptosis and are subsequently cleared by the macrophages in the germinal centre.

Tingible body macrophage

During intensive germinal centre reactions, this process is obvious due to the presence of the large macrophages in the germinal centre, known as tingible body macrophages.

Phosphatidylserine

phosphatidyl serine(3-sn-phosphatidyl)-L-serinephosphatidylserin
(They're named this because their 'tingible bodies' represent condensed apoptotic nuclei.) In order for the apoptotic cells to be taken up by macrophages, it is important that phosphatidylserine is expressed on the outer surface of the apoptotic cells, which is recognized by multiple receptors.

Monocyte

monocytesmonocyticmononuclear
It is possible that these macrophages are descendants of patrolling monocytes that entered the white pulp from the blood.

Antigen presentation

antigen recognitionpresentedpresent
Due to them being positioned alongside T cells, it is suggested that these macrophages have a role in antigen presentation or the removal of dying lymphocytes.

Lymphocyte

lymphocyteslymphocyticlymphoid cells
Due to them being positioned alongside T cells, it is suggested that these macrophages have a role in antigen presentation or the removal of dying lymphocytes.